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Biomedical subjects

H Yoshio

Publications and source records attributed to H Yoshio.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Power spectral analysis of heart rate and arterial blood pressure oscillation in brain-dead patients.

To clarify the mechanism of the slow arterial blood pressure oscillation seen in brain-dead patients, we investigated the frequency of fluctuations in arterial blood pressure and heart rate using power spectral analysis. The electrocardiogram, arterial blood pressure and respiration were recorded simultaneously from 9 brain-dead patients and 8 vegetative patients. Power spectral analysis of these data revealed a very slow fluctuation (0.002-0.01 Hz) in arterial blood pressure in brain-dead patients, the frequency of which was equal to that of the low-frequency spectrum of heart rate, indicating vasomotor sympathetic activity. Neuropathological examinations of the medulla and spinal cords of 4 autopsied brain-dead patients revealed that the spinal cord, ventral and dorsal nerve roots, and the nucleus intermediolateralis of the lateral horn below the level of C3/4 were virtually intact. These findings suggest strongly that the slow oscillation of arterial blood pressure in brain-dead patients originates from the vasomotor tone controlled by spinal sympathetic nerves.

Adolescent↗
PubMedDate not supplied

Correlation between myocardial dysfunction and changes in myosin isoenzymes in diabetic rat hearts.

We investigated the relationship between papillary muscle function and the myosin isoenzyme pattern, collagen content, and the type of myocardial collagen in diabetic rats to elucidate the mechanism of short-term myocardial dysfunction in diabetes. Diabetes was induced in 9-week-old male Wistar rats with a single intravenous injection of streptozotocin. One-half of the diabetic rats were treated with insulin. Age-matched control rats were also studied. The time to peak tension (TPT) of isometric papillary muscle contraction, time to 1/2 relaxation, and time from the peak tension to the peak decrease in tension (TPN) were significantly prolonged in diabetic rats at 4, 8, and 12 weeks. The peak increase and decrease in tension were slower in the diabetic rats compared with control rats. The level of the myocardial myosin isoenzyme V3 was greater in diabetic rats than in control rats at each interval. Findings in insulin-treated rats were similar to those in controls. The collagen content and the ratio of type I collagen to type III collagen were similar in all groups. The V3 level was significantly correlated with mechanical parameters (TPT versus %V3: r = 0.81, p < 0.01; TPN versus % V3: r = 0.78, p < 0.01). Our findings suggest that short-term myocardial dysfunction in diabetic rats is related to changes in the myosin isoenzyme pattern.

Analysis of Variance↗
PubMedDate not supplied

Epidemiologic study of Chlamydia trachomatis infection in pregnant women.

GOAL OF THE STUDY: The presence of Chlamydia trachomatis in the cervical canal was investigated in 10,980 married pregnant women and 1,792 unmarried pregnant women who underwent artificial abortions in Hokkaido. STUDY DESIGN: Cervical canal smears were screened for C. trachomatis in pregnant patients. RESULTS: In the married women, the detection rate of C. trachomatis was 5.6% (615 of 10,980 cases). In the unmarried women, the detection rate of C. trachomatis was 15.2% (272 of 1,792 cases). Stratification of the data on the detection of C. trachomatis as a function of the subjects' age showed that, for both the married and the unmarried women, the detection rate increased as the age of the subjects decreased. Analysis of the detection rate of C. trachomatis as a function of the year revealed that it had not changed since 1986. CONCLUSIONS: The findings in this study show that there has been an epidemic of asymptomatic C. trachomatis infections in Hokkaido, especially in young women.

Adult↗