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Biomedical subjects

H W Toolan

Publications and source records attributed to H W Toolan.

At least 19 recordsLinked to original sources
PubMed1983

Degeneration of lens and overgrowth of Harderian glands in hamsters neonatally injected with parvovirus MVM-i.

Injection of newborn hamsters with 500 plaque-forming units or more of the parvovirus MVM-i, produces an eye defect in a large percentage of the treated animals at maturity. The incidence is directly related to the amount of virus given and is independent of sex, size, or antibody levels to MVM-i. The abnormality is characterized by very small eyes with degenerate lens and adjacent retinal layers, and also by such extensive hypertrophy of the Harderian glands that they may encase the orbit and occlude the eye. On the basis of this latter finding and of previous work by other investigators, we suggest that the glands, whose function is unknown, may act as accessory photoreceptors.

Aging↗
PubMed1982

Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors in Syrian hamsters by prior infection with H-1 parvovirus.

Hamsters, given injections s.c. at birth of H-1 parvovirus and 1 month later given a single injection of 7,12-dimethylbenz(a)anthracene, had a 38% tumor incidence compared with a 95% incidence in animals receiving 7,12-dimethylbenz(a)anthracene alone. Thus, H-1 which, it has already been shown, invokes a resistance to the incidence of spontaneous and adenovirus-induced neoplasms in hamsters also produces a suppression of a carcinogen-induced tumor in these animals; this suggests that the H-1-induced barrier to successful oncogenesis by these diverse agents has a common mechanism which, present experiments indicate, is not related to a positive or negative H-1 serology. The pathology of the 7,12-dimethylbenz(a)anthracene-induced tumors was similar for both control and H-1-infected hamsters. Although all but one of the primary neoplasms were anaplastic fibrosarcomas as reported previously by others, 25% of the affected females had, in addition, mammary adenocarcinomas, an extremely rare tumor in hamsters.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1972

The parvoviruses.

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Adenoviridae↗