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Biomedical subjects

H W Hense

Publications and source records attributed to H W Hense.

At least 19 recordsLinked to original sources
PubMed2006

Macular pigment optical density measurement in autofluorescence imaging: comparison of one- and two-wavelength methods.

BACKGROUND: Measurement of macular pigment (MP) can be performed by analysis of autofluorescence (AF) images. These can be obtained by standard 488-nm argon-imaging alone (one wavelength, 1-Lambda) or with additional digital subtraction of a second image at 514 nm (two wavelengths, 2-Lambda). The analyses are easy to perform, and we present a comparison of both methods and investigate their reliability and repeatability. METHODS: Inter-individual variability of MP optical density (MPOD) measurements was assessed in single eyes of 120 subjects with a modified Heidelberg retina angiograph (HRA). MPOD values obtained with one (488 nm) Lambda (MPOD(1Lambda)) were compared with those obtained with two (488 nm and 514 nm) Lambda (MPOD(2Lambda)). To test the repeatability of the two methods, 20 subjects were subjected to five repeated measurements. RESULTS: Among 120 individuals, mean MPOD(1Lambda) at 0.5 degrees eccentricity was 0.59 (range 0.06-1.32), mean MPOD(2Lambda) was 0.5 (range 0.01-1.21). Apart from this systematic difference, 1-Lambda and 2-Lambda measurements at 0.5 degrees agreed well across the range of MPOD values (beta=0.964, around the fovea, a systematic difference (0.11) was accompanied by declining agreement at higher MPOD values (beta=0.669, 95% CI 0.519-0.844; R=0.48). Among 20 subjects with five repeated measurements, the reliability ratio was 0.97 for 1-Lambda and 0.94 for 2-Lambda at 0.5 degrees and 0.93 and 0.94, respectively, at a distance of 2 degrees. CONCLUSIONS: Both methods showed a high repeatability with little influence of measurement error. They agree well at the fovea centre in terms of ranking individuals according to their MPOD, but provide increasingly deviating results at a distance of 2 degrees around the fovea, probably because the 1-Lambda method, in contrast to the 2-Lambda method, cannot compensate for disruptive influences and for heterogeneous distributions of the lipofuscin fluorophores. The 1-Lambda method can be performed by standard HRA and could therefore be used for screening in multicentre studies, but only approaches the actual amounts of MP. The 2-Lambda method remains the more precise method for MPOD measurement in autofluorescence imaging.

Adult↗
PubMed2005

[Association between classic cardiovascular risk factors and age-related maculopathy (ARM). Results of the baseline examination of the Münster Aging and Retina Study (MARS)].

BACKGROUND: Epidemiological studies have reported inconsistent associations between cardiovascular risk factors and the occurrence of age-related maculopathy (ARM). METHODS: In the baseline examination of the Muenster Aging and Retina Study (MARS), we assessed this potential relationship in 1060 subjects who underwent clinical and ophthalmologic examinations. The ARM status was graded according to international standardized classifications. RESULTS: There were 974 eye pairs available for analysis. Smoking, hypertension, hypercholesterolemia, and a history of myocardial infarction or stroke were found significantly more often in patients with ARM. There were no statistically significant multivariate associations between overweight, diabetes, or a history of myocardial infarction or stroke. CONCLUSIONS: Our results confirm previous epidemiological studies pointing to a potential role of atherosclerotic processes in the development of ARM.

Aged↗
PubMed2005

BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy.

BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BNP increased in subjects with diastolic dysfunction (mean 20.3+/-4.7 pg/ml vs. control 9.6+/-0.5 pg/ml, p<0.001), but to a lesser extent than in subjects with LV hypertrophy (LVH, mean 37.3+/-49.1 pg/ml, p<0.001 vs. control) or LVSD (mean 76.2+/-23.2 pg/ml, p<0.001 vs. control). Individuals with sole diastolic abnormality displayed BNP concentrations at the control level (mean 9.7+/-1.7 pg/ml). In univariate analysis, age, BMI, systolic blood pressure, left atrial size, LV mass index, diastolic dysfunction and EF displayed a significant correlation with BNP (p<0.001). However, LV mass index displaced diastolic dysfunction as a significant predictor of BNP in multivariate analysis. Upon ROC analysis, sensitivity and specificity for the detection of diastolic dysfunction by BNP were only 61% and 55%, respectively. Nevertheless, a normal BNP test virtually excluded the presence of diastolic dysfunction and concomitant LVH (NPV 99.9%). Increased BNP concentrations in subjects with diastolic dysfunction are strongly related to LVH. Population-wide screening for diastolic dysfunction with BNP cannot be recommended although a normal BNP test usually excludes diastolic dysfunction and LV hypertrophy.

Adult↗
PubMed2005

[Visual function and quality of life in patients with age-related maculopathy: results of the Münster Age and Retina Study (MARS)].

BACKGROUND: The aim of this study was to examine the association between increasing severity of age-related maculopathy (ARM) stages, visual function and quality of life. METHODS: Using the 25-item version of the National Eye Institute Visual Function Questionnaire (NEI VFQ) in the Münster age and retina study (MARS), 974 patients (normal fundus: n = 208; early ARM: n = 466; late ARM: n = 300) with bilateral gradable fundus photographs were asked about their visual function and quality of life. The NEI VFQ scales with regard to general health, general vision, near vision, distance vision and peripheral vision were assessed. According to the ARM stages, age- and gender-adjusted mean scores were calculated and tested for statistically significant differences. RESULTS: The perception of general health, general vision, near vision, distance vision and peripheral vision was getting worse with increasing severity of ARM stages. Comparing the maculopathy groups, significant differences in age- and gender-adjusted mean scores were found between patients with late ARM and healthy subjects and patients with late and early ARM. Furthermore, we observed for the dimension general vision a significant difference of the mean score between early ARM and healthy control group [mean score; early ARM: 68.7 (0.7) vs. control group: 72.2 (1.1); p = 0.005]. CONCLUSIONS: The results of the NEI VFQ reflect the clinical expectation of an inverse relation between increasing severity of ARM stages and visual function and quality of life.

Age Factors↗
PubMed2004

[Münster age- and retina study (MARS). Association between risk factors for arteriosclerosis and age-related macular degeneration].

BACKGROUND: The association between arteriosclerosis and age-related macular degeneration (AMD) has only been examined in a few studies and the data is still very inconsistent. METHODS: A cross sectional study was initiated with 730 patients from the Münster age and retina study (MARS) which examines patients in the age range 60 to 80 years old who were referred by ophthalmologists from the Muenster area. Patients with narrow angle glaucoma were excluded. All patients underwent a standardized ophthalmoscopic examination und were classified into four groups: group 1 without AMD ( n=190), group 2 with unilateral or bilateral early forms of AMD ( n=340), group 3 with unilateral late forms of AMD ( n=139) and group 4 with bilateral late forms of AMD ( n=50). By means of these groups it was tested if there was a significant difference between the different risk factors for arteriosclerosis. RESULTS: The mean age was 72 years and 58% were women and the sex distribution within the different groups did not differ significantly (all trend tests with p>0.1). General risk factors for arteriosclerosis such as diabetes, body-mass-index and hypertension did not differ significantly (all trend tests with p>0.1). The number of smokers increased significantly with the severity of AMD ( p=0.02). Furthermore, various lipids were examined, adjusted for age and sex and showed significant decrease of HDL ( p=0.087) and significant increases of the HDL/LDL quotient ( p=0.0007) and the non-sober triglyceride values ( p=0.0058) correlated with the severity of AMD. CONCLUSIONS: There was a highly significant, direct association of indicators of dyslipidemia such as increasing HDL/LDL quotient and decreasing HDL with the severity of AMD. These results were underlined by increased triglyceride levels even if they were taken non-sober. The results must be interpreted with caution due to the explorative character of the evaluation.

Age Distribution↗
PubMed2003

Prevalence of left ventricular diastolic dysfunction in the community. Results from a Doppler echocardiographic-based survey of a population sample.

AIMS: The prevalence of left ventricular diastolic abnormalities in the general population is largely unclear. Thus, the aim of this study was, firstly, to identify abnormal diastolic function by echocardiography in an age-stratified population-based European sample (MONICA Augsburg, n=1274, 25 to 75 years, mean 51+/-14) and, secondly, to analyse clinical and anthropometric parameters associated with diastolic abnormalities. METHODS AND RESULTS: The overall prevalence of diastolic abnormalities, as defined by the European Study Group on Diastolic Heart Failure (i.e. age dependent isovolumic relaxation time (92-105 ms) and early (E-wave) and late (A-wave) left ventricular filling (E/A-ratio, 1-0.5)) was 11.1%. When only subjects treated with diuretics or with left atrial enlargement were considered (suggesting diastolic dysfunction) the prevalence was 3.1%. The prevalence of diastolic abnormalities varied according to age: from 2.8% in individuals aged 25-35 years to 15.8% among those older than 65 years (P<0.01). Significantly higher rates of diastolic abnormalities were observed in men as compared to women (13.8% vs 8.6%, P<0.01). Independent predictors of diastolic abnormalities were arterial hypertension, evidence of left ventricular (LV) hypertrophy, and coronary artery disease. Interestingly, in the absence of these predisposing conditions, diastolic abnormalities (4.3%) or diastolic dysfunction (1.1%) were rare, even in subjects older than 50 years of age (4.6%) and (1.2%), respectively. In addition to these factors, diastolic dysfunction was related to high body mass index, high body fat mass, and diabetes mellitus. CONCLUSION: The prevalences of diastolic abnormalities and diastolic dysfunction are higher than that of systolic dysfunction and are increased (despite age-dependent diagnostic criteria) in the elderly. However, in the absence of risk factors for diastolic abnormalities or diastolic dysfunction, namely LV hypertrophy, arterial hypertension, coronary artery disease, obesity and diabetes the condition is rare even in elderly subjects. These data allow speculation on whether diastolic heart failure may be prevented by improved implementation of measures directed against predisposing conditions.

Adult↗
PubMed2002

[In many hypertensive patients the systolic pressure remains uncontrolled. Is the selection of 140 mm Hg as the goal value too low?].

Despite the best preconditions, adequate control of arterial hypertension remains a stub born problem in the primary prevention area. Less than optimal control of hypertension is not confined to Germany--rather too low rates of detection and treatment have long been a problem for health care providers. But hypertensive treatment also inadequately succeeds in lowering systolic pressure to below the target level of 140 mmHg. Close study of the data provided by clinical trials also reveals that even intensified treatment, including the use of combinations of drugs and increased doses of antihypertensives, fails to reduce the systolic value to below 140 mmHg, while the elevated diastolic values can be brought down in more than 90% of the cases. These facts suggest that the practical significance of the target systolic value needs to be discussed. The wish to achieve the best possible control should not tempt us to close our eyes to the realistic potentials--and limitations--of medical care.

Adult↗
PubMed2002

Ten-year trends in smoking behaviour among adults in southern Germany.

SETTING: The city of Augsburg and two adjacent counties, covering a population of 532,987. OBJECTIVE: To provide a detailed description of trends in smoking behaviour among adults according to age, gender and educational status in southern Germany. DESIGN: Cross sectional surveys performed 10 years apart (1985 and 1995) in the Augsburg region as part of the WHO MONICA project. PARTICIPANTS: Of a total of 9261 eligible subjects, 7938 adults aged 25-64 years (4022 in 1985 and 3916 in 1995) from two separate random samples responded to the survey, giving a response rate of 79% in 1985 and 75% in 1995. RESULTS: In both surveys, daily smoking among men showed a clear pattern of reverse association with age and educational status, while women showed only an age-smoking pattern. Between 1985 and 1995, daily smoking showed a general increase among women and a decrease among men, with most of the increase in smoking prevalence as well as in numbers of cigarettes consumed by smokers occurring in women with a low level of education. Smoking cessation generally showed a positive relation to education in each survey for both sexes, and an increasing trend among all educational groups in the 10-year period between 1985 and 1995. CONCLUSION: The 10-year trends in smoking behaviour in southern Germany show features of early stage III of the smoking epidemic, where smoking is decreasing among men and continuing to rise among women, but with signs of levelling off in some social strata. Particular attention should be paid to combating smoking trends among women with low levels of education.

Adult↗
PubMed2001

[Risky high blood pressure, lipid and blood glucose values. Are blood pressure patients underserved?].

It is now generally accepted that the prognostic relevance of diastolic and systolic blood pressures varies with age. The probable explanation for this is considered to be the age-related hemodynamic changes in central and peripheral arteries. An analysis of 47,000 hypertensives reveals that a therapeutic strategy focused merely on lowering elevated blood pressure is inadequate. Since most hypertensives have multiple risk factors that are readily identifiable and treatable, a multifactorial therapeutic strategy is needed. Accordingly, modern treatment of hypertensives implies a predominant role for risk factor management. A European study on secondary prevention documents an unacceptably high prevalence of unhealthy lifestyles and poorly controlled blood pressure, lipid and glucose levels in patients with clinically diagnosed CHD. It is high time that scientific investigations be carried out to identify the reasons for the inadequate practical implementation of evidence-based preventive and therapeutic measures. It is to be expected that epidemiological investigations will help provide relevant data.

Coronary Disease↗
PubMed2001

Associations between homocysteine and coagulation factors--a cross-sectional study in two populations of central Europe.

Plasma homocysteine has been associated with vascular disease and mortality. Experimental studies and studies on patients with vascular disease have indicated a thrombogenic potential of raised homocysteine levels. Studies on community samples are rare. We investigated the associations between homocysteine levels and selected coagulation factors in population-based random samples of 187 men from Pardubice (Czech Republic) and 147 men from Augsburg (Germany), aged 45 to 64 years. Czech men had higher mean levels of plasma homocysteine (10.3 vs. 8.9 micromol/l, P<.001) and of fibrinogen, von Willebrand factor (vWF), prothrombin fragment 1+2 (F 1+2) and D-Dimer (each P<.05). Plasma homocysteine was positively correlated with fibrinogen (r=.34) and vWF (r=.23, each P<.001) only in Czechs, and with D-Dimer in both Czechs and Germans (r=.26 and.21, respectively). Formal testing for interaction regarding the intercountry differences in the relationship with homocysteine revealed significance only for fibrinogen (P<.01). In multivariate analyses, the association of homocysteine with D-Dimer remained statistically significant after adjustment for indicators of chronic inflammation and fibrinogen. No significant correlation was found with Factor VII (F VII) activity or F 1+2. Homocysteine levels were also unrelated to traditional risk factors. In conclusion, in these cross-sectional studies we found moderate to strong associations between homocysteine and components of the endogenous hemostatic and fibrinolytic systems. The associations were slightly different between Czech and German men. These findings may help to better understand the role of homocysteine in atherothrombotic diseases.

Blood Coagulation Factors↗
PubMed2001

Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design.

OBJECTIVES: The reason for the Study of Health in Pomerania (SHIP) is the lack of epidemiological studies with a broad range of health indicators. Furthermore, in Germany there is a need for studies that take into account the particular situation of life after the reunification. One objective of SHIP is to provide prevalence estimates on a broad range of diseases, risk and health factors for a defined region in the former GDR. METHODS: A sample of 7008 women and men aged 20 to 79 years in a north-east region of Germany, 4900 expected participants. The sample was drawn in two steps: First, 32 communities in the region were selected. Second, within the communities a simple random sample was drawn from residence registries, stratified by gender and age. The data collection and instruments include four parts: oral health examination, medical examination, health-related interview, and a health- and risk-factor-related questionnaire. The oral health examination includes the teeth, periodontium, oral mucosa, craniomandibular system, and prosthodontics. The medical examination includes blood pressure measurements, electrocardiography, echocardiography, carotid, thyroid and liver ultrasounds, neurological screening, blood and urine sampling. The computer-aided health-related interview includes cardiovascular symptoms, utilisation of medical services, health-related behaviours, and socioeconomic variables. The self-administered questionnaire comprises housing conditions, social network, work conditions, subjective well-being and individual consequences from the German reunification.

Adult↗
PubMed2001

Five year changes in waist circumference, body mass index and obesity in Augsburg, Germany.

AIMS: To assess temporal changes in body fat distribution, body mass index and obesity in Augsburg, Germany. METHODS: Waist circumference, weight and height were measured in two independent samples of 4804 and 4792, men and women, aged 25-74 years, in the MONICA Augsburg surveys 1989/90 and 1994/95. Abdominal obesity was defined as waist circumference greater than the 80th gender-specific percentile (men: 103, women: 92 cm) in the 1989/90 population. Obesity was defined as a body mass index (BMI) > or = 30 kg/m2. RESULTS: Age-standardized mean waist circumference increased by more than 1 cm (p-value < 0.00003) in both men and women while BMI increased by 0.3-0.4 kg/m2 (p-value < 0.01). We observed both a shift to higher values in the waist circumference distribution plus--particularly in women older than 45 years --a substantial right shift in the top of the distribution. Moreover, survey participants in 1994/95 who were at the higher end of the BMI distributions were disproportionately more obese than their respective peers in 1989/90. The prevalence of abdominal obesity rose by 3.3% in men and 3.6% in women, while the prevalence of obesity rose by 2% from 17% in men and by 2.5% from 19% in women. CONCLUSIONS: While changes in the Augsburg population may not be as alarming as in other countries, the secular increase in waist circumferences in both men and women occurring over a short time period indicates a need for prevention given the already high absolute weight, BMI and waist circumference levels in the population.

Adult↗
PubMed2001

Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction.

OBJECTIVE: A polymorphism at position 825(C-->T) of the G protein beta3 (GNB3) gene was found to be associated with enhanced transmembrane signalling as well as with an increased prevalence of arterial hypertension. The aim of the present study was to further investigate the association of the GNB3 C825T allele status with arterial hypertension in a large population-based sample and its association with specific end organ damage, i.e. myocardial infarction (MI). METHODS: Individuals from a population-based sample (n=2052) and patients suffering from premature MI (age at first MI < or = 60 years, n = 606) were studied by questionnaire as well as by physical examination and biochemical analyses. RESULTS: In the population-based sample, the prevalence of arterial hypertension (blood pressure > or = 160/95 mmHg and/or antihypertensive medication) was higher in individuals with the TT genotype (41.8%) as compared to heterozygote individuals (36.6%) or those with the CC genotype (32.75%) (P = 0.02). This association was predominantly found in men. Moreover, men without antihypertensive medication carrying the TT genotype showed higher diastolic blood pressure than those carrying the CC genotype (86.5 vs. 83.7 mmHg, P = 0.04). However, the genotype distribution and the allele frequencies were similar in both, the population-based and the MI patient sample. Furthermore, neither the age at the time of MI nor the location of the MI were related to the genotype distribution. Similarly, gender and age stratified analyses did not show any association of the GNB3 genotype and MI. CONCLUSIONS: In male individuals from a large population-based sample, the T allele of the GNB3 polymorphism was associated with arterial hypertension. However, the effects of the GNB3 825T allele on blood pressure were small and did not translate to a clinically relevant increase of risk for MI.

Antihypertensive Agents↗
PubMed2001

Smoking, other risk factors and fibrinogen levels. evidence of effect modification.

PURPOSE: Recent investigations have indicated that smoking may act as an important modifier of the risk associated with dyslipidemia. We hypothesized as a potential mechanism that smoking modifies the association between traditional risk factors of early atherosclerosis, such as dyslipidemia, hypertension, or diabetes, with fibrinogen, a risk factor more closely related to plaque progression and thrombosis. METHODS: The sample for this cross-sectional study, was collected from the MONICA Augsburg population survey of 1989/90 and included 1840 men and 1784 women, aged 25 to 64 years. Traditional risk factors hypertension, diabetes mellitus, and dyslipidemia were assessed by personal interviews, and medical examinations. Plasma fibrinogen concentration was determined by nephelometry. Effect modification was assessed by stratified analyses and tests for statistical interaction. RESULTS: Fibrinogen levels were higher in women than in men and, after adjustment for potential confounders, higher in smokers than in nonsmokers (each p < 0.001). The effect of smoking was greater in men (p < 0.001). The elevation of mean adjusted fibrinogen levels associated with hypertension or with diabetes in men was significantly higher in smokers as compared to nonsmokers (test for interaction, p < 0.001). By contrast, smoking in women showed significantly stronger impacts only with regard to the association of dyslipidemia and fibrinogen (p < 0.001). Comparing groups of subjects with increasing numbers of concomitant risk factors, stratified according to their smoking status, effect modification by smoking was particularly evident in male participants with two or more risk factors. Numbers of women with more than one risk factor and smoking were too low for analysis. CONCLUSIONS: We demonstrate that smoking contributes more than additively to the strong influences of single and combined traditional risk factors on fibrinogen levels. These data confirm that smoking is a dominant determinant of fibrinogen levels in the general population.

Adult↗
PubMed2001

Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study.

BACKGROUND: Ewing tumor treatment involves high cumulative doses of alkylating agents and topoisomerase inhibitors, drugs capable of inducing second cancers. We analyzed the second cancer risk in a large cohort of consistently treated patients. PATIENTS AND METHODS: Six hundred ninety Ewing tumor patients were treated between 1992 and 1999 with local therapy and vincristine. doxorubicin, ifosfamide and/or cyclophosphamide, and antinomycin D, with or without etoposide as a randomized question. Second cancer incidences were estimated by competing risk analyses; standardized incidence ratios (SIR) in comparison to registry data were compiled. RESULTS: After a median observation time of 56 months (32 months for survivors), 6 of 690 patients had developed second cancers: MDS/AML, two, ALL/NHL, two, squamous cell carcinoma, one, liposarcoma, one. SIR were increased 20-30 fold in comparison to the general population. The cumulative second cancer risk five years after diagnosis of the Ewing tumor was 0.0093 for the total group, zero for patients without etoposide, and 0.0118 with etoposide. Additional phase II high-dose therapy increased the risk to 0.0398 after five years. CONCLUSIONS: The second cancder risk observed was in the range to be expected in cancer survivors. High-dose therapy, and less markedly, etoposide, may contribute to the overall second cancer risk.

Adolescent↗