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Biomedical subjects

H W Ritter

Publications and source records attributed to H W Ritter.

6 recordsLinked to original sources
PubMed1977

Nitrones. 7. alpha-Quinoxalinyl-N-substituted nitrone 1,4-dioxides.

A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.

Animals↗
PubMed1976

Beta-lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides.

A series of penicillin derivatives of quinoxaline di-N-oxide carboxylic acids was prepared. These compounds were prepared from the acid chlorides and mixed anhydrides of the quinoxaline di-N-oxides. The compounds prepared exhibited minimal antibacterial activity against gram-negative organisms.

Animals↗
PubMed1975

3-Substituted 2-formylquinoxaline 1,4-dioxides.

The methylnitrone of 3-methyl-1,4-dioxidoquinoxaline-2-carboxaldehyde (1) has been exceptional antibacterial activity in vivo. Derivatives of 3-hydroxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde and 3-acetoxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as I.

Animals↗