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Biomedical subjects

H W Grünwald

Publications and source records attributed to H W Grünwald.

At least 19 recordsLinked to original sources
PubMed1999

Low-grade lymphomas.

Explore the source record for details and available documents.

Antibodies, Monoclonal↗
PubMed1991

Use of vincristine in refractory thrombotic thrombocytopenic purpura.

We describe 3 patients with thrombotic thrombocytopenic purpura (TTP) treated with vincristine. In 2 of them, multimodality treatment with plasmapheresis, acetylsalicylic acid, dipyridamole, corticosteroids, and plasma infusions did not achieve lasting remission, subsequent to which the administration of vincristine was followed by prompt and durable remission. In the third patient, 1 mg of intravenous vincristine as initial therapy in conjunction with multimodality treatment resulted in the prompt resolution of the disease. Our experience suggests that vincristine is effective in the treatment of TTP and can be used as initial treatment in combination with other modalities.

Adolescent↗
PubMed1984

Association of T cell acute lymphoblastic leukemia and histiocytic medullary reticulosis.

Seventeen reported cases of acute lymphoblastic leukemia that terminated in a clinical picture of histiocytic medullary reticulosis were reviewed. Using the presence of T cell markers, mediastinal mass, or very high initial white blood cell count as suggestive of T cell acute lymphoblastic leukemia, nine of 13 evaluable cases fulfilled such criteria. This review raises the possibility that the histiocytic medullary reticulosis appearing in the course of T cell acute lymphoblastic leukemia is the result of lymphokine production by the leukemic cells.

Adolescent↗
PubMed1984

Simultaneous occurrence of multiple myeloma and acute myeloblastic leukemia: fact or myth?

A careful search of the literature disclosed 22 cases of the simultaneous occurrence of multiple myeloma and acute leukemia. An additional eight cases of macroglobulinemia and acute leukemia have also been described. Critical review of these reports, however, suggests that the concomitant occurrence of myeloma or Waldenström's macroglobulinemia and acute myeloblastic leukemia is quite uncommon and probably represents a coincidental or chance association.

Bone Marrow↗
PubMed1983

Second neoplasms in acute lymphoblastic leukemia.

The authors reviewed 61 reported cases of second neoplasms in acute lymphoblastic leukemia (ALL), including 17 patients with ALL followed by another type of acute leukemia, 12 patients with ALL followed by chronic myelocytic leukemia, 19 patients with ALL followed by lymphoma, and 13 patients with ALL followed by other solid tumors. From a review of the literature, it is believed that there is no firm evidence yet that patients with ALL, intensively treated with chemotherapy and/or radiotherapy, are at increased risk of developing therapy-related second neoplasms. Because the number of cases reported is small, there is even insufficient data to firmly suggest that acute myeloblastic leukemia, following intensive therapy for ALL, occurs in a higher-than-expected frequency.

Acute Disease↗
PubMed1982

Acute myeloid leukemia following treatment of Hodgkin's disease: a review.

Risk factors were analyzed and searched for possible predictive parameters for the development of acute myeloid leukemia in 216 reported patients previously treated for Hodgkin's disease. The distribution of histologic subtypes and the stage at diagnosis were similar to that of all patients with Hodgkin's disease. Seventy-five percent of the 216 patients in whom acute myeloid leukemia developed had received both radiotherapy and chemotherapy, 15% chemotherapy only, and 10% radiotherapy only. Of those receiving radiotherapy, 66% were given multiple courses or total nodal irradiation. Of the patients receiving chemotherapy, 77% had received more than eight months of single or combination drug therapy; only 4% had not been exposed to alkylating agents. When acute leukemia developed, 78% of the patients showed no clinical or pathologic evidence of residual Hodgkin's disease. A period of pancytopenia preceded the onset of overt leukemia in at least one-third of the patients. Complete or partial remission of the acute leukemia was achieved in 25% of the patients treated with antileukemic chemotherapy. On the basis of these findings, it is deemed advisable to reexamine the intensity of treatment presently being administered to achieve cure of Hodgkin's disease. Unnecessary or unproved programs of combined radiation therapy and chemotherapy should be avoided. An optimal balance between the risks and benefits of treatment needs to be applied.

Adolescent↗