Biomedical subjects

H Wagnerova

Publications and source records attributed to H Wagnerova.

5 recordsLinked to original sources

PubMed2001

[Adrenal incidentalomas].

The extensive use and progress in the improvement of imaging techniques brings about the growing incidence of incidentalomas, i.e. adrenal lesions accidentally revealed during the imaging of the abdominal cavity which was originally focused on the visualisation of organs other than adrenal glands. Despite the fact than the majority of incidentalomas (55-91%) represent benign adrenocortical adenomas, it is necessary to focus the diagnostic approach on the exclusion of malignity and hormonal activity. However, no common consent has been yet achieved in the management of incidentalomas. The authors review the literature data on the prevalence, diagnosis (namely hormonal assessments as well as imaging methods) and the current suggestion of the necessity of further investigation and treatment of adrenal incidentalomas. (Tab. 1, Fig. 5, Ref. 64.)

Adrenal Gland Neoplasms↗

PubMed2001

[Effect of passive leg lifting on sodium excretion in patients with liver cirrhosis].

18 healthy subjects and 15 patients with liver cirrhosis were examined using a 2-hour method of passive leg rising (PLR). Renal and hormonal responses to PLR were investigated. There was a significant increase in diuresis (p < 0.01) and sodium excretion (p < 0.01) simultaneously with a decrease in plasma renin activity (p < 0.01) and plasma aldosterone (p < 0.01) in the group of healthy subjects. Similarly, in the group of patients with liver cirrhosis a significant increase in diuresis (p < 0.01), natriuresis (p < 0.05) together with a decrease in plasma renin activity (p < 0.05) and aldosterone (p < 0.01) were detected. 3 of 15 patients were nonrespondents. We conclude that PLR leads to central volume expansion which causes suppression of sodium retaining factors, and the increase in diuresis and natriuresis not only in healthy objects but also in cirrhotics. This simple method may be used as the first therapeutic regimen in patients with cirrhosis and edemas. (Tab. 2, Fig. 3, Ref. 13.)

Adolescent↗

PubMed2001

Prolactin and interleukin 2 concentrations before and after i.v. TRH application in primary hypothyroidism and in controls.

The authors evaluated serum level of prolactin (PRL) and interleukin 2 (IL-2) before and after i.v. application of tyreoliberin (TRH) 0.2 mg in 10 women as controls and 10 women with primary hypothyreoidism. In controls, there was a significant increase of IL-2 20 min following application of TRH (IL-2 0 min: 17.95 +/- 11.69, IL-2 in 20 min: 33.36 +/- 17.73 fmol/l), in patients with hypothyreoidism the serum level of IL-2 decreased (IL-2 0 min: 31.32 +/- 19.0, IL-2 in 20 min: 19.11 +/- 17.8 fmol/l). The basal concentration of IL-2 in patients with hypothyreoidism was significantly higher as in controls (p < 0.01). The presented finding indicated relation between the neuroendocrine and immune system but its value is not yet apparent. (Tab. 4, Fig. 1, Ref. 7.)

Adult↗

PubMed2000

[Hormonal and morphologic characteristics of adrenal incidentalomas].

The authors analyse hormonal and morphological characteristics of adrenal incidentalomas, i.e. pathological adrenal masses accidentally found on CT scan performed due to extraadrenal causes of other causes of adrenal pathology. The group of patients was consisted by 42 patients at the age 24-79 years (27 females and 15 males). The most frequent clinical symptoms included arterial hypertension, diabetes mellitus and obesity. CT examinations revealed 36 cases of unilateral lesions (in 21 cases the lesions were localised on the right and in 15 cases on the left) and 6 bilateral lesions. The size of adrenal masses ranged from 7 mm to 12 cm. The CT examination helped in characterising myelolipomas in 3 cases, cysts in two cases, and pre-assuming malignity in 6 cases. Hormonal analyses have revealed primary aldosteronism in 2 cases, subclinical hypercortisolism in 1, steroid enzymopathy in 2 and secondary hyperaldosteronism in 2 patients. No patient had catecholamine overproduction. 19 patients were indicated for adrenalectomy with the following histological findings.: adenoma (n = 5), cyst (n = 2), myelolipoma (n = 3), carcinoma (n = 3), feochromocytoma, ganglioneuroma, metastases, lymphoma, sarcoidosis and pseudodrenal structure--Gravitz tumor (n = 1, respectively). The size of all neoplasms exceeded 3 cm, therefore the authors recommend adrenalectomy in incidentalomas with hormonal activity exceeding 3 cm in size. (Tab. 2, Fig. 1, Ref. 17.)

Adrenal Gland Diseases↗

PubMed1999

[Incidence of primary hyperaldosteronism in hospitalized patients with hypertension].

AIMS: To detect the incidence of primary hyperaldosteronism (PH) in hospitalized hypertensive patients. METHODS: Authors assessed plasma renin activity (PRA) and plasma aldosterone (PA) in 100 patients with arterial hypertension hospitalized at the II. department of Internal medicine in Kosice because of resistance to ambulatory treatment, eventually with the aim of differential diagnosis of arterial hypertension. RESULTS: From 100 hypertensive patients 90 (90%) have had essential hypertension (EH), 8 (8%) PH, 2 (2%) renovascular hypertension and 1 patient (1%) pheochromocytoma. Aldosterone-renin ratio was in PH patients 10-fold higher comparing with EH patients. From the 8 patients with PH 4 have had adenoma and in 3 patients hyperplasia was diagnosed with the use of CT or histology, 1 case was idiopathic hyperaldosteronism without CT hyperplasia evidence. In all PH patients the level of kalemia was less than 4 mmol/l, i.e. kalemia 4.0 mmol/l has 100% sensitivity for PH detection. CONCLUSION: Introduction of PRA and PA examinations in the diagnostic process of arterial hypertension led to more frequent diagnosis of PH, which may probably represent the most frequent form of endocrine hypertension. Although ARR is a reliable test for PH screening, routine ARR examinations in ambulatory practice are technically complicated and connected with high costs. Increasing the threshold level of kalemia for PH detection led to higher sensitivity and that is why the authors consider ARR examination rational in every patient with kalemia level less than 4 mmol/l. (Tab. 4, Ref. 18.)

Adult↗