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Biomedical subjects

H W Pabst

Publications and source records attributed to H W Pabst.

At least 91 records · Page 5Linked to original sources
PubMed1976

Experience with 201 thallium in detection of myocardial infarction.

Our preliminary experimental and clinical results with 201Tl myocardial scanning are presented. 48 patients with normal coronary vessels, acute trasmural myocardial infarction, localized and diffuse coronary heart diseases and congestive myocardiopathy were investigated. Results of scans and the usual cardiological investigations were in good agreement thus justifying further use of 201Tl myocardial scintigraphy as an adjunctive method in cardiology.

Animals↗
PubMed1976

[Clinical and experimental investigations with 201tl for noninvasive myocardial scintigraphy (author's transl)].

The biological distribution of 201Tl after intravenous injection was studied experimentally in 42 rats. It was found (see figure 1) that the kidneys showed the greatest affinity for 201Th, reaching an activity concentration of 6.6% per gramme of tissue, almost independently of time. Within the first 30 minutes of injection, myocardial activity exceeds that of the surrounding structures (10 min. p.i.: 4.24%/g; 30 min. p.i.: 2.58%/g). During this time the myocardium can be well demonstrated by "image processing". The relatively fast myocardial kinetics of 201Tl (half value time 33 minutes) make it necessary, strictly speaking, to use a scintillation camera. The clinical value of this method is illustrated by a number of case histories.

Animals↗
PubMed1975

[Comparison of results of 99mTc-polyphosphate-camera-(sequence functional)-scintigraphy, 85Sr-, 87mSr-scanner-scintigraphy, and of radiologic methods in orthopedics].

Comparative studies between radiological (equals R; x-ray, thermography, angiography) and nuclear medical examinations (equals NM; scanner-, scintillation camera-sequential scintigraphy) in 339 patients with different bone diseases led to the following results: Thermography proved to be inferior to scanning in detecting of bone diseases. Angiography was the procedure of choice in detecting malignant bone tumors. Sequential scintigraphy performed by means of the Anger-HP-scintillation camera and Intertechnique-Cine-System allowed to establish the kinetic behaviour of tumors: an early increased TcPoP accumulation was observed in tumors with high perfusion (sarcoma), a late accumulation in those with low perfusion (osteoid osteoma).

Angiography↗
PubMed1975

[Diagnosis of pancreatic function by the selenomethionine--75Se test].

Dterminations of 75selenium radioactivity and pancreatic enzyme in duodenal aspirate were carried out in 50 patients after i. v. injection of selenomethionine-75Se. After standardized excitation of the pancreas with pancreozymin-secretin, a significant correlation (r = 0.654) between excreted 75Se radioactivity and trypsin production could be established. The test is suitable for the recording of exocrine pancreas function while avoiding expensive enzymatic methods. The combined use of pancreas scintigraphy--using the double radionuclide substraction technique-with the radioselenomethionine test (RSMT) provides comprehensive diagnostic information on the morphology and function of the pancreas.

Amylases↗
PubMed1975

[Results of HPL radioimmunoassay in normal and pathologic early pregnancy].

Radioimmunological assays of HPL have been carried out in early pregnancy in uncomplicated cases (n = 100) and in cases of abortus imminens (n = 49). The earliest detection of HPL was possible in the 6th week of pregnancy. When the tendency of the HPL-level was decreasing follow-up examination showed a beginning abortus. In every case of decreased HPL-level the progress of pregnancy was abnormal. Conclusions about the prognostic value and the limits of the HPL-RIA are discussed.

Abortion, Threatened↗
PubMed1975

[Measurement of renal blood flow with the Anger scintillation camera after selective intra-arterial injections of 133xenon and 99mtechnetium].

A "region of interest" technique for measuring renal blood flow is described, using as Anger camera and selective intra-arterial injection of 133Xe and 99mTc. The sequence of measurements has the advantage of providing information on regional blood flow. The values for RBF and RBFD obtained with 133Xe agree with those in the literature. Selective determination of the RCBF with the "region of interest" technique using 133Xe was not possible. Mean transit time for 99mTc was calculated after correction of the 99mTc indicator dilution curve with respect to recirculation and background activity. All typer of pathological changes in the kidney showed a statistically significant increase in mean transit time when compared with a control group. In patients with uncomplicated essential hypertension, the mean transit time was signigicantly reduced. A comparison of the mean transit time of 99mTc with the haemodynamic parameters derived from the 133Xe studies, and experiments with pharmocologically induced vasoconstriction indicates that the mean transit time represents a measure of the RCBF.

Adolescent↗