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Biomedical subjects

H W Mauser

Publications and source records attributed to H W Mauser.

At least 19 recordsLinked to original sources
PubMed2003

Operative management of carotid artery in-stent restenosis: first experiences and duplex follow-up.

OBJECTIVES: Carotid Artery Stenting (CAS) may be comparable to Carotid Endarterectomy (CEA) as a durable and effective procedure in stroke prevention. Concern remains about the incidence of restenosis after stenting and its management. We evaluated the surgical management of restenosis after CAS. DESIGN: prospective study. METHODS: between December 1997 and April 2001, 217 CAS procedures were performed in 217 patients (155 men and 62 women; age 70 years +/- 8.2). After a mean of 8 months post-stenting four patients (two symptomatic, two asymptomatic with contralateral occlusion) with severe haemodynamic in-stent restenosis (90-99%) had surgical reintervention. RESULTS: standard CEA with removal of the stent was performed in all four patients. No major complications occurred. Intima hyperplasia showed to be the predominant mechanism leading to in-stent restenosis. All four surgically treated patients remained asymptomatic and without recurrent restenosis over a mean follow-up time of 13 months (range 3-20 months). CONCLUSION: the optimal treatment of in-stent restenosis has yet to be defined, but standard CEA with removement of the stent appears to be feasible.

Aged↗
PubMed2003

Restenosis after carotid angioplasty and stenting: a follow-up study with duplex ultrasonography.

OBJECTIVES: To prospectively document the incidence, location, risk factors for and clinical consequences of restenosis after carotid artery angioplasty and stenting (CAS). METHODS: Serial duplex and neurological examinations were performed in 217 patients one day (n = 216), 3 (n = 189), 12 (n = 129) and 24 (n = 48) months, after CAS. The relationship between patient, lesion and procedure variables and restenosis was determined at 12 months. RESULTS: The prevalence of restenosis > or = 50% was 14, 16, 18, and 21%, respectively, and was only significantly related with loss of proximal stent apposition (odds ratio 3.4, 95% confidence interval: 1.0-11.7, p < 0.05). Four restenoses were symptomatic. CONCLUSIONS: Restenosis after CAS is common, unpredictable but infrequently symptomatic.

Aged↗
PubMed2001

[An infant with pain and meningeal irritation due to Guillain-Barré syndrome].

In a five-month-old girl, who for a week had cried and displayed a relapse in the motor development, generalised hypotonia and meningism were found. Eventually, the results of the cerebrospinal fluid analysis and electromyography indicated Guillain-Barré syndrome. She was treated with immunoglobulins and made a quick recovery. Guillain-Barré syndrome is an acute or subacute inflammatory demyelinating polyradiculoneuropathy that can occur at any age. In children, the classic symptoms such as a flaccid paralysis and areflexia are not always predominant. Instead, pain is often the most prominent symptom, along with meningism. These symptoms are often insufficiently recognised in practice and as a result of this, delays in the diagnosis of this potentially life-threatening disease often occur.

Diagnosis, Differential↗
PubMed2001

Stroke from carotid endarterectomy: when and how to reduce perioperative stroke rate?

OBJECTIVES: To analyse four years of CEA with respect to the underlying mechanisms of perioperative stroke and the role of intraoperative monitoring in the prevention of stroke. PATIENTS AND METHODS: From January 1996 through December 1999, 599 CEAs were performed in 404 men and 195 women (mean age: 65 years, range: 39-88). All operations were performed under general anaesthesia using computerised electroencephalography (EEG) and transcranial Doppler (TCD). Any new or any extension of an existing focal cerebral deficit, as well as stroke-related death were registered. Perioperative strokes were classified by time of onset (intraoperative or postoperative), outcome (minor or major stroke), and side (ipsilateral or contralateral). Stroke aetiology was assessed intraoperatively by means of EEG, TCD, completion arteriography or immediate re-exploration, and postoperatively by duplex sonography, computerised tomography (CT) or magnetic resonance imaging (MRI) of the head. RESULTS: Perioperative stroke or death occurred in 20 (3.3%) patients. In four operations stroke was apparent immediately after surgery. Mechanisms of these strokes were ipsilateral carotid artery occlusion (1) and embolisation (3). In 16 patients stroke developed after a symptom-free interval (2-72 h, mean 18 h) due to occlusion of the internal carotid artery on the side of surgery (9). Other mechanisms were: contralateral occlusion of the internal carotid artery (1), postoperative hyperperfusion syndrome (1), intracerebral haemorrhage (1), and contralateral ischaemia due to prolonged clamping (1). In three procedures the cause was unknown. CONCLUSIONS: In our experience most strokes from CEA developed after a symptom-free interval and mainly due to thromboembolism of the operated artery. We suggest the introduction of additional TCD monitoring during the immediate postoperative phase.

Adult↗
PubMed1999

Bilateral sequential facial palsy during chickenpox.

UNLABELLED: Facial palsy is a rare neurological complication of chickenpox. A 5-year-old girl exhibited a right facial palsy followed by the appearance of the characteristic chicken pox exanthem. Subsequently she suffered a left facial palsy. In this patient both pathophysiological mechanisms responsible and their relation to the phase of infection are illustrated. CONCLUSION: Facial palsy as a complication of chickenpox can result from pre-eruptive haematogenous or neurogenous spread of varicella-zoster virus.

Antibodies, Viral↗
PubMed1995

The significance of microemboli detection by means of transcranial Doppler ultrasonography monitoring in carotid endarterectomy.

PURPOSE: Carotid endarterectomy (CEA) performed with continuous transcranial Doppler monitoring provides a unique opportunity to determine the number of cerebral microemboli and to relate their occurrence to the surgical technique. The purpose of this study was to assess in CEA the impact of cerebral microembolism on clinical outcome and brain architecture. We also evaluated the influence of the audible transcranial Doppler signal on the surgeon and his or her technique. METHODS: In a prospective series of 301 patients, CEA was monitored with electroencephalography and transcranial Doppler ultrasonography of the ipsilateral middle cerebral artery. Preoperative and intraoperative risk factors were entered in a logistic regression analysis program to assess their correlation with cerebral outcome. To evaluate the impact of cerebral microembolism on brain architecture, we compared preoperative and postoperative computed tomography scans or magnetic resonance images of the brain in two subgroups of 58 and 40 patients, respectively. RESULTS: Seven (2.3%) patients had intraoperative transient ischemic symptoms, three (1%) had intraoperative strokes, 1 (0.3%) had transient ischemic symptoms after operation, and 10 (3.3%) had postoperative strokes. Four (1.3%) patients died. Microemboli (> 10) noticed during dissection were related to both intraoperative (p < 0.002) and postoperative (p < 0.02) cerebral complications. Microemboli that occurred during shunting were also related to intraoperative complications (p < 0.007). Microembolism never resulted in new morphologic changes on postoperative computed tomography scans. On the contrary, the phenomenon of more than 10 microemboli during dissection was significantly (p < 0.005) related to new hyperintense lesions on postoperative T2-weighted magnetic resonance images. CONCLUSIONS: During CEA the presence of microembolism (> 10 microemboli) during dissection shows a statistically significant relationship with perioperative cerebral complications and with new ischemic lesions on magnetic resonance images of the brain. Moreover, microembolism during shunting is also related to intraoperative complications. Surgeons can be guided by the audio Doppler and emboli signals by changing their technique. This change may result in a decrease of microembolism and consequently in a decline of the intraoperative stroke rate.

Adult↗
PubMed1995

Detection of cerebral microemboli by means of transcranial Doppler monitoring before and after carotid endarterectomy.

BACKGROUND AND PURPOSE: The main purpose of carotid endarterectomy (CEA) for neurologically symptomatic high-grade extracranial carotid artery stenosis is to remove the suspected source of cerebral microemboli. Transcranial Doppler (TCD) ultrasonography has the potential for detecting solid microemboli in the basal cerebral arteries. Therefore, TCD monitoring provides the opportunity to assess the rate of microemboli to the brain in patients with symptomatic high-grade carotid artery stenosis and to verify whether these phenomena have ceased after CEA. METHODS: TCD monitoring was performed in 41 patients to detect high-intensity transient signals indicating microemboli in the middle cerebral artery before and after CEA. In the event that, within 1 week after CEA, TCD monitoring revealed ongoing cerebral microemboli on the side of surgery, the examination was repeated 3 months later. RESULTS: High-intensity transient signals were detected preoperatively on the side of the affected carotid artery in 22 patients (54%; mean, 10.2 per hour; range, 1 to 88). Linear regression analysis demonstrated a trend toward an inverse relationship between the number of high-intensity transient signals per hour and the time interval since the last episode of neurological symptoms (P < .1). CEA resulted in a significant reduction in the number of high-intensity transient signals per hour 7 days after surgery (mean, 6.0 versus 0.4 per hour; median, 0 versus 0; n = 37; P < .005) and 3 months later (mean, 6.3 versus 0 per hour; median, 1.3 versus 0; n = 41; P < .0001). CONCLUSIONS: Clearly, TCD monitoring can be helpful in assessing the effect of CEA in removing the suspected source of cerebral microemboli. Ongoing microemboli to the brain should prompt reassessment of the operated carotid artery or a search for other potential sources of cerebral embolism. Carotid artery plaques seem to produce cerebral microemboli for a limited period, which implies that the prophylactic effect of CEA might decrease if the operation is delayed.

Adult↗
PubMed1988

Migrant sensory neuritis of Wartenberg. A case history.

A case history of a patient with a Migrant sensory neuritis of Wartenberg is presented. In this syndrome several isolated cutaneous nerves are affected, apparently due to traction lesions. This benign disease should be differentiated from other, more serious neurological diseases.

Adult↗
PubMed1987

Factors affecting the outcome in subdural empyema.

The case reports of 102 patients with subdural empyema, diagnosed in the years 1935-83, were reviewed to determine the factors affecting the outcome. Statistical analysis (likelihood ratio tests with chi square approximation and logistic regression) showed that year of diagnosis (p less than 0.01) and level of consciousness at the moment of diagnosis (p less than 0.01) had a significant bearing on the chance to survive and that these same two factors (each factor p less than 0.01) and extent of subdural pus accumulation at the moment of diagnosis (p less than 0.05) had a significant bearing on the chance of survival without severe disability. Among others the duration of the disease up to the moment of diagnosis and the mode of the first surgical procedure had no significant bearing on the outcome. These results together with those in the literature are discussed and it is concluded that diagnosis and treatment before the patient lapses into stupor or coma, increases the chance of survival and that with adequate management a mortality rate of 10% or lower is to be expected.

Anti-Bacterial Agents↗
PubMed1986

The EEG in the diagnosis of subdural empyema.

The EEG findings in 9 patients with a subdural empyema are reported. In all cases the EEG, recorded before the diagnosis had been established, contained focal zeta waves, extensive unilateral depression of cortical activity and, in all but one, a diffuse slowing of the background activity. This combination has not been reported before in the literature and it is concluded that in its presence the existence of a subdural empyema should be seriously considered. Comparison with CT scan findings in 3 cases indicated that sometimes EEG may be more sensitive than CT scanning in the diagnosis of subdural empyema. The value of EEG and CT scan in the diagnosis of patients presenting with an acute or subacute bacterial meningo-encephalitis is briefly discussed.

Adolescent↗
PubMed1986

MRI in neurosurgical diagnosis and management of craniocervical junction and cervical spine pathology.

Thirty-six patients with pathology in the area of the craniocervical junction and the cervical spine have been studied with Magnetic Resonance Imaging (MRI), using the Inversion Recovery and Spin-Echo technique. The value of MRI for diagnosis and management is compared, in retrospect, to X-ray Computer Tomography and Myelography. The conclusion is that MRI can replace CT and myelography in the clinical evaluation of many patients with pathology of the craniocervical junction and the cervical spine.

Adult↗
PubMed1985

Conservative and surgical management of focal cerebral infection.

After the introduction of CT-scanning the management of focal cerebral infections has been modified. Based on the data of two patients and on the literature the authors discuss the choice between fully conservative, immediately neurosurgical or delayed neurosurgical treatment. It is the author's opinion that by closely following the infectious process too early neurosurgical intervention can be avoided and thus unnecessary sacrifice of viable neural tissue.

Adolescent↗
PubMed1985

Nonsurgical treatment of subdural empyema. Case report.

The nonsurgical treatment of a case of interhemispheric subdural empyema is reported. At the time of diagnosis, the patient had a mild decrease in consciousness and only moderate focal neurological deficits. Computerized tomography (CT) confirmed the limited (interhemispheric) extent of the intracranial infection. After drainage of the nasal sinuses and antibiotic treatment, the patient recovered, although the lesion was initially increased in size on CT scanning.

Adult↗