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Biomedical subjects

H Warner

Publications and source records attributed to H Warner.

13 recordsLinked to original sources
PubMed1991

Estimating frequency of disease findings from combined hospital databases: a UMLS project.

Merging data from the Salt Lake VA hospital database and the LDS hospital HELP system into a UMLS sponsored unified patient database has demonstrated that distribution of variables within a disease is hospital independent. Although disease prevalence is clearly not the same among hospitals, analysis of data within a disease group across hospitals can be done using such a merged database. This unified patient database would allow study of unusual diseases not possible using data from a single institution.

Databases, Factual↗
PubMed1991

Iliad training effects: a cognitive model and empirical findings.

Iliad is a diagnostic expert system consisting of an "inference engine" (collection of rules and procedures for making decisions) and a "knowledge base" (collection of medical facts). Iliad's internal medicine knowledge base recognizes 5000 medical findings and covers 1150 diagnostic conditions in 10 subspecialty fields. We used Iliad's simulator mode to train diagnostic skills in junior-year medical students. The results corroborate previous findings documenting Iliad's teaching efficacy. Recent developments in cognitive psychology provide a framework for explaining Iliad's training effects.

Clinical Clerkship↗
PubMed1990

Electroejaculation in spinal cord injury patients: simplified new equipment and technique.

A new simplified electrostimulation system for rectal probe electroejaculation has been developed and tested 17 times in 13 patients. Seminal emissions were obtained easily from 13 of 17 studies and partial emissions were obtained in 4. Patients with cauda equina and conus lesions with partial intact sensorium also could achieve successful ejaculation by longer stimulation from 2 to 5 minutes with lower currents that could be maintained easily and were tolerated by the patient--a feature unique to our new computerized equipment. The simplicity of operation reduces the number of trained personnel for an electrostimulation procedure, which can be done even in an outpatient setting.

Adult↗
PubMed1979

Myocardial infarct imaging with 99mTc-pyrophosphate and 99mTc-methylene diphosphonate: lack of correlation.

A prospective study of eight patients with recent transmural myocardial infarction was performed using 99mTc-Sn-pyrophosphate and 99mTc-Sn-methylene diphosphonate in each patient. All pyrophosphate scans were strongly positive whereas the diphosphonate scan was strongly positive in only one case. We conclude that 99mTc-Sn-pyrophosphate is preferable to 99mTc-Sn-methylene diphosphonate for myocardial imaging.

Diphosphates↗
PubMed1978

Relationship between diazepam dose, plasma level, age, and central nervous system depression.

Patients undergoing elective cardioversion for treatment of arrhythmias were premedicated with diazepam. The dose was individualized to achieve a degree of central nervous system CNS) depression characterized by response to painful but not vocal stimulation. Promptly following each cardioversion, blood was drawn and the plasma diazepam concentration was measured by gas chromatography. The plasma levels varied as widely as the diazepam doses so that there was no fixed plasma level of diazepam associated with the degree of CNS depression produced in these patients. However, both the dose of diazepam and the resulting plasma level were inversely correlated to age, indicating that age is a critical factor in the use of diazepam for cardioversion premedication; elderly are more sensitive to the depressant effects of this drug than the young.

Adult↗
PubMed1978

Rectal probe electroejaculation of primates.

The technique of rectal probe electroejaculation has been developed to permit collection of semen using equipment proven safe, simple, and effective on the 30 primate species so far tested. This paper provides information on the construction and operation of this equipment, together with electrical parameters applicable to primate species. Seminal emission or ejaculation occurs in all species when alternating current is delivered at 0.25 mA/mm2 electrode area. The most effective frequency is 20 Hz, and the most acceptable anesthetic is ketamine hydrochloride.

Animals↗
PubMed1977

The association between basal body temperature, sexual swelling and urinary gonadal hormone levels in the menstrual cycle of the chimpanzee.

Basal body temperature (BBT) was measured continuously by radiotelemetry throughout 14 chimpanzee menstrual cycles and correlated with daily observations of the sexual skin swelling. A biphasic BBT shift from a pre-nadir mean of 36-12 degrees C to a post-nadir mean of 36-67 degrees C was observed in 12 cycles. The temperature nadir showed a close temporal relationship with detumescence of the sexual skin swelling (an early luteal event), but the rate of temperature rise after the nadir was variable. In 3 normal cycles studied, the temperature nadir occurred the day after a urinary oestrone peak, but there was no consistent temporal association between BBT rise and pregnanediol increment. Progesterone secretion is therefore probably not the sole determinant of the BBT shift; the changing oestrogen/progestin ratio may be the more important factor regulating body temperature during the luteal phase.

Animals↗
PubMed1975

Polymorphic acetylation procainamide in man.

N-Acetylprocainamide (NAPA) and procainamide plasma and urine concentrations were determined by thin-layer chromatography (TLC) densitometry in people of known acetylator phenotype (dapsone phenotyping) taking procainamide for more than 3 days. The plasma NAPA/procainamide ratio 3 hr after the last dose for fast acetylators (mean plus or minus SD) is 1.8 plus or minus 0.59 (N equal to 8) and for slow acetylators, 0.61 plus or minus 0.09 (N equal to 6) P smaller than 0.001). The renal clearance of NAPA averaged 1.2 times the simultaneously measured endogenous creatinine clearance, whereas procainamide clearance was approximately double the creatinine clearance. There was no difference between slow and rapid acetylators in the renal clearance of either drug or the urine pH, indicating that the difference in plasma NAPA/procainamide ratios between these two groups is due to differences in their rates of acetylation. Therefore, procainamide is probably acetylated by the polymorphic N-acetyltransferase in man. Reflecting the blood level differences, the NAPA/procainamide ratio in urine (collected 99 to 180 min after last dose) was found to be higher in rapid than in slow acetylators. The plasma protein binding of NAa and of procainamide are similar. Since NAPA seems to have an antiarrhythmic potency similar to procainamide, NAPA probably contributes to the antiarrhythmic activity of procainamide therapy, especially in genetic rapid acetylators.

Acetylation↗
PubMed1975

Cytochemical response of kidney, liver and nervous system of fluoride ions in drinking water.

Morphological and cytochemical studies on the squirrel monkey have been made after maintaining the sujects on pure distilled water and fluoridated distilled water for 18 months with the objective of determining the effect of fluoride on the activity of some hydrolytic and oxidative enzymes in the kidney, liver and nervous system. Daily water intake by individual animals was measured over the final 10 months of the animal's exposure to 0,1 and 5 ppm fluoride. Water consumption was considerably higher in the animals on higher fluoride intake. Whereas the nervous system remained totally unaffected by this experimental procedure, the liver showed a slightly enhanced acivity of Krebs citric acid cycle enzymes. The kidneys, however, showed significant cytochemical changes, especially in the animals on 5 ppm fluoride intake in their drinking water. In these animals, the glomeruli showed an increase in the activity of acid phosphatase and the enzymes belonging to the citric acid cycle and the pentose shunt, whereas lactate dehydrogenase, a resentative of the anaerobic glyoclytic pathway, remained unchanged or only slightly changed. These observations suggest that fluoride in concentrations as low as 5 ppm interferes to some extent with the intracellular metabolism of the excretory system.

Acid Phosphatase↗
PubMed1975

Assessment of ventricular function in coronary artery disease using nitroglycerin and computerized analysis of left ventriculograms.

The ability to predict if abnormalities in regional wall motion are reversible would assist in selecting patients for aortocoronary bypass operation. This study shows that asynergic areas of the ventricle may be reversed by nitroglycerin. Thirty-four asynergic areas in 30 patients with coronary artery disease were studied before and after administration of nitroglycerin. Nineteen patients with previous infarction, diagnostic Q waves in their electrocardiogram, and akinetic areas in the left ventricle had no change in their akinetic areas after nitroglycerin administration. Nine of these patients did show increased motion in other hypokinetic areas of the myocardium. Five of 11 patients with no evidence of previous infarction showed a dramatic improvement in akinetic areas after nitroglycerin, while of the remaining 6, 5 showed mild improvement. This illustrates that recoverable asynergic areas may be recognized by nitroglycerin.

Adult↗
PubMed1975

Conversations with a chimpanzee in a computer-controlled environment.

The linguistic-type skills of a young chimpanzee (Pan) acquired in a computer-controlled language-training situation are reviewed. Those skills include facile acquisition of vocabulary, object naming, color naming, appropriate use of "yes" and "no" in response to certain questions, and conversation. In conversations the subject has formulated novel sentences and without special training has asked that objects be named, whereupon requests were made that they be given to her. These findings are interpreted in terms of how enriched environments can serve to bring forth novel communication skills in the chimpanzee, which is otherwise alinguistic; how the challenge of the environment can serve to limit manifest intelligence; and how a cognitive, rather than the traditional stimulus-response, framework is required for understanding the communication skills and psychological processes of the chimpanzee.

Animals↗