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Biomedical subjects

H Westling

Publications and source records attributed to H Westling.

At least 19 recordsLinked to original sources
PubMed1993

Lund University and its neurobiological traditions.

Lund University was founded in 1666 as part of a strategy to assimilate the province of Scania in southern Sweden, which had been obtained from Denmark after a war ending in 1658. The present main building was erected in 1882. The University Hospital and the medical departments are located in the campus area northeast of the building. The main strength of the medical faculty lies in the neuro-biosciences. In retrospect, they offer a fascinating development with interesting historical connections as well as present-day contracts between many scientific disciplines. This shows once again that real scientific progress requires the interaction of many brains; in other words, the cross-fertilization offered by a critically large mass of scientists from different fields working relatively close together over long periods of time.

History, 17th Century↗
PubMed1989

Fluorescein angiography and distal arterial pressure in patients with arterial disease of the legs.

Fluorescein angiography (FA) of the foot soles was performed in 119 patients with arterial disease of the legs. Fluorescein was injected rapidly intravenously and sequential photographs were taken of the foot soles. Densitometric measurements were performed on three areas of each foot image: the big toe, the foot pad (just proximal to the little toe) and the heel. The relationships between different FA measurements and systolic arterial pressure in the ankle or the big toe were analysed. The appearance times of fluorescence correlated inversely with ankle pressure (P less than 0.001). The initial slopes of the fluorescence-time curves at all three sites of measurement correlated with ankle pressure (P less than 0.001). The initial slopes of fluorescence-time curves of the big toe and the foot pad correlated with toe pressure (P less than 0.001). In 12 patients effective arterial pressure was lowered by elevation of the feet, and in eight patients external pressure was applied to the foot by enclosing it in a box. The changes in FA evoked by these manoeuvres further strengthened the relationship between arterial pressures and FA measurements. We conclude that FA is a good method for evaluating circulation in the foot when neither ankle nor toe pressure is obtainable. In addition, FA may be useful when vascular disease is suspected in the presence of normal pressures, because the fluorescence distribution pattern was clearly abnormal in 11 of 16 such feet.

Adult↗
PubMed1989

Effect of the calcium antagonists felodipine and nimodipine on cortical blood flow in the spontaneously hypertensive rat.

We studied the effect of the dihydropyridine calcium antagonists felodipine nimodipine on perfusion of the cerebral cortex in the spontaneously hypertensive rat (SHR). Nimodipine and felodipine were infused in equipotent doses in chloralose-anaesthetized SHR. During the infusion of a low and an intermediate dose of felodipine, mean arterial blood pressure was lowered to 90.5 +/- 1.5 and 67.1 +/- 2.9% of the control level. The nimodipine infusion lowered mean arterial pressure to 85.7 +/- 2.0 and 59.7 +/- 2.4% of the control level. At these pressures, cortical perfusion as measured by a laser Doppler flow technique increased to 123.5 +/- 6.9 and 130 +/- 5.4% of the control level during the felodipine infusion and to 114.0 +/- 1.6 and 122.3 +/- 3.2% of the control level during the nimodipine infusion. When these results were compared by covariance analysis of variance, felodipine induced a significantly greater change in cortical perfusion. At the highest dose of felodipine and nimodipine there was no significant difference in cortical perfusion between the two drugs. The administration of felodipine induced a decrease in cerebrovascular autoregulation. However, this impairment of cerebrovascular autoregulation is not likely to trigger cerebral hypoperfusion. Thus, for a mean arterial pressure of 55 mmHg, the laser Doppler-measured cortical flow was, if anything, elevated after felodipine administration.

Animals↗
PubMed1986

Nitroglycerin and arterial compliance.

The primary effect of nitrates on the circulatory system is a relaxation of capacitance vessels on the venous and arterial side, while dilatation of resistance vessels (arterioles) is a secondary phenomenon, or occurs only at higher doses. Relaxation of arteries may augment flow in conditions where these vessels offer an increased resistance due to e.g. spasm. Relaxation of capacitance arteries explains in part the lower systolic blood pressure after nitroglycerin. Improved "Windkessel" function may augment diastolic arterial pressure and thus improve coronary perfusion. Some methods for measuring arterial compliance are described. It is suggested that more simple measurements of arterial pulsations may be used for studying nitroglycerin tolerance.

Arteries↗
PubMed1984

Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine.

Pulsatile changes in the volume of an arm segment were recorded with an air-filled plethysmograph and related to intra-arterial blood pressure. Alterations in transmural arterial pressure were obtained by changing the pressure in a large chamber surrounding the entire arm. Arterial compliance values were calculated in late diastole when pressure and volume changes were slow. Compliance varied with transmural arterial pressure in a hyperbolic manner, rising steeply at low pressure. Noradrenaline and hypertensin did not change the arterial compliance values, while dihydroergotamine reduced them. Nitroglycerine caused a pronounced increase in compliance values in doses that did not change cardiac output and arterial pressure.

Adult↗
PubMed1984

Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma.

In regional hyperthermic perfusion with melphalan for patients with malignant melanoma of the leg, plasma leakage between the perfusion circuit and the systemic circulation was 4-7 ml X min-1. The melphalan concentration in the perfusate was biphasic, with half-lives of 8-12 mins for the initial phase and 19-28 mins for the second phase, after the first dose. After a second dose, the corresponding values were 11-13 and 26-34 mins. The highest concentration in general circulation was 0.38 micrograms X ml-1.

Chemotherapy, Cancer, Regional Perfusion↗
PubMed1983

Thermography in the diagnosis of deep venous thrombosis. A comparison with 99Tcm-plasmin test, clinical diagnosis and phlebography.

Thermography, clinical examination and 99Tcm-plasmin test were performed in 112 patients and compared with phlebography. The study population consists of consecutive outpatients with symptoms compatible with deep venous thrombosis, who presented during regular clinic hours. Scoring systems were constructed for the clinical and thermographic evaluation. Both thermography and clinical diagnosis were insufficiently sensitive and specific for screening purposes. Plasmin test had a high sensitivity, 95%, but a low specificity. It is possible that a combination of thermography and clinical diagnostic criteria can provide an acceptable screening procedure. Combining thermography with a routine examination by the physician on duty yielded less favourable results.

False Negative Reactions↗
PubMed1983

Double blind comparison between iohexol and metrizoate in phlebography of the lower limb.

A new, non-ionic low osmolar contrast medium, iohexol 240 mg I/ml, has been tested in a randomized double blind parallel investigation versus meglumine-Ca metrizoate 200 mg I/ml. The study was performed to evaluate the suitability of the contrast medium in phlebography. No post-phlebographic complications were seen in the 24 patients examined with iohexol 240 mg I/ml or in 8 patients examined with iohexol 300 mg I/ml. In the 19 patients examined with metrizoate 200 mg I/ml, 7 had a post-phlebographic thrombotic complication (37%). The radiographic image quality was not significantly different between the two contrast media, neither were the immediate side effects during contrast injections. It has thus been shown that iohexol is a suitable contrast medium in phlebography of the lower limb and that it is preferable to conventional contrast media.

Adult↗