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H Wilbur

Publications and source records attributed to H Wilbur.

4 recordsLinked to original sources
PubMed1999

Encephalopathy after bladder irrigation with alum: case report and literature review.

A 70-year-old man with advanced obstructive nephropathy began to hemorrhage from the bladder after decompression with a Foley catheter. Manifestations of encephalopathy appeared after continuous irrigation with 1% alum for 2 days and were associated with elevated serum aluminum concentrations. Repeated treatments with deferoxamine and hemodialysis accomplished some aluminum removal, but the patient succumbed to bronchopneumonia. Brain aluminum content was not excessive at autopsy. A literature review suggests that intact renal function is essential to rapid disposal of a parenteral aluminum load and indicates that most reported instances of encephalopathy after alum irrigation have occurred in patients with compromised renal function. We conclude that alum should not be employed as a bladder irrigant in patients with acute or chronic renal failure.

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PubMed1983

Moxalactam concentrations in human prostatic tissue.

The concentrations of moxalactam in human prostatic tissue, obtained by enucleation or transurethral resection, were measured in 10 patients after the intramuscular administration of two 500-mg doses. The average concentrations of moxalactam in prostatic tissue in the enucleated and transurethral resection specimens were 4.0 micrograms/g and 5.2 micrograms/ml, and the ratios of the moxalactam concentrations in prostate to those in plasma were 0.24 and 0.31, respectively. The concentrations of moxalactam achieved in prostatic tissue after the administration of relatively low doses were greater than the minimum inhibitory concentrations of moxalactam for most common gram-negative pathogens. Concentrations of moxalactam in carefully obtained transurethral resection specimens were similar to those found in the enucleated specimens.

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PubMed1981

Prostatectomy in patient with leukemia.

We have reviewed our experience with 10 patients who had leukemia and prostatic obstruction. Most of these patients had chronic lymphocytic leukemia, and all were stable. Following routine preoperative evaluation all underwent transurethral resection of the prostate (TURP). Two patients (20 per cent) had leukemic infiltration of the prostate. Our series confirms that TURP does not present undue risk to the patient with leukemia if the disease is stable and preoperative evaluation normal.

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