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Biomedical subjects

H Wüst

Publications and source records attributed to H Wüst.

At least 19 recordsLinked to original sources
PubMed1988

Absorption and bioavailability of nebulized morphine.

During anaesthesia seven patients received a bolus of morphine 10 mg injected into the nebulization reservoir placed between the tracheal tube and the anaesthetic circle (IH). Five days after operation the same seven patients received morphine 10 mg i.m. On both occasions, venous blood samples were taken before and every 15 min after administration over 4.5 h for measurement of free morphine immunoreactivity by radioimmunoassay. There was marked individual variation in the serum morphine concentrations produced following each route of administration. The maximum serum morphine concentration following inhaled morphine was approx. six times lower than that after morphine i.m. and the time of occurrence differed significantly (P less than 0.001). The individual relative bioavailabilities of inhaled morphine varied from 9% to 35%, with a mean of 17%.

Absorption↗
PubMed1979

[Dose distribution of bone-seeking radiopharmaceuticals in the rat (author's transl)].

The biokinetics of 32P-P, 32P-PPi, 85Sr, 99mTc- and 113Sn-EHDP were evaluated in the young rat. The dose distribution of the beta-emitters 32P, 89Sr, 121Sn and 188Re was calculated from the measured biological half-lifes. The highest dose to soft tissues and therefore also to bone-marrow in relation to the bone dosis was found for 32P-P. The lowest dose was found for 89Sr. Favourable results were obtained in the diphosphonate compounds. The use of 32P-PPi instead of 32P-P appears to be advantageous, too. The dose relation between normal bone and the growth plate of the femur was significantly lower for 89Sr than for the other radiopharmaceuticals.

Animals↗
PubMed1978

Thin layer chromatographic screening for methaqualone, phenothiazines, opiates and benzodiazepines.

A method is described which permits the simultaneous detection of methaqualone, phenothiazines, opiates and benzodiazepines in urine. Its diagnostic application is discussed. After cleavage of conjugates with hydrochloric acid, the substances are extracted and identified by thin-layer chromatography. In most cases analysis can be carried out using 2 solvent systems, phenothiazines, methaqualone and opiates being visualised using a three stage spray sequence. Since phenothiazines can interfere with the detection of methaqualone, a specific eluant is used to ensure reliable detection of the latter. Methaqualone can be positively identified by its characteristic metabolite pattern, whereas phenothiazines can only be detected as a group.

Analgesics, Opioid↗
PubMed1978

[The effect of operation, anaesthesia and blood viscosity on haemodynamic during aortofemoral bypass operation (author's transl)].

Cardiac index, total peripheral resistance, blood, plasma and serum viscosity in patients with peripheral vascular disease were measured pre-, intra- and postoperatively. Besides plasma and serum viscosity, most obviously blood viscosity decreased during anaesthesia and operation. The decrease of blood viscosity is caused mainly by the falling haematocrit. Red blood cell aggregation occuring under low-flow conditions is decreased. Thus blood viscosity additionally is diminished at least in the area of low shear rates. Corresponding haemodynamic measurements revealed that decreasing viscosity improves cardiac index and total pressure resistance if normovolaemia exists, but in general is masked by anaesthesia and operation.

Anesthesia↗
PubMed1977

[Postoperative control of blood flow in arterial surgery: results of electromagnetic blood flow measurement (author's transl)].

An electromagnetic blood flow cuff probe was implanted up to 4 days in 50 patients to control basal blood flow through a femoro-popliteal vein graft. Patent grafts showed increasing blood flow due to hyperemia with maximum on the 2. p. op. day. The level of the postoperative hyperemia and the increase of blood flow caused by intraarterial papaverine injection during operation were in the same range. The method and the extension of analgesia influenced the degree of postoperative hyperemia. Pain and blood loss diminuished graft flow. Patients with epidural block and sufficient blood volume produced a significant higher graft flow than patients with morphine analgesia. 2 patients had early occlusion of the graft, 2 others showed occlusion at the distal anastomosis. These complications could be easily detected by blood flow measurement and were successfully corrected in two patients. Moreover, electromagnetic postoperative blood flow control may be helpful in patients with proximal a.v. shunt for hemodialysis.

Arterial Occlusive Diseases↗