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Biomedical subjects

H Wuthe

Publications and source records attributed to H Wuthe.

At least 19 recordsLinked to original sources
PubMed1985

[Prognosis and indications of corticosteroid treatment of intrathoracic sarcoidosis--conclusions from a prospective study].

Preliminary results of a prospective clinical trial to evaluate the value of corticosteroid therapy of intrathoracic sarcoidosis had demonstrated that there were no differences between treated and untreated patients with regard to the clinical, radiological and functional outcome after several years. In one hundred and seventy two patients we could check the former results by identical tests after a longer follow-up period (mean 8,9 years) and by additional physiological assessments, i.e. Cstat, DLCO, DM, VC, which seem to be more significant for early detection of functional disorders in sarcoidosis. Again the findings showed no significant differences neither between patients treated with prednisolone for 12 or 6 months respectively nor when compared to the untreated group. In conclusion we do not treat patients with asymptomatic intrathoracic sarcoidosis and without extrapulmonary manifestations before the disease shows no regressive course within one year or when a progressive course is observed.

Adult↗
PubMed1985

[Factors influencing the diagnosis of lung function and our current reference values--results of the Pathophysiology of Respiration Society].

Reference values for lung function testing were determined of the spirometric volume and ventilation parameters VC, FEV1, RV (n = 3,750), bodyplethysmographic airway resistance and residual volume blood gases in rest (n = 5,779) and exercise (n = 117) considering the main influencing factors age, height, sex. The results were compared with international standards. Eleven laboratories of our country were engaged in examinations. The methods, the measuring conditions, the reference equations, and the valuation are described.

Adult↗
PubMed1984

[Lung function disorders in obesity].

For the pulmonary assessment of obesity or lung diseases in extremely obese persons the pathophysiological alterations and their consequences for assessment of pulmonary function are described. The review includes also own results.

Carbon Dioxide↗
PubMed1984

[Implementation and evaluation of the inhalation antigen test in the diagnosis of exogenous allergic alveolitis].

By the aid of antigen inhalation challenge test 16 patients with precipitating antibodies to bird antigens (pigeons, hens, budgerigars) and the supposed diagnosis of extrinsic allergic alveolitis (EAA) were examined. Criterions for the evaluation of the objective parameters (FEV1, FVC, Ros, body-temperature, number of leukocytes) were established. The combination of objective parameters and subjective symptoms leads to the evaluation of the challenge test. Different types of bronchial response (monophasic and dual-responses) were observed after inhalation of antigens. In 7 cases the diagnosis of EAA was proved to be true according to the challenge test results. If there are no typical alterations in chest-x-rays and no alterations of ventilatory function, the antigen inhalation challenge test is the method of choice in the diagnosis of EAA.

Adolescent↗
PubMed1984

[Experiences with oscilloresistometry in addition to spirometry in preoperative function diagnosis in the elderly].

A sample of 57 geriatric surgical patients were investigated with the aim of establishing which additional information the forced oscillation method yields for the assessment of an increased operation risk as compared with spirometry. In addition to the proved diagnosis of a restrictive ventilatory disturbance as causing a limitation of the maximum available respiratory volume, the measuring of the oscillatory resistance makes it possible in particular to prove and quantify the obstruction. Over and above this, the measuring of resistance fluctuation while breathing at rest makes it possible to differentiate a geronto-typical exobronchial component of the obstruction. Conclusions are drawn for the improved care of geriatric surgical patients.

Adenoma↗
PubMed1984

[Value of spirometric, pneumotachographic and oscilloresistometric studies in the functional diagnosis of obstructive respiratory tract diseases].

Tests were conducted on 90 smokers and a control group of 20 non-smokers using not only simple spirometry but also pneumotachography and the forced oscillation technique, including flow- and resistance-volume graphs. FEV1 was proved to be a sensitive screening test for early recognition of disfunction in the region of the small airways. 39,5% of the younger light smokers already showed signs of impairment to the breathing mechanics indicating exobronchial obstruction. The heavy, mostly older, smokers frequently showed complex disfunction, and in 55,3% the oscillatory resistance revealed quantifiable endobronchial obstruction. The oscillatory flow-resistance-increase-volume (as a percentage of vital capacity) proved the most sensitive small-airways-test during middle age, permitting significant distinction of smokers from non-smokers up to the age of 55.

Adult↗
PubMed1981

[Discriminating power of multivariate parameters of respiration in epidemiological studies (author's transl)].

Applying a broad scale of lung function tests in epidemiological surveys (929 metal workers of a big industrial shop, 211 of them with signs of chronic obstructive lung disease, COLD, and 1,266 pupils of 2 towns with different dust exposition) we found similar multivariate discriminant functions in all age groups between 7 and 79 years of age to differentiate between COLD-population and normal population. Residual volume in % of total capacity (RV/TC) seems to be the most relevant central parameter in all age groups, which should be combined with one of the inhomogeneity parameters of single breath or multi breath distribution tests ( delta F/ delta V or breath of inhomogeneity IHB) in juveniles between 7 to 16 years of age and with closing volume (CV/VC) in adults between 20 to 79 years of age. Conventional ventilation parameters and the arterial oxygen tension don't contribute additional information to multivariate analysis, which isn't already summarized by the parameters RV/TC.

Adolescent↗
PubMed1981

[Airway-resistance in pregnancy measured by oscillation-technique (author's transl)].

Measurements of resistance were performed in 430 healthy pregnant women, 30 non-pregnant women and 33 puerperae by employing the oscillation-technique. The patients were studied in sitting and standing positions. It was found, that 2 maxima of resistance exist in pregnancy: the first in the 6th, the second in the 9th month. In the sitting position the resistance was higher than in the standing one.

Airway Resistance↗
PubMed1981

[A contribution to bullous emphysema].

Bullous pulmonary emphysema is a disease predominantly occurring uni- or bilaterally in men. While smaller localized bullae in the apex of the upper lobes may be the cause of spontaneous pneumothorax in younger asthenic patients, it may be the cause of fatal situations in older patients by rupture of giant bullae. False diagnosis between partial spontaneous pneumothorax and bullous emphysema are common, even now. The therapy of choice in all patients with bullous emphysema and still sufficient pulmonary function is surgical treatment with taking away the bullae. Only in patients older than 70 years with cardiorespiratory failure a longer lasting drainage therapy seems to be indicated. The results of all cases with bullous emphysema (47) treated in the thoracicosurgical department of the Research Institute for Pulmonary Diseases and Tuberculosis within 27 years are reported.

Adult↗
PubMed1980

Site and type of impaired lung function in extrinsic allergic alveolitis.

We investigated 109 persons exposed and sensitized against organic antigens. 46 of them (group I) are affected with the typical clinical and roentgenological signs of allergic alveolitis. The other 59 subjects (group II) were sensitized only. Included in all examinations were immunological diagnosis by means of counterimmunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms. Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body plethysmography, esophageal balloon technique), respiratory mechanics of the small airways (closing volume, amplitude of cardiogenic oscillations), distributional analysis, diffusion analysis, blood gas analysis, and right heart catheterization. Extrinsic allergic alveolitis caused changes in lung mechanics, in airways as well as in lung tissue. The most impressive findings in allergic alveolitis are mechanical inequalities of ventilation. These inequalities may be caused by changed mechanics of overall airways indicated by obstruction parameters and by changed structure of lung tissue reflected in decreased compliance, transfer factors and increased pulmonary arterial pressure. Not only a restrictive but also an obstructive disturbance of ventilation is found. Impairments are less in sensitized persons. We find slight mechanical and ventilatory inhomogeneities. An overall airway obstruction is obvious but not to such a large extent as in allergic alveolitis. On the contrary, here the lung tissue is not affected. Compliance and diffusion are within the normal range. There is no typical functional pattern specific for the diagnosis of allergic alveolitis.

Adult↗