[Cytomorphological studies on spermatogenesis in man].
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Biomedical subjects
Publications and source records attributed to H Wartenberg.
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Some aspects of the development of the human testis (and overy) are discussed and the main theories regarding gonadal differentiation summarized. The major part of this review deals with the origin and differentiation of the three groups of somatic cellular content: Sertoli cells, Leydig cells and peritubular cells. The most important role of the mesonephros in gonadal development is described. Under the influence of the mesonephros, a second type of meiosis-inducing Sertoli cell differentiates and becomes the opponent of a meiosis-preventing type of Sertoli cell which derives from the coelomic epithelium. All somatic cells are pooled in the central gonadal blastema which is part of the medulla. They migrate via the rete blastema to the sites of their final differentiation. Included are the precursors of the Leydig cells and the peritubular cells.
Chicken embryos were treated on day three of incubation with a steroidal or a non-steroidal aromatase inhibitor (1-methyl-androstendion, CGS 16949 A). Complete sex reversal of ovaries into testes or intermediate stages of sex reversal resulted from the inhibitory effect on oestradiol formation during gonadal development before and during sexual differentiation. Germ cell differentiation shifted from the female to the male pattern depending on the local advance of sex reversal.