Biomedical subjects
Publications and source records attributed to H de Bruyn.
Antibiotics are promoted for the treatment of periodontitis as an adjunct to mechanical debridement. Numerous studies have shown that some topically and systemically administered antibiotics provide an improved short-term clinical effect if used as an adjunct to scaling and rootplaning. However, the few long-term studies (> 5 years) question the clinical relevance.
In this study, patient opinion on oral rehabilitation by means of Brånemark implants was investigated. All patients were referred to a periodontal clinic for implant installation and treated by one and the same operator. Prosthetic restorations were performed by dentists, who had no previous experience with prostheses on implants, but had completed a postgraduate training course. Patient opinion was obtained through questionnaires, pertaining to satisfaction and oral function. A comparison was made between pre-implant situation, short-term (< 4 months) and long-term functioning (3 years) with the implant-restorative rehabilitation. In total, 61 patients participated in the study; 23 received a full lower arch bridge and 18 a full upper arch bridge, while 20 patients got partial bridges. Of 298 installed implants, 7 failed at abutment connection (2.3%) and 1 during the 3-year follow-up interval (0.3%). The study results indicated that a great majority of patients were very satisfied with the treatment. Comfort with eating, aesthetics, phonetics and overall satisfaction improved significantly and nearly all patients said that they would undergo the treatment again or recommend it to others. Patients experienced their implants as "natural" teeth. The conclusion is that rehabilitation ad modum Brånemark, even in the hands of non-specialized dentists, can be of high quality, improving oral function and satisfying the needs and demands of patients.
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A patient with a retained intra-ocular foreign body had a lens extraction for lenticular chalcosis. The lens capsule, examined under an electron microscope, showed copper particles deposited in the basement membrane. The lens capsule and foreign body were examined with an electron microprobe beam. This method proved to be an efficient method of qualitative and quantitative analysis of the contents of the foreign body.
The relationship between the amount of fluoride acquired by human enamel after varnish application and the resulting inhibition demineralization of is presented and discussed. Intact human enamel was pretreated with Fluor Protector varnishes with differing fluoride contents (0.7; 0.1; 0.05 and 0 wt% F-) for 24 hours. In a first experiment the amount of fluoride acquired after application was determined. In a second experiment the pretreated enamel was stored intra-orally under constant plaque coverage, in order to create a substantial demineralization challenge. The protection against demineralization, induced by the various varnishes was determined four months after varnish application using microradiography. Under the cariogenic conditions created in this study, the fluoride containing varnishes induced a protection of 53-75%. Although the amount of fluoride uptake was strongly related to the fluoride content in the varnishes, no statistically significant difference in demineralization inhibition between the varnishes was observed. SEM investigation of the enamel lesions revealed globular precipitates inside the fluoridated enamel, presumably consisting of calcium fluoride-like material. The present study indicates that the fluoride content in Fluor Protector varnishes can be decreased without reducing its ability to inhibit demineralization.
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Fluoride varnishes were developed as alternatives to the conventional topical applications, mainly to prolong contact time between fluoride and teeth. Two marketed products, Duraphat and Fluor Protector, have been extensively tested and are generally accepted for clinical use. In this overview of fluoride varnishes the state of the art of both products is presented. Fluoride uptake, demineralization inhibition and caries prevention induced by varnish applications are discussed. In general it is concluded that varnishes are toxicologically safe, easy to use, and possess excellent cariostatic properties. When re-applied regularly, twice a year, and combined with normal oral hygiene procedures they are topical fluoride agents with very good caries preventive properties.
The inhibiting effect of a 24 hours application of a fluoridated varnish with various fluoride contents on demineralization of human sound enamel was evaluated in vitro. The varnishes used had the same polyurethane base (Fluor Protector) and contained 0.7; 0.1; 0.05 and 0 wt% fluoride, resp. A constant composition technique was used to demineralize varnished and non-varnished specimens at a pH of 5 for periods upto 2 weeks. Microhardness measurements were carried out after several time intervals to follow mineral loss in time longitudinally. At the end of each experimental run microradiography was carried out to investigate 1) lesion type, 2) lesion depth and 3) mineral loss. It is shown in this study that the fluoride releasing varnishes applied on the enamel for 24 hours can inhibit demineralization completely. No demineralization inhibition with the 0% fluoride varnish application was observed.
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