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Biomedical subjects

H W Klein

Publications and source records attributed to H W Klein.

52 records · Page 3Linked to original sources
PubMed1977

Normal internal calibres of ostia of great arteries and of aortic isthmus in infants and children.

In order to obtain reference data, useful in paediatric cardiology and paediatric cardiovascular surgery, internal diameters of the ostia of the great arteries, of the aortic isthmus, and of the descending aorta were determined with the aid of calibrated probes in 46 necropsy specimens of normal hearts with great vessels. Age range was from 25 weeks of gestational age up to 9 years post partum. The method used proved to be as accurate as echocardiography in vivo. The data revealed linear correlations between body length and calibres of aortic and pulmonary ostia. The correlation between the calibres of the pulmonary and the aortic ostia was also a linear one with the pulmonary ostium being slightly larger than the aortic ostium. From the cross-sectional areas of the aortic isthmus and of the descending aorta an isthmus index was calculated which indicates the presence (and degree) or absence of a narrowing (tubular hypoplasia) of the aortic isthmus. Results show that narrowing of the aortic isthmus is inconstantly present in infants younger than 10 weeks, whereas it is always absent in infants and children older than 10 weeks. No dependence of narrowing of the aortic isthmus on developmental age attained at birth has been found.

Anthropometry↗
PubMed1976

A human embryo of 28 mm crown-rump length with cerebral, esophagotracheal and cardiovascular malformations.

The following malformations were observed in a human embryo of 28 mm crown-rump length obtained at operation for tubal rupture in a case of extrauterine pregnancy: 1. Secondary anophthalmia with dysplasia and in part aplasia of the diencephalon. Rudiments of both eyes and eyestalklike proliferations within the diencephalon. No lenses and on the left side only a palpebral fissure. Hypoplasia of the right telencephalic hemisphere and of the right side of diencephalon, mesencephalon and proximal parts of the medulla oblongata. Pseudotumorous proliferations in the diencephalon, in the alar plate of the medulla oblongata (protruding into the fourth ventricle) and in the arachnoid. Hypoplasia of the right internal, middle, and external ear. Dysplasia and in part aplasia of facial osseous elements (cebocephalia). 2. Proximal esophageal atresia with distal tracheoesophageal fistula. 3. A Fallot's tetralogy with right-sided aortic arch and regressive right-sided ductus arteriosus, tricuspid atresia, hypoplasia of the right ventricle with excessive hypertrophy of its wall, and hypoplasia of the pulmonary trunk. Single left superior vena cava and abnormal, semicircular course of the stems of both coronary arteries.

Abnormalities, Multiple↗
PubMed1975

Coronary and endocardial fibroelastosis of the ventricles in the hypoplastic left and right heart syndromes.

In an autopsy material of 29 cases of the hypoplastic left heart syndrome coronary fibroelastosis was found in 1 case, endocardial fibroelastosis in 8 cases. Figures for 10 cases of the hypoplastic right heart syndrome were 6 cases of coronary fibroelastosis and 1 case of endocardial fibroelastosis. Age ranged from stillborn up to 11-1/2 months. Coronary and endocardial fibroelastosis seemed to be mutually exclusive localizations of congenital fibroelastosis since in our material they did not occur together in the same hearts. In hypoplastic right hearts coronary fibroelastosis was either restricted to the right coronary artery (right circumflex and posterior interventricular branch), or it was found also in the left coronary artery (anterior interventricular branch), with the most serve affections always being situated in the right one. In the only case of coronary fibroelastosis among the hypoplastic left hearts the condition was limited to the anterior interventricular branch of the left coronary artery which communicated with the hypoplastic left ventricle by a fistula. Coronary fibroelastosis was exclusively found in branches supplying the hypoplastic right ventricle and/or in a branch connected by a fistula to the hypoplastic left or right ventricle. Endocardial fibroelastosis was generally found in hypoplastic left ventricles with either no outflow or with severe outflow obstruction. A theory concerning the aetiology of both coronary and endocardial fibroelastosis of the hypoplastic ventricles is proposed. It is argued that development of fibroelastosis may in both localizations be caused or favoured by the coincidence of two factors: abnormal haemodynamic conditions and poor oxygenation of blood and tissues. Observations made in a reference material of 35 hypoplastic left and 24 hypoplastic right hearts were in accordance with this view.

Arteries↗
PubMedDate not supplied

Salvage of both lower extremities using simultaneous bilateral gastrocnemius and soleus muscle flaps: a case report.

We present a case of bilateral lower limb salvage in a young man with extensively exposed tibial bone following thermal injury. The medial head of the respective gastrocnemius muscle was used to cover the proximal third of debrided tibia, and the soleus muscle was used for the middle third coverage of each leg. This provided adequate, stable soft-tissue coverage for full recovery of both extremities and sufficient residual function for unassisted ambulation six months postoperatively.

Adult↗