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Biomedical subjects

H W Horne

Publications and source records attributed to H W Horne.

At least 19 recordsLinked to original sources
PubMed1985

Evidence of improved pregnancy outcome with diethylstilbestrol (DES) treatment of women with previous pregnancy failures: a retrospective analysis.

In a longitudinal study of 2378 pregnancies, diethylstilbestrol (DES) therapy was associated with an increased live-birth rate in patients with a history of prior pregnancy wastage. The data were analyzed statistically by comparing the rates of success with and without DES treatment in pregnancies grouped according to similar reproductive histories. The effect of DES on the outcome of pregnancy has not been assessed previously in this manner.

Abortion, Threatened↗
PubMed1980

The role of mycoplasma among 81 consecutive pregnancies: a prospective study.

1. Among 41 previously positive and treated pregnant patients who were retreated when pregnant, the fetal wastage was 15%. 2. Among 40 previously negative or never cultured pregnant patients, the fetal wastage was 25%. 3. The incidence of previous major fertility surgery was 32% for the previously positive patients, but only 7% for the previously negative patients. 4. All of the 43 1-year-old children whose mothers received Vibramycin during early pregnancy have now been reported to be normal.

Doxycycline↗
PubMed1979

Survival of Ureaplasma urealyticum on different kinds of swabs.

The survival of Ureaplasma urealyticum on five different types of swabs routinely used for obtaining clinical specimens is limited to 1 h. Wooden applicator sticks inhibit the alkaline color change in broth and result in a significant loss of isolates if broth alone is used.

Humans↗
PubMed1976

Tetracycline-resistant T-mycoplasmas (Ureaplasma urealyticum) from patients with a history of reproductive failure.

The susceptibilities of T-mycoplasmas (Ureaplasma urealyticum) to minocycline, demeclocycline, doxycycline, tetracycline, and erythromycin were determined by a direct tube dilution test. T-mycoplasma-positive urine sediments of 105 patients with a history of reproductive failure were used as inocula. Minocycline was found to be the most active of the group of antibiotics commonly used to eradicate T-mycoplasma infection. Based on the median initial minimum inhibitory concentration, minocycline was the lowest with 0.03 mug/ml, followed by demeclocycline and doxycycline with 0.125 mug/ml, tetracycline with 0.25 mug/ml, and erythromycin with 2.0 mug/ml. Six T-mycoplasma isolates which had been cloned three times were also tested for susceptibility to the same five antibiotics. The same susceptibility pattern was found. Strains resistant to high concentrations of all antibiotics occurred. Strong positive correlation was seen in 21 patients between in vitro highly resistant strains and positive posttreatment cultures. These results indicate that empirical treatment of genital mycoplasma infections is not justified. Cultures should be taken pretreatment, susceptibility testing performed prior to treatment, and follow-up cultures done posttreatment.

Drug Resistance, Microbial↗