The case report of a female child born preterm (30th wk of gestation) who developed symptoms of Cushing's syndrome beginning in the neonatal phase is presented. The disease was caused by a unilateral adreno-cortical nodular hyperplasia and was successfully treated by unilateral adrenalectomy. Preoperative treatment with ketoconazole and metyrapone proved to be effective. Symptoms of Cushing's disease including hypertrophic cardiomyopathy were completely reversible within one month after surgery.

Adrenal Hyperplasia, Congenital↗

PubMedDate not supplied

Testosterone, estradiol, ACTH and musical, spatial and verbal performance.

Testosterone, estradiol, and ACTH were determined in blood serum of 26 healthy males aged 19.16 and of 25 healthy females aged 18.77 years on average, and results were correlated with test scores of three spatial tests, a verbal fluency measure, and a test measuring general musical ability. In addition, hemispheric lateralization for verbal material and handedness was assessed. While testosterone and estradiol alone were not significantly related to any of the cognitive or musical tests, testosterone/estradiol ratio was significantly negatively correlated with spatial tests, and ACTH was significantly positively correlated with spatial and musical tests. Correlations were stronger in females than in males. The laterality index was significantly negatively correlated with testosterone in males indicating that right hemisphere involvement in verbal processing was associated with high testosterone levels.

Adolescent↗

PubMedDate not supplied

[Iodine concentration in the breast milk of mothers of premature infants].

UNLABELLED: In this prospective study the longitudinal iodine concentration was compared in breast milk of preterm infants mothers, with and without iodine supplementation. 195 samples of breast milk from 60 mothers were analyzed by HPLC longitudinally. RESULTS: Mothers who take additional iodine (200 micrograms/d) had significant higher mean iodine concentrations in breast milk (mean: 7.6 +/- 6.3 micrograms/dl) than mothers without additional iodine supply (mean: 5.5 +/- 5.8 micrograms/dl/p < 0.02). Nontreated mothers showed significantly more breast milk iodine concentrations below the recommended minimum concentration of 5 micrograms/dl (64%, n = 84) than treated mothers (40%, n = 25/p = 0.0016). Mean iodine intake in preterm infants of treated mothers was higher (11.9 micrograms l/kg) than in preterm infants of nontreated mothers (7.9 micrograms l/kg). DISCUSSION: The measured iodine concentrations in breast milk of preterm infants mothers markedly varied inter- and intraindividual. The variations might be explained by irregular daily iodine intake and a dilution effect by increasing breast milk volumes. CONCLUSIONS: Iodine supplementation of lactating mothers leads to elevated iodine content of their breast milk. The recommended intake of iodine for both newborns (15 micrograms l/kg) and preterm infants (30 micrograms l/kg) was not reached in the breast fed preterm infants in both groups of our study.

Adult↗

PubMedDate not supplied

[Determination of polarity of drugs. 14. Contributions to problems of use of plastic containers for liquid drug preparations].

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Chemical Phenomena↗