Biomedical subjects

Héla Elloumi

Publications and source records attributed to Héla Elloumi.

6 recordsLinked to original sources

PubMed2005

[Predictive factors of recurrence in Crohn's disease].

BACKGROUND AND AIMS: The aim of this study is to determine the factors associated with high risk of recurrence of Crohn disease. PATIENTS AND METHODS: During 12 years period from January 1987 till December 1999, 98 patients treated for Crohn's disease were included in this study. The risk of recurrence was studied using the Kaplan-Meier method. The possible predictive factors of recurrence were studied using the LOGRANK test. RESULTS: During the follow-up period, 50 (66%) patients developed a recurrence of Crohn's disease. The factors associated with a high risk of recurrence of the diseases were female (p=0.03), long delay before the diagnosis of the disease (p=0.03) and the presence of extra-intestinal lesions (p=0.05). Concerning other factors such as the age, smoking, inflammatory syndrom and ano-perineal lesions, the study showed no relationship between these factors and the recurrence of the disease. CONCLUSION: This study showed that the group of patients treated for Crohn's disease and who have predictive factors of recurrence should have prophylactic medical treatment to prevent recurrence of the disease.

Adolescent↗

PubMed2005

[Importance of vaccination chronic hepatitis B].

Weak therapeutic responses and weak immune cytotoxic CD8 and CD4 response in chronic hepatitis B emphasize the necessity to find new therapeutic strategies especially as specific immunotherapy. Vaccination, whose principle was to widen immune repertoire, was used as a curative treatment of chronic hepatitis B. It would be the therapeutic procedure with the lowest cost and the potentially greatest benefit. Our purpose was to enhance the interest of therapeutic vaccination in chronic hepatitis B in order to debate later its usefulness in developing countries.

Hepatitis B Vaccines↗

PubMed2004

[Modalities and interest in followup of colorectal cancers after curative surgery].

Recurrence is found in 24 to 50% in patients undergoing surgery for colorectal cancer. The main purpose of follow-up is the screening of local or metastatic recurrence. Actually, the follow-up can not be justified only if there is a real advantage for the patient. Optimal modalities of surveillance of colorectal cancers resected have not been determined. The search of liver or lung metastases is actually preferred. The same pattern is used for searching colorectal lesions after a resection of colorectal cancer and after a polypectomy. The cost/effectiveness deontological value must be considered in the choice of further exams. However, the contribution of a cancerology follow-up is always controversial. Only prospective and randomized trials with a sufficient number of patients would prove the usefulness of a follow-up. In order to minimize the cost's problem, it is interesting to propose follow-up for a target population with a greater individual risk for recurrence.

Biomarkers, Tumor↗

PubMed2004

[Non alcoholic steatohepatitis: an emergent and potentially serious pathology].

Nonalcoholic steatohepatitis is an acquired liver disease, usually metabolic characterised by histologic lesions with steatosis, intralobular necrosis and inflammatory infiltrates. Liver biopsy findings are identical to those seen in alcoholic hepatitis. Nonalcoholic steatohepatitis is increasingly reported in industrial countries because of an increase of the prevalence of obesity and diabetes which are the most common risk factors of this disease. The diagnosis of nonalcoholic steatohepatitis is based on a confrontation between clinical and anatomic data and an exclusion of an excessive intake of alcohol and other hepatic disease. Liver biopsy has a prognosis and histologic benefit especially when there is risk factors of fibrosis. This disease is potentially severe with a potential risk for progression to cirrhosis. Progress in pathogenesis is noted but no definite therapy exist. The aim of this review is to indicate current knowledge for the gravity of nonalcoholic steatohepatitis and its consequence and to understand the pathogenesis to prevent cirrhosis.

Fatty Liver↗

PubMed2004

[Octreotide in the treatment of acute gastrointestinal hemorrhage caused by ruptured esophageal varices].

AIMS: To asses the value of octreotide in the control of acute bleeding esophageal varices in a retrospective study. METHODOLOGY: Fourty two patients admitted for esophageal variceal bleeding confirmed at endoscopy were recruited. An initial 50 micrograms bolus of octreotide followed by a two day continuous infusion of 25 micrograms/h were evaluated for the control of bleeding. RESULTS: Twenty nine patients were endoscopic stigmata of recent bleeding and thirteen were active bleeding at emergency endoscopy. Octreotide was found to be effective regarding hemostasis at 48 hours and on day 7 after the index bleeding episode. 30-day mortality was 11.9%. Echec of octreotide was significantly associated with severity of cirrhosis (p<0.03). CONCLUSION: These results suggest that octreotide is effective in the treatment of esophageal variceal bleeding and it is a valuable adjuvant treatment in association with endoscopic management.

Acute Disease↗

PubMed2003

[Gastrointestinal stromal tumors. Current data].

GIST anatomical concept, recently elucidate, they are characterized by the expression of the protooncogene C Kit The diagnosis is relatively easy but prognosis evaluation is not usually possible. The treatment is based on the surgical resection. The rewardable clinical response of tumors that express C-Kit to treatment with the tyrosine kinase inhibitor STI 571 is a triumph of molecular pharmacology.

Antineoplastic Agents↗