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Biomedical subjects

H Weitz

Publications and source records attributed to H Weitz.

At least 19 recordsLinked to original sources
PubMed2002

A novel reconstruction technique for chronic lateral ankle instability: comparison to primary repair.

Twenty patients with lateral ankle instability were treated by a novel anatomical reconstruction technique (group A) and the results compared with 20 patients (group B) who, during the same period of time, underwent primary repair of ruptured lateral ligaments of the ankle. We reviewed 15 patients from group A and 17 patients from group B at a mean follow-up of between 2 and 4 years. The mean functional scores were good in both groups without significant difference, and there was no difference in the mean anterior talar translation between the two groups. We therefore conclude that chronic lateral instability of the ankle may be successfully treated, even in the presence of severely damaged, attenuated or absent ligament tissue.

Adolescent↗
PubMed1989

Spatial and temporal variability of blood flow in stimulated dog gastrocnemius muscle.

The distribution of blood flow in skeletal muscle stimulated to rhythmic isotonic contractions was studied by injections of radioactive microspheres into the arterial supply of gastrocnemius muscles (mean weight 88 g) subsequently cut into 0.5 g pieces for determination of radioactivity. The coefficient of variation (CV = SD/mean) of the ratio of simultaneously injected 10 microns and 15 microns microspheres, 0.12, was taken as the inherent scatter of the method. The average spatial distribution inequality of 10-15 microns microspheres corresponded to a CV of 0.45 and the specific local blood flow inhomogeneity to a CV = 0.43 (= square root of 0.45(2) - 0.12(2)), but there were marked differences between muscles. The temporal variability of blood flow in individual muscle pieces was obtained from the comparison of fractional trapping of 4 to 5 differently labeled microspheres injected at intervals of 2 minutes into steadily stimulated muscles. The mean CV for the variations in time was 0.23 and that corrected for methodological scatter, 0.19. There were large differences between muscle pieces within a muscle and between muscles. The presence of considerable spatial and temporal variations of blood flow in exercising muscle during apparent steady state may be important in limiting and/or modulating tissue O2 supply.

Animals↗
PubMed1988

Blood flow distribution and its temporal variability in stimulated dog gastrocnemius muscle.

The distribution of blood flow in skeletal muscle stimulated to rhythmic isotonic contractions was studied by injections of radioactive microspheres into the arterial supply in 8 gastrocnemius muscles (mean weight 84 g) of 6 anesthetized dogs (20-25 kg body weight). The distribution of 10 micron microspheres in regions of about 0.5 g was very similar to that of the standard 15 micron microspheres, whereas that of 25 micron microspheres was more uneven. The coefficient of variation (CV = SD/mean) of the ratio of simultaneously injected 10 micron and 15 micron microspheres, 0.12, was taken as the inherent scatter of the method. The average spatial distribution inequality of 10-15 micron microspheres corresponded to a CV of 0.45 and the specific local blood flow inhomogeneity to a CV = 0.43 ( = square root 0.45(2) - 0.12(2], but there were marked differences between muscles. At equal blood flow levels, the inhomogeneity during reactive hyperemia was similar to that observed during stimulation. The temporal variability of blood flow in individual muscle pieces was obtained from the comparison of fractional trapping of 4 to 5 differently labeled microspheres injected at intervals of 2 min into steadily stimulated muscles. The mean CV for the variations in time was 0.23 and that corrected for methodological scatter, 0.19, but the differences in the extent of temporal blood flow changes among muscle pieces within a muscle and between different muscles were large. The presence of considerable spatial and temporal variations of blood flow in exercising muscle during apparent steady state may be important in limiting and/or modulating tissue O2 supply.

Animals↗
PubMed1986

Cardiac dysrhythmias associated with ophthalmic atropine.

Atropine sulfate, a mydriatic and cycloplegic agent, is frequently used in patients undergoing glaucoma surgery. Trabeculectomy with peripheral iridectomy is the most common glaucoma surgery performed to decrease intraocular pressure and preserve vision. Systemic absorption of ophthalmic atropine does occur and may result in toxic and adverse side effects. Cardiac dysrhythmias are one of the major adverse reactions. This case study reviews three patients who had a trabeculectomy for glaucoma and received ophthalmic atropine. One patient received both systemic and ocular atropine. Two patients developed atrial fibrillation and one a supraventricular tachycardia. Two patients required admission to a cardiac intensive care unit for management of the dysrhythmia and a third reverted to normal sinus rhythm spontaneously. The cardiac effects of ophthalmic atropine should be considered in the preoperative and postoperative assessment of patients with dysrhythmias.

Absorption↗
PubMed1984

The effect of cholecystectomy on the induction of colorectal tumors in mice by 1,2-dimethylhydrazine.

The influence of previous cholecystectomy (CCE) on the 1,2-dimethylhydrazine (DMH)-induced colorectal tumorigenesis was examined in 497 female NMRI mice after 14, 20, 24, 28, 33, and 36 weeks of induction time. There were only minor differences between the cholecystectomized and the non-cholecystectomized animals with regard to the percentage of tumor-bearing animals, number of adenomas, and location of the tumors. Only after an induction time of 20 weeks, the operated group had significantly more carcinoma-bearing animals than the non-operated group (P less than 0.01, chi 2-test). The implication of these results on known data of epidemiologic studies in human colorectal cancer are discussed.

1,2-Dimethylhydrazine↗
PubMed1983

[Cholecystectomy, cholelithiasis and cancer of the large intestine].

In a retrospective post-mortem study the connection between the post-cholecystectomy state, cholelithiasis and carcinoma of the large intestine was evaluated in 333 cases and compared with an age and sex matched control group and a group with gastric carcinoma. It was established that cholelithiasis (without cholecystectomy or contracted gallbladder) occurred significantly more frequently (24.9%) in patients with colonic carcinoma than in the control group (15.3%) or the gastric carcinoma group (12.6%) (P less than 0.001). In contrast the rate of cholecystectomy in patients with colonic carcinoma was not significantly increased (6.3%) when compared with both control groups (4.6 and 4.8%). Separate assessment of males and females showed that females had cholecystectomy and contracted gallbladder significantly more frequently (P less than 0.05). These figures suggest that the clinically observed association between cholecystectomy and colonic carcinoma reflects only a - not necessarily causative - connection between gallstone disease and colonic carcinoma.

Aged↗
PubMed1983

Radiographic instability of the ankle joint after Evans' repair.

Forty-two unstable ankle joints were treated surgically by Evans' operation. The clinical postoperative results were correlated with the objective radiological stress examinations. The mean age of the patients was 29 years (15-60 years). The clinical and radiological follow-up examinations were performed 6 months after the operation. In the stress X-ray examinations a modified stress frame was used. Clinical instability was noted in four patients. In the radiological examination one patient had a pathological finding in the talar tilt test and 18 patients in the anterior drawer sign test. The radiological instability correlated poorly with the subjective end results. Six patients were estimated to have a poor result of the operation. Five of these patients had a positive anterior drawer sign in the stress X-ray examination and one had degenerative changes in the ankle. Although Evans' repair is a simple and reliable method of reconstructing ruptures of the lateral ligaments of the ankle joint, it is associated with a relatively high frequency of positive anterior subluxation on radiological stress examination. This finding can be explained by the anatomical and geometrical factors on the lateral side of the ankle joint.

Adolescent↗
PubMed1982

Cutaneous immunoblastic T-cell lymphoma.

The case of a 69-year-old male patient with an unusual type of malignant lymphoma is presented. Clinically, it was at first characterized by follicular papules and erythematous patches, later, by the development of cutaneous tumors and enlarged lymph nodes, and by a severe, finally excruciating pruritus. Treatment with PUVA (psoralen-ultraviolet-A) combined with 40--80 mg prednisolone and then with chemotherapy [COPP regimen (cyclophosphamide, vincristine, procarbacine, prednisone), high-dosage methotrexate followed by citrovorum factor rescue] was not successful. The patient died of pneumonia 2.5 years after the onset of the first clinical symptoms. An immunoblastic infiltrate was observed histologically and electromicroscopically in the initial lesions of the skin. Therefore, the diagnosis of a cutaneous immunoblastic T-cell lymphoma was tentatively made at the beginning, which was later confirmed in numerous biopsies and laboratory investigations. Immunocytologically and enzymecytochemically, the infiltrating cells were shown to be immature T cells; in the lymph nodes, numerous immunoblasts and large Sézary cells was observed in the peripheral blood, though there were no very large Sézary cells or blast cells. In the autopsy, a systemic involvement with an atypical lymphoid infiltration was found in numerous internal organs. The special nature of this case justifies its classification as high-grade malignant lymphoma and its differentiation from normal cases of mycosis fungoides. In contrast, mycosis fungoides generally fulfils criteria typical of low-grade malignant lymphomas.

Aged↗
PubMed1980

[Malignant hyperthermia. A case report (author's transl)].

An exceptionally serious case of malignant hyperthermia in a 17 year old male is presented. A detailed description of the case is given concerning symptomatology, course, laboratory data and morphologic alterations. Our patient died after 7 weeks of intensive care due to therapy resistant septicemia and coagulation disorder. Intense adynamia and advanced muscular atrophy were present. Necropsy showed regionally different extensive lysis of skeletal muscles. In the discussion the advantage of an "ice gravel" producing machine in cooling measures, the necessity of higher procaine doses and problems of long term therapy in trauma patients coincidentally affected with malignant hyperthermia, are stressed.

Adolescent↗
PubMed1979

[Osteochondritis dissecans of the patella (author's transl)].

Five cases of osteochondritis dissecans patellae were seen and followed during years 1971--1978. Special interest was pointed to the site of the lesion, at which age the disease appeared, and to the physical activity of the patients. In one case only patellar subluxation could be confirmed. In two cases radioisotope (Tc99) szintigraphy was done with positive finding. The radiological finding was typical in all cases. The treatment was conservative in all cases but one. Loose body formed once in the series. Operative treatment should be directed only to the cases with persistent symptoms and/or loose bodies.

Adolescent↗