Antibacterial Concentrations in Serum and Dental Tissues after Preoperative Application of Propicillin. After resecting radicular and follicular cysts in the jaws, the serum, bone, capsule and fluid of the cysts from 40 patients were studied for their propicillin concentration. The patients received 1 Mega unit (0.7 g) propicillin orally as oblong tablets one or two hours before surgery. One or two hours after the application of propicillin, the distribution coefficients between serum and the three tissues were 0.78 and 0.87 for the spongious bone, 0.07 and 0.06 for the cyst capsule and 0.14 and 0.08 for the cyst fluid. The mean concentrations in all three tissues were distinctly above the MICs of the bacteria most frequently isolated from the mouth for at least two hours.

Administration, Oral↗

PubMedDate not supplied

Ciprofloxacin concentrations in tonsils following a single intravenous infusion.

Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindividual ratios between tonsil and serum concentrations 100% to 288%). Ciprofloxacin distribution was homogeneous and independent of sampling time.

Adult↗