PubMed Health⌕ Search

Biomedical subjects

H Yama

Publications and source records attributed to H Yama.

4 recordsLinked to original sources
PubMed1979

[Clinico-antimicrobial evaluation of cefuroxime by observation of transitional change of micro-organisms in urine specimen (author's transl)].

Cefuroxime (CXM) was administered for 1 week to spinal cord injury patients with chronic complicated urinary tract infection and the transitional change of micro-organisms was observed. Bacterial counts and identification of isolated organisms were performed daily on the mid-stream urine for 1 week. MIC was also determined on the strains before and after CXM treatment. The results with 83 strains from 28 patients are as follows: 1. CXM's efficacy appears in line with MIC of strains. With the cases given 0.75 g twice daily intramuscularly, all the 14 strains with MIC lower than 50 micrograms/ml were eradicated, but 2 of the 14 strains were found re-growing, with only bacteriostatic action noted (in region of minimal inhibitory action). With the group of the cases given 1.5 g twice daily, all the 15 strains with MIC lower than 200 micrograms/ml were eradicated from urine 1 approximately 3 days after start of treatment (in region of bactericidal action). 2. At dose of bactericidal action CXM responded effectively with no relationship to organism species or bacterial count before CXM treatment. 3. Dose response was noted between the cases given 1.5 g daily and those given 3.0 g daily. 4. From the above result, we can presume appropriate doses in accordance with the disease conditions. From above observation, combined with correlation between organism species, bacterial count, MIC of strains, etc., CXM's efficacy was assessed quantitatively and objectively.

Bacteria↗
PubMed1976

[Experimental study on aldolase isozyme during the development of hepatoma in the rat (author's transl)].

Aldolase (ALD) consists of three different types of isozyme, i.e. muscle or A type, liver or B type and brain or C type, their relative proportions being fixed for each tissue. In this study, isozyme profiles in the serum and DAB induced hepatoma as it grows were examined in comparison with those in the fetal liver, in the hope to obtain information for early detection of the malady. In the very early phase of hepatoma growth with no elevated enzyme activity, ALD-A fraction after electrophoresis was found to increase. In the course of hepatoma growth, ALD-B decreased while ALD-A increased with appearance of hybrid of ALD-A and ALD-C. In the normal adult liver, no hybrid of ALD-A and ALD-C was encountered. Serum profile of the rat with DAB induced hepatoma was similar to that of the cancer tissue. On the other hand, the fetal liver shows a profile with high ALD-A fraction and even with hybrid of ALD-A and -C. These features disappeared gradually as maturation proceeded and became close to the adult pattern. Thus it is clear that DAB induced hepatoma exhibits retrogressive change in hepatic differentiation in its isozyme profile. The results also indicate usefulness of isozyme profile for early detection of the hepatoma.

Animals↗