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Biomedical subjects

H W Sumner

Publications and source records attributed to H W Sumner.

27 records · Page 2Linked to original sources
PubMed1976

The single palpable thyroid nodule: evaluation by 99mTc-pertechnetate imaging.

The role of 99mTc-pertechnetate thyroid imaging in the preoperative assessment of patients with single palpable thyroid nodules was evaluated. The frequency of cancer in hypofunctional nodules was similar to that found in previous studies with 131I. The 99mTc-pertechnetate image allowed a reliable separation of pathologically uninodular thyroids from those that were multinodular, and demonstrated multiple thyroid lesions that had not been detected by physical examination in over one-third of the cases. The frequency of cancer in thyroids containing a solitary or dominant hypofunctional nodule was higher (17%) than that in thyroids with a multinodular scan appearance (less than 5%).

Adolescent↗
PubMed1976

Angiosarcoma of the skin. A clinicopathologic and fine structural study.

A study of ten cutaneous angiosarcomas is presented. These tumors characteristically involve the scalp or face of elderly individuals, where they present as bluish or violaceous plaques and nodules. They have a marked tendency for local spread in surface and depth, and a third of them eventually give rise to distant metastases, particularly to cervical lymph nodes and lung. Microscopically, angiomatous areas of freely anastomosing channels lined by atypical endothelial cells are seen alternating with Kaposi-like spindle cell areas and undifferentiated foci. By electron microscopy, the tumor cells are seen to have all the features of endothelial cells, including pinocytotic vesicles, tubulated bodies, and in one case closed fenestrations. They also exhibit a cytoplasmic specialization here interpreted as the intracellular formation of a vascular lumen. Pericytes and cells resembling smooth muscle cells are also present. In the differential diagnosis this entity has to be distinguished from other clinical types of angiosarcoma of the skin and from a number of benign and malignant conditions. It is suggested that surgery be used for solitary, well circumscribed tumors and radiation therapy for tumors that either are multicentric or have ill defined margins.

Aged↗
PubMed1976

Colitis cystica profunda.

Colitis cystica profunda is a benign disease characterized by variably sized mucin-filled cysts beneath the muscularis mucosae. The clinocpathologic features of five patients are described. The accumulated evidence suggests that awareness of this entity both by clinicians and pathologists with help differentiate it from carcinoma and decrease the need for radical surgery.

Adult↗
PubMed1975

Cricoid arch replacement in dogs. Further studies.

Published reports by Delahunty et al and Alonso et al described the feasibility of correcting subglottic defects with cricoid arch transplantation. Using normal dogs, satisfactory results, including airway patency and vocal cord function, were reported. This report describes a second series of dogs in which subglottic stenosis was first induced by an open procedure and was subsequently repaired with an allotransplanted cricoid arch. The resulting subglottic defect in the donor dogs was repaired by autogenous hyoid arch transposition. No immunosuppressive measures or stents were used in either group. The animals were followed for periods up to one year prior to histologic study. Satisfactory results were obtained in both groups.

Animals↗
PubMed1975

Hereditary hemorrhagic telangiectasia: presenting as an unusual gastric lesion.

A case of hereditary hemorrhagic telangiectasia, occuring in a 61-year-old male, presented as an ulcerating antral mass lesion and hepatosplenomegaly. The antral mass was demonstrated to be composed of a proliferation of blood vessels and is an unusual presentation for hereditary hemorrhagic telangiectasia of the gastrointestinal tract.

Diagnosis, Differential↗
PubMed1975

Rectal biopsy in clindamycin-associated colitis. An analysis of 23 cases.

The findings on rectal biopsy and proctoscopic examination in 23 cases of clindamycin-associated pseudomembranous colitis are summarized. On proctoscopic examination, discrete 2- to 5-mm raised plaques are seen adherent ot an edematous, friable mucosa. Rectal biopsy shows pseudomembrane formation and inflammation of the underlying rectal mucosa. Necrosis of the surface epithelium is a frequent finding; however, true ulcers were not observed. Vasculitis or thrombosis is not a feature of any of the cases. Frequently, the pseudomembrane is observed to be dislodged from the mucosal surface. In five of 23 cases, characteristic pseudomembranes are not present in the biopsy specimen in spite of the fact that they are evident proctoscopically.

Adolescent↗
PubMed1975

Angiosarcoma of the liver associated with Fowler's solution (potassium arsenite).

A patient with an angiosarcoma of the liver associated with the chronic ingestion of Fowler's solution (potassium arsenite) is described. The patient's clinical course was characterized by upper gastrointestinal hemorrhage, recurrent hemoperitoneum, hepatic failure, and, subsequently, the appearance of an angiosarcoma of the skin. Selective angiography demonstrated features consistent with both hepatoma and cavernous hemangioma. The hepatic toxicity and the carcinogenicity of arsenic are reviewed, with particular reference to Fowler's solution, which previously has been widely used for the treatment of psoriasis. The long latency period for the development of the malignancies is emphasized.

Adult↗
PubMedDate not supplied

Amyloid in a patient with Reiter's syndrome - secondary or coincidental? Differentiation with potassium permanganate.

A patient with Reiter's syndrome developed a pulmonary nodule composed of amyloid. Reiter's syndrome has been reported as 1 of the diseases associated with secondary systemic amyloidosis. Isolated nodular pulmonary amyloid has not been reported to become systemic. Potassium permanganate treatment of amyloid abolishes congo red stain affinity for amyloid of unknown origin found in secondary amyloidosis. However, the amyloid of immunoglobulin origin, characteristic of primary amyloid, is resistant to KMnO4. The amyloid deposit from our patient was resistant to KMnO4 which suggested that the pulmonary amyloid was a coincidental nodular amyloid deposit in the lung rather than secondary amyloidosis.

Amyloidosis↗