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Biomedical subjects

H W Fox

Publications and source records attributed to H W Fox.

8 recordsLinked to original sources
PubMed1985

Three decades of lung cancer in Christchurch.

The hospital admission rate and management of bronchogenic carcinoma over a period of three decades has been studied by reviewing admissions to the acute general hospitals in Christchurch, using five year samples. Although there was an improvement in the management of the disease between the first and second decades, this plateaued between the second and third. In the first five year period, (1952-6), 97 (47%) out of 208 patients were dead within a month of diagnosis and six patients lived for more than three years. In 1962-66 (21%) out of 328 patients were dead within a month of diagnosis and 25 patients lived longer than three years. In the last five year period (1972-6) 75 patients (16.8%) out of 707 were dead within one month of diagnosis and 46 survived for more than three years. Twenty-six patients remained alive and well seven to eleven years after diagnosis, a long term survival rate of 3.6%.

Adult↗
PubMed1985

Inhibition of aflatoxin B1-hepatocarcinogenesis in rats by beta-naphthoflavone.

Effects of beta-naphthoflavone (beta NF) on the activity of hepatic microsomal aflatoxin B1 (AFB1)-4-hydroxylase - the cytochrome P-450-dependent enzyme system which catalyzes the metabolism of AFB1 to AFM1 - and on AFB1-induced in vivo hepatocarcinogenesis were investigated in weanling male Fischer rats. A single i.p. injection of beta NF in doses of 20 mg/kg and 150 mg/kg induced AFB1-4-hydroxylase 3- and 4-fold, respectively, 48 h post injection. Feeding of diet containing 0.01% beta NF for a period of 9-weeks induced AFB1-4-hydroxylase approximately 2-fold. AFB1, given by intubation in a dose of 25 micrograms five times/week for 8 weeks, produced 42 weeks later a 100% incidence of liver lesions (neoplastic foci, nodules or tumors), but feeding beta-NF in diet at a concentration of 0.015% for one week prior to and during the 8 weeks of AFB1 treatment inhibited AFB1 hepatocarcinogenesis by approximately 75%. These results are in accord with the suggestion that AFB1-4-hydroxylase induction may be associated with the inhibition of AFB1 carcinogenesis, possibly occurring as a consequence of accelerated detoxification of AFB1 via its conversion to AFM1.

Aflatoxin B1↗
PubMed1981

Bone marrow transplantation for acute leukaemia and severe marrow aplasia: an analysis of five patients.

Five patients, three with severe aplasia and two with acute leukaemia have been treated by bone marrow transplantation (BMT). Four are alive and well with excellent graft function. One showed engraftment but died of acute graft-versus-host disease (GVH); this patient and his donor were hepatitis B antigen positive. Three show evidence of mild chronic GVH, two patients requiring control by immunosuppressive therapy. Bone marrow transplantation (BMT) has now become an established method of treatment in severe aplasia and in acute leukaemia and our results serve to emphasise this. The clinical and organisational problems associated with BMT are discussed.

Adolescent↗
PubMed1980

Bone marrow transplantation for severe aplastic anaemia.

An eight-year-old girl with severe acquired aplastic anaemia received a bone marrow transplant from her 11-year-old brother. The bone marrow graft is firmly established, but the patient has mild chronic graft versus host disease affecting liver and skin. The indications for bone marrow transplantation in aplastic anaemia are discussed.

Anemia, Aplastic↗
PubMed1975

Cocarcinogenic activity of peroxy compounds.

Peracetic acid was a potent tumor promoter and a weak complete carcinogen on the skin of female ICR Swiss mice. "Decomposed peracetic acid" was inactive as a tumor promoter, as were 3% [hydrogen peroxide and 5%] urea peroxide; 1% perbenzoic acid and m-chloroperbenzoic acid were active tumor prototers.

9,10-Dimethyl-1,2-benzanthracene↗