Biomedical subjects

H-Y Huang

Publications and source records attributed to H-Y Huang.

3 recordsLinked to original sources

PubMed2006

Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns.

The purpose of this study was to evaluate the treatment results and failure patterns of lymphoepithelioma-like carcinoma (LELC) of salivary glands. From June 1987 to May 2001, nine patients with LELC of salivary glands were treated at our hospital. One patient was excluded due to the loss of clinical follow-up after surgery. For the remaining eight patients, the primary tumour sites were parotid glands (4 patients), submandibular glands (3), and the minor salivary glands in right cheek (1), respectively. Seven patients underwent surgical treatment and post-operative radiotherapy, while the other one patient was treated with surgery only. The total radiation dose to the salivary tumour bed ranged from 39.6 Gy to 67.6 Gy (mean dose: 58.3 Gy and median dose: 59 Gy). The treatment results and failure patterns were analysed. The survival time ranged from 21.4 months to 145.2 months (mean: 69.1 months, median: 54.5 months). At the end of follow-up, six patients were still alive and two died. One patient died of distant metastases 21.5 months after the surgical treatment of LELC. The other case died of intercurrent disease (pontine haemorrhage) 53 months after surgery. No patient had local or regional failure after the treatments. Distant failure was noted in two patients. The patients with LELC of salivary glands were shown to have favourable prognoses. No local or regional failure was noted. However, distant failure developed in two patients. The risk of distant metastasis should be carefully monitored, especially for those patients with more advanced neck node involvement.

Adult↗

PubMed2002

Sclerosing perineuriomas affecting bilateral hands.

Sclerosing perineurioma is a rare, recently described variant of perineurioma that tends to affect the fingers and palms of adolescents or young adults. The process typically presents as a painless, well-circumscribed, unencapsulated nodule involving subcutis or reticular dermis. To our knowledge, all of the previously reported sclerosing perineuriomas were solitary. Hence, we report a 16-year-old boy, without stigmata of neurofibromatosis, who developed one sclerosing perineurioma in the right palm and another on the left index finger. Microscopically, tumours at both sites revealed small epithelioid and plump spindle cells with trabecular, whorled, or Indian file growth pattern enmeshed within extensively hyalinizing stroma. Immunohistochemically, the tumour cells showed strong reactivity for EMA but negative staining for S-100 and neurofilament. Ultrastructually, the tumour cells in both lesions exhibited features of perineurial cells, including discontinuous external basal lamina, occasional pinocytotic vesicles, and encirclement of abundant collagen fibrils by the interdigitating cytoplasmic processes. This case confirms the fact that sclerosing perineurioma is not always solitary.

Adolescent↗

PubMed2002

Atypical leiomyoma of the urinary bladder--a rare tumor occurring in a young female with concurrent breast carcinoma--an influence of sex steroid hormone?

Smooth muscle tumors are uncommon in the urinary bladder, and atypical leiomyoma of the urinary bladder is extremely rare. We report a case of atypical leiomyoma with a concurrent breast carcinoma and discuss the pathologic features, the possible etiology and clinical outcome of the tumor.

Adult↗