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H Y Yao

Publications and source records attributed to H Y Yao.

4 recordsLinked to original sources
PubMed1991

[Studies on antidepressant effects of several overshort peptides (OSP)].

The antidepressant effects of 5 OSP (TRH, KTP, CHP, gamma DGG, and AGF) were studied with two behavior despair models in mice. Only CHP was shown to decrease the spontaneous motor activity of mice, the others almost showed no effect in open field test. TRH significantly shortened the immobility produced by tail suspension test and the persistent immobility produced by cornea electrostimulation test. This indicates that the antidepressant characteristic of TRH is very similar to amitriptyline or that amitriptyline exerts its antidepressant effect by affecting TRH in CNS.

Amitriptyline↗
PubMed1990

Involvement of amygdala pathways in the influence of post-training intra-amygdala norepinephrine and peripheral epinephrine on memory storage.

These experiments examined the role of two major amygdala afferent-efferent pathways--the stria terminalis (ST) and the ventral amygdalofugal pathway (VAF)--in mediating the effects, on memory storage, of post-training intra-amygdala injections of norepinephrine (NE) and subcutaneous (s.c.) injections of epinephrine (E). Rats with either ST lesions or VAF transections and sham-operated rats were trained on a one-trial step-through inhibitory avoidance task and immediately after training received intra-amygdala injections of NE or a buffer solution. Other groups of VAF-transected animals received post-training s.c. injections of E or saline. ST lesions blocked the memory-enhancing effect of intra-amygdala injections of a low dose of NE (0.2 microgram) as well as the amnestic effect of a high dose of NE (5.0 microgram). In contrast, VAF transections did not block the memory-enhancing effect of NE (0.2 microgram). However, VAF transections attenuated the memory-enhancing effect of s.c. injections of E: the effective dose of E was shifted from 0.1 to 0.5 mg/kg. These findings, considered together with previous evidence that ST lesions block the memory-enhancing effect of peripheral E injections, suggest that the VAF is involved in mediating the central influence of peripheral E on amygdala functioning, while the ST is involved in mediating amygdala influences on memory storage elsewhere in the brain.

Amygdala↗