PubMed HealthSearch

Biomedical subjects

H W Glindmeyer

Publications and source records attributed to H W Glindmeyer.

2 recordsLinked to original sources

A comparison of the Jones and Stead-Wells spirometers.

A comparison was made between the noncounterweighted Jones and Stead-Wells spirometers, and "conversion factors" were determined for the forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC). A cross-sectional study produced a high correlation between the instruments for these two measurements, yielding quadratic and linear regression equations ("conversion factors") for FEV1 and FVC, respectively. Standard deviations of measurements were similar for both spirometers. Results from a longitudinal study agreed with the "conversion factors" predicted from the cross-sectional study; however, significant day-to-day variability was observed by both spirometers. Neither spirometer met all of the technical recommendations proposed by the Committees on Environmental Health and Respiratory Physiology of the American College of Chest Physicians; however, the Stead-Wells water-sealed spirometer complied more often than the Jones waterless spirometer (Pulmonor). In addition, the open-circuit procedure used for the Jones spirometer required more corrdination in the subject than did the closed-circuit procedure employed in this study for the Stead-Wells spirometer; however, with application of the "conversion factors," both instruments, yield comparable data and prove adequate for spirometric studies.

Forced Expiratory Flow Rates

Longitudinal study of workers employed in the manufacture of toluene-diisocyanate.

Workers at a toluene-diisocyanate manufacturing plant were studied longitudinally to determine the effects of the chemical on their health. Studies included health questionnaire, pulmonary function, environmental monitoring, and immunologic testing. Workers reporting increased lower respiratory symptoms were from the nonsmoker group. Environmental monitoring showed frequent excursions of toluene-diisocyanate concentrations above the threshold limiting value. There was poor correlation between area and personal exposure levels. No exposure-related decline of pulmonary function was demonstrable. Immunologic studies showed development of a positive skin test to a toluene-diisocyanate-human serum albumin conjugate by some persons and an increasing incidence of toluene-diisocyanate-specific IgE antibodies as measured by a radioallergosorbent test. Toluene-diisocyanate did not induce histamine release from leukocytes in vitro but did diminish the in vitro stimulation of cyclic adenosine monophosphate by isoproterenol. Most of the clinically sensitive persons demonstrated adverse bronchial response when challenged by inhalation of toluene-diisocyanate. This response was dose dependent in some persons. When challenged with Mecholyl, clinically sensitive persons showed greater reactivity of airways than nonsensitive persons.

Antibodies