Biomedical subjects

H Zenz

Publications and source records attributed to H Zenz.

17 recordsLinked to original sources

PubMed1990

[Tonometry with a new non-contact tonometer].

We conducted comparative measurements with 100 healthy probands and patients suffering of glaucoma with both a Goldmann Applanation Tonometer (GAT) and the new Keeler Non Contact Tonometer (NCT). A noticeable conformity of mean values in the group I with values under 23 mm Hg and in group II with values greater or equal 23 mm Hg was obvious. The results of three NCT measurement values were compared with those of four measurements. The Keeler NCT nearly fulfills the needed criteria for the first group with pressure under 23 mm Hg except for a high standard deviation. In group II (pressure greater or equal 23 mm Hg) the demanded nominal values are exceeded.

Glaucoma↗

PubMed1989

Taste thresholds in man are differentially influenced by hydrocortisone and dexamethasone.

The present study focused on sensory processing (taste threshold) in healthy young men given different cortisol doses within the normal physiological range. It aimed to differentiate the effects of dexamethasone, a synthetic pure glucocorticoid, compared to hydrocortisone, which has both glucocorticoid and mineralocorticoid properties. In a double-blind, cross-over design, 18 male subjects participated in three sessions. Subjects were pretreated orally with hydrocortisone (50 mg), dexamethasone (2 mg) or placebo. Taste detection was tested by a forced-choice three stimulus drop technique to determine detection acuity and a signal detection procedure to determine the ability to detect differences in NaCl concentration. Cortisol concentrations were determined in blood and saliva. Hydrocortisone and dexamethasone had opposite effects on taste detection acuity. With the highest cortisol levels after intake of hydrocortisone, subjects made more errors in detection trials with respect to stimuli close to the absolute taste detection threshold than after intake of dexamethasone. Detection of differences was impaired by both glucocorticoids. This type of behavioral study in man may help clarify the roles of heterogeneous corticosteroid receptor systems within the human brain.

Adolescent↗

PubMed1983

[Development of gas-driven pump intended for implantation for long-term administration of drugs].

A prototype is presented of a new, implantable therapeutic system for parenteral long-term administration of drugs. It consists of a casing with two chambers separated by a membrane. One of the chambers contains the dissolved substance and includes an interchangeable device to expel the substance. This chamber can be refilled transcutaneously through an opening which is then reclosed. The other chamber contains an isobarically expandable propulsive substance which exerts pressure upon the membrane to cause the solution to be expelled. The liberation time depends upon the particular expelling device used and the viscosity of the medicinal solution. The pharmaceutical and technological aspects of the applicability of this prototype in vitro are examined and discussed.

Drug Implants↗

PubMed1982