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Biomedical subjects

H Weidauer

Publications and source records attributed to H Weidauer.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Behavior of the stapedius reflex in long-term acoustic stimulation].

The present examination shows the action of the acoustic reflex on stimulation with a pure tone of 500 cps which lies 10 dB above the reflex threshold by impedance measurement. The duration of stimulation lasts 5 min. The test results of persons with normal hearing, persons with cochlear and retrocochlear lesions were measured according to the amount, the duration, the beginning, and the speed of reflex decay. The preliminary results permit the following conclusions: Persons with noise-induced hearing loss show no reflex decay for the entire duration of stimulation. Persons with normal hearing show a reflex decay after 2 min. After another 135 sec a constant reflex amplitude is attained. Subjects with cochlear lesions which are not caused by noise show similar reflex behavior. The amount of decay is larger, and the decay begins earlier. Persons with retrocochlear lesions show heterogeneous results, but the average amplitudinal decay is rapid and exceeds 50 per cent. The underlying mechanisms are discussed. In our opinion muscle fatigue plays an important role, which is absent in noise-induced hearing loss due to a permanent muscle training caused by the chronic noise exposure. The main result for audiology lies in the possibility to distinguish clearly between noise-induced hearing loss and other forms of cochlear lesions.

Acoustic Impedance Tests↗
PubMed1981

[Results of primary antineoplastic chemotherapy in advanced keratinizing squamous epithelial carcinomas of the head and neck region].

From 1975 to 1980 121 patients with advanced carcinoma of oral cavity, oropharynx and hypopharynx were treated by a primary systemic chemotherapy with vincristine/MTX-folinic acid/intrinsic factor/thymidine--bleomycin/inosine. A complete remission and partial remission of more than 50% was obtained in 81% of tumors of oral cavity, while the remission of the carcinoma of oropharynx with 73% and of hypopharynx with 50% is caused by a lower sensitivity rate of the less keratinizing tumors. The chemotherapeutic results after preceding operation and radiation underline by a lower rate of remissions the only palliative aspect and the necessity of antineoplastic chemotherapy to the first step before operation and radiation. The results of remission followed by primary antineoplastic chemotherapy bring better conditions for the operation and supplementary radiotherapy: the high number of complete remissions allows a tender operation in the field of the former carcinoma with histological security, the partial remission of more than 50% guarantees a more exact determination of the border of tumor and of the distance of security by reduction and demarcation of the tumor, its devitalisation brought by keratinisation, the stop of invasive growth and by the increase of the surrounding connective tissue. Because of the short remission of metastasis of lymph nodes a radical neck dissection and sanitation of the floor of the mouth is an oncological necessity in case of metastasis. The estimated median survival time was 21 months in advanced carcinomata of oral cavity and as for keratinizing squamous cell carcinoma of oropharynx. A lower mean survival period will be expected by the less keratinizing squamous cell carcinomata of the oro- and hypopharynx with 11 or 10 months. Fixed lymph nodes and distant metatasis bring a decrease of the estimated median survival time with a statistical significance.

Adult↗
PubMed1981

[Antineoplastic chemotherapy of head and neck tumors (author's transl)].

The antineoplastic chemotherapy as a treatment of advanced squamous head and neck tumors should be considered as a third fundamental therapy in addition to classical surgery and x-ray techniques. In comparison to other sequences the most favorable results are to be expected when chemotherapy is the first step followed by surgery and radiotherapy. The extend of remission and the median survival time by systemic combined chemotherapy of Methothrexate (MTX), Vincristine and Bleomycin on squamous cell carcinoma of the oral cavity and of the oropharynx seems to be the most acceptable treatment, while i.a. chemotherapy with MTX obviously has a most sufficient effect on hypopharynx carcinoma. A combined cis-platinum therapy or i.a. chemotherapy of MTX and Bleomycin or the combination of Vincristine, Bleomycin and low dose MTX underline good single results but the small collectives and short-term follow up do not allow any statement up to now.

Adult↗
PubMed1981

[Prosthetic replacement of the trachea by synthetics (author's transl)].

Long tracheostenosis especially when sharing the mediastinum should be treated by a team of ENT- and thoracic surgeons. In 14 cases we achieved good functional results by transverse resection and anastomosis of the trachea. Plastic surgery of the trachea is limited by the etiology and the length of the shared tracheo-bronchial area. Neville (1976) has experiences in prosthetic replacement by synthetics in 26 cases. In 4 cases of special and cautiously placed indication we used Neville-prosthesis. The indications, the problems and the results are reported.

Humans↗
PubMed1981

[A contribution to Tornwaldt's disease (author's transl)].

The signs of Tornwaldt's disease, such as postnasal discharge, increase of mucous secretion, dysfunction of the eustachian tube, sometimes associated with middle-ear infection, are now rarely seen in comparison to the 19th century. In this article, we report about a sign of Tornwaldt's disease which had not been described up to now: A troublesome expiratory whistle. The resection of the bursal wall eliminated this sign. The short-term whistle as the only sign of Tornwaldt's disease, without histological signs of inflammation, underlines Tornwaldt's idea that inflammation is a secondary reaction of nasopharyngeal cysts.

Adult↗
PubMed1980

[Tracheal stenosis and keloid disposition (author's transl)].

Patients with disposition for cicatricial keloid are expected to get tracheal stenosis by long time intubation. Latest after 48 hours the respiration done by respirator should be managed by tracheotomy tube. Instead of classic tracheotomy an epitheliced tracheotomy should be preferred. For the therapy of tracheal stenosis--excision of tracheal stenosis and end to end anastomosis as well as tracheal groove by Rethi with transplantation of mucosa--the application of triaminolonacetonoid has proved to avoid restenosis by secondary keloid.

Adolescent↗
PubMed1976

[Experimental demonstration of an identic antigenicity of the inner ear and kidney (author's transl)].

An allergic glomerunephritis was produced in rats by injection of an anti-basement-membrane-serum (IgG-fraction), taken from rabbits which were sensitized against a basement membrane fraction of rat-glomerula. Tissues from heart, liver, brain, lung and inner ear were compared with the well known alterations of the glomerula. Exclusively in stria vascularis and renal glomerula heavy changements of the basement membranes and endothelial cells could be shown by electronmicroscopic examination and by immunohistological methods.

Animals↗
PubMed1976

[Morphological changes in the inner ear of alport's syndrome (author's transl)].

At the first time lightmicroscopic and electronmicroscopic findings of Alport's Syndrome after fixation 1 hour post mortem are demonstrated. The morphological findings of stria vascularis, organ of Corti and ganglion spirale are discussed and interpreted as the result of the enlarged basal membrane of the inner ear capillaries with an altered permeability similar to the thickened basal membrane in the glomerulum of Alport's Syndrome.

Adult↗