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Biomedical subjects

H von Denffer

Publications and source records attributed to H von Denffer.

At least 19 recordsLinked to original sources
PubMed1991

[MK-507 (L-671 152): local tolerance and effectiveness of a new local carbonic anhydrase inhibitor in healthy probands].

A three-dose, randomized, double-blind parallel, placebo-controlled ocular tolerancy study was undertaken in 24 healthy, normal volunteers with two formulations of 2% MK-507 (L-671 152), a novel water-soluble, topical carbonic anhydrase inhibitor. In this study MK-507 was administered to humans for the first time. Subjects received 3 sequential drops of the test drug in one randomly selected eye (at 13:00, 14:00, and 14:10 o'clock): ten received 2% MK-507 formulated with 0.5% hydroxyethylcellulose (HEC); ten, 2% MK-507 with no HEC; two, vehicle with HEC; and two, vehicle without HEC. Local tolerance of 2% MK-507 was good with predominantly mild and transient local symptoms, somewhat fewer for the formulation without HEC. Significant lowering of intraocular pressure (IOP) by up to 7 mmHg was noted when comparing IOP 4 h and 5 h after the first dose with IOP 20 h and 19 h before the first dose in the treated eyes of subjects receiving MK-507. Slightly greater activity was noted when MK-507 was formulated with HEC.

Adult↗
PubMed1990

[A new topical carbonic anhydrase inhibitor (MK-927). Tolerance comparison with betaxolol in healthy probands].

MK-927 is a new topical carboanhydrase inhibitor with proven ability to lower intraocular pressure in glaucoma patients. Subjective and objective symptoms following topical application of MK-927 were evaluated in a randomized, double-blind, placebo-controlled study in which 24 healthy male volunteers took part. Symptoms were rated according to a visual analog scale by the volunteers and according to a grading scale by the examiner. The study showed good local tolerance of MK-927, comparable to that of Betaxolol.

Administration, Topical↗
PubMed1989

[Comparison of the effect of 0.75% bupivacaine with 0.75% bupivacaine/2% mepivacaine in retrobulbar anesthesia and the effect of adding hyaluronidase].

For about 100 years retrobulbar injection of a local anesthetic has been regarded as being a safe, efficient anesthesia in cataract surgery. Today one of the most difficult steps in cataract surgery is the implantation of the IOL. Vis à tergo can lead to severe problems during this procedure. Therefore, the position of the iris (concave or convex) is an important result that depends on the quality of the block. Motor blockade and analgesia were also examined. The first investigation was done to answer the question of whether or not better results could be obtained by using a mixture of bupivacaine (0.75%) and mepicacaine (2%) or with bupivacaine alone. Injections were done observer-blind in all cases by the same operator. Pure bupivacaine provided the best anesthesia results. A second examination was done in the same way to measure the effects of the addition of hyaluronidase; motor blockade, analgesia und hypotonia of the globe were found to be significantly better with the addition of 75 IU of hyaluronidase.

Aged↗
PubMed1986

[Injuries of the corneal endothelium].

Examples of "endogenous" or direct and "endogenous" or indirect endothelial trauma are presented. Corneal contusion, McCannel suture, YAG laser iridectomy, congenital luxation of the lens, and chronic over wearing of contact lenses all cause traumatic changes. The etiology and effects of these changes are discussed. Specular microscopy of the corneal endothelium permits good clinical control of both the trauma and wound healing.

Adult↗
PubMed1986

[Silicone implant for surgery of therapy-refractory glaucomas].

A silicone implant for surgery of refractory glaucomas has been developed. It consists of a tube 0.64 mm in diameter glued to the upper surface of a plate resembling a contact lens. The surgical procedure, which is similar to a trabeculectomy, is described.

Contact Lenses↗
PubMed1985

[Aqueous humor outflow capacity after argon laser trabeculoplasty. Preliminary report].

In a prospective study of 44 eyes with open angle-glaucoma and 27 with pseudocapsular glaucoma, the aqueous humor outflow facility was controlled for up to 12 months following argon laser trabeculoplasty (ALT). The average increase in the facility of outflow, which was 70% in open-angle glaucoma, was 25% higher in pseudocapsular glaucoma. In successful ALT, this increase in outflow facility was established within the first 20 hours after coagulation and did not decrease during the following year. There were no major complications such as transitory elevations of intraocular pressure, hyphema, or severe uveitis; this fact is interpreted as a result of the authors' technique, in which only the light-pigmented trabecular meshwork is coagulated.

Aqueous Humor↗
PubMed1984

Lacrimal dacryoscintigraphy.

Lacrimal dacryoscintigraphy facilitates definite diagnosis of obstructions and stenosis of the lacrimal drainage system with little stress to the patient. Together with x-ray dacryocystography it is an important diagnostic tool especially for pre- and postoperative evaluation of the drainage apparatus. Dacryoscintigraphy is the best method for measuring the dynamics of tear drainage especially in the canaliculi. Although it is not a substitute for other methods in general use, it complements them and expands their diagnostic accuracy.

Humans↗
PubMed1983

[Calcareous cataract].

In this report on a case of lens calcification the typical X-ray findings, the clinical sings and the unusual concentrations of calcium, phosphates, sodium, potassium and chloride are discussed.

Adult↗
PubMed1980

[Nephropathic and benign cystinosis (author's transl)].

Cystinosis is a rare, autosomally and recessively inherited disorder of amino-acid metabolism with ocular involvement. Four patients with this disease are reported on. The clinical signs of the first patient, who had nephropathic cystinosis, are compared with the signs and symptoms of the benign phenotype (benign cystinosis). In both nephropathic and benign cystinosis, multiple crystals were found in the cornea and conjunctiva. In the second case a large number of crystals were demonstrated in bone-marrow smears and conjunctival sections; a chromatogram of the conjunctiva indicated the presence of cystine. Although the results of an analysis of cultured fibroblasts from this case were contradictory, an elevated cystine level appeared likely. Crystals were also found in conjunctival sections from the third case. In the fourth case it proved impossible to demonstrate crystals clearly in either the bone marrow or in conjunctival sections. There was no evidence of any other cause of the corneal or conjunctival crystals.

Adolescent↗
PubMed1979

Fluorescein angiography and changes in aqueous humor protein after argon laser photomydriasis in rabbits.

In brown-eyed and blue-eyed rabbits, irises treated with argon laser photomydriasis (ALP) were studied by using fluorescein angiography and by evaluating the aqueous humor protein concentration. The following results were obtained. Immediately after ALP, a breakdown of the blood-aqueous barrier is demonstrated by a marked influx of fluorescein into the ciliary processes and into the anterior and posterior chambers. The dye flow into the aqueous humor decreases to normal values within 3 days. There is no fluorescein leakage from laser impacts themselves. Peripupillary capillary loops are permanently occluded, but in a few cases, recanalization occurs. Neovascularization did not occur during 56 days of observation. ALP initially leads to a six- to eightfold increase in normal aqueous humor protein concentration, which decays to normal values within 3 days.

Animals↗
PubMed1979

[Healing of argon laser lesions of the rabbit iris (author's transl)].

Healing of perforating and low dose argon laser lesions of pigmented rabbit irides was studied by light microscopy. Low dose coagulation produced brown stained areas with fibrinous exudation of the surrounding tissue. Healing proceeded with little infiltration of leucocytes leading to an atrophic iris scar with numerous pigment macrophages. Laser iridotomies were closed within 28 days by a scar, shaped by proliferating cells and newly formed collagen fibrils. Lesions of the epithelium of the lens were demonstrated by hemalum staining of the nuclei, even in cases, when no lens opacities could be detected by biomicroscopy.

Animals↗
PubMed1978

[Scintigraphy of the lacrimal draining system].

A new scintigraphic method, the radionuclide dacryography, to evaluate lacrimal drainage and its disorders is described. A drop of 99mTc-pertechnetate is dropped onto the eyes and the transport of the nuclide is registered by a scintillation camera. By this method it is easy to verify, under physiological conditions, suspected obstructions of the lacrimal drainage system and to determine its localization. The absorbed radiation dose using radionuclide dacryography is very low as compared to radiological methods.

Dacryocystitis↗