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Biomedical subjects

H WESTLING

Publications and source records attributed to H WESTLING.

At least 55 records · Page 3Linked to original sources
PubMed1960

The effect of enzyme inhibitors on histamine catabolism in man.

The catabolism of histamine was studied in three female psychiatric patients by analysis of the [(14)C]-labelled metabolic products occurring in the urine after a subcutaneous injection of [(14)C]histamine. Each patient was studied before and during treatment with aminoguanidine or iproniazid.Without treatment the patients had a normal histamine catabolism. Aminoguanidine and iproniazid inhibited the oxidation of histamine to imidazoleacetic acid; iproniazid produed a 50% inhibition of the oxidation of methylhistamine to methylimidazoleacetic acid. After iproniazid a large proportion of the injected [C(14)]histamine was excreted as methyl [(14)C]histamine.

Amine Oxidase (Copper-Containing)↗
PubMed1958

The difference in the metabolism of injected [14C]histamine in male and female rats.

[(14)C]Histamine was injected subcutaneously in rats. The urine was collected for 24 hr. and analysed for [(14)C]histamine and its various metabolites. It was found that male rats excreted less unchanged [(14)C]histamine than female ones, the difference between the sexes existing also when the animals were treated with aminoguanidine. The cause of the sexual difference appeared to be that the male rats had a larger capacity to methylate histamine.

Animals↗