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Biomedical subjects

H W Steer

Publications and source records attributed to H W Steer.

10 recordsLinked to original sources
PubMed1976

Mast cells of the human stomach.

Mast cells were examined from various sites in the normal human stomach and in the stomachs of patients with gastric ulceration. The distribution of the different types of mast cell granules was determined in the subepithelial region of the normal human stomach. There was a significant difference in this respect between the mast cells at the incisura angularis as compared with those high on the lesser curve or high on the greater curve. Mast cell degranulation (i.e. the shedding of intact granules) and vacuolation were examined with the electron microscope. Degranulation and vacuolation were observed in subepithelial mast cells, whereas only vacuolation was seen in intraepithelial mast cells. The significance of degranulation and vacuolation is discussed.

Gastric Mucosa↗
PubMed1975

Melanosis coli: studies of the toxic effects of irritant purgatives.

Colonic biopsies from six patients with normal colons and seven patients with melanosis coli were studied ultrastructurally and histochemically for lysosomal enzymes. Anthraquinone purgatives were found to increase the number of macrophages in the connective tissue of the colonic mucosa. In addition, they cause an increase in the intensity of lysosomal activity and an increase in the number of lysosomes in macrophages, Schwann cells and neurones of the submucosal plexus of the colonic mucosa.

Adult↗
PubMed1975

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of intraepithelial polymorphonuclear leucocytes before and after successful treatment with carbenoxolone sodium. There is also a statistically significant decrease in the quantity of intraepithelial lymphocytes in those patients with lesser curve gastric ulcers successfully treated with carbenoxolone sodium, whereas there is a significant increase in those patients with prepyloric gastric ulcers successfully treated and those patients in whom treatment failed. The value of counts of migrating white blood cells as a method of objectively assessing the effect of healing drugs upon the gastric mucosa is discussed. Pseudomonas aeruginosa was found in many specimens obtained, and evidence is presented that this was not a contaminant. Carbenoxolone appeared to increase the amount of mucus but had little effect upon the number of bacteria found. The possible contribution of Pseudomonas aeruginosa to gastric ulceration is discussed.

Biopsy↗
PubMed1975

The pseudomembranous colitis associated with clindamycin therapy--a viral colitis.

Four patients are described who developed pseudomembranous colitis in association with clindamycin therapy. Rectal biopsies from two patients were studied with the electron microscope and compared with the ultrastructural appearance of the rectal mucosa from seven normal people. Ultrastructural evidence for a viral colitis was obtained. The significance of the clindamycin therapy to the viral colitis and the contribution of the viral colitis to the clinical state are discussed.

Adult↗
PubMed1975

A prospective comparative trial between early endoscopy and radiology in acute upper gastrointestinal haemorrhage.

A prospective comparative trial is reported between the results of early endoscopy and barium meal examinations in 150 patients admitted with acute upper gastrointestinal haemorrhage. One hundred and thirty-eight patients underwent both investigations within 24 hours of admission. Emergency endoscopy accurately identified the source of haemorrhage in 86% of patients and emergency radiology identified the source in 51%. Misleading positive reports were given endoscopically in 3% and by barium meal in 8%. The identification of the source of haemorrhage was possible in 126 patients (91%) by the use of both methods. Emergency endoscopy is shown to be superior to emergency barium meal examination, but the examinations are complementary and both should be used for these patients.

Acute Disease↗
PubMed1975

Ultrastructure of cell migration throught the gastric epithelium and its relationship to bacteria.

The migration of polymorphonuclear leucocytes and lymphocytes through the gastric mucosa has been studied with the electron microscope. Bacteria have been found related to the gastric epithelium. Arguments in favour of these bacteria not being contaminants at the time that the biopsies were taken are presented. The relationship between polymorphonuclear leucocyte migration and the occurrence of bacteria is discussed.

Bacteria↗