Calculation of brachytherapy doses does not need TG-43 factorization. For the proposition.
Explore the source record for details and available documents.
Algorithms↗
Biomedical subjects
Haijun Song
Publications and source records attributed to Haijun Song.
Protocols for the dosimetry of high-energy photon and electron beams: a comparison of the IAEA TRS-398 and previous international codes of practice. International Atomic Energy Agency.
A new international Code of Practice for radiotherapy dosimetry co-sponsored by several international organizations has been published by the IAEA, TRS-398. It is based on standards of absorbed dose to water, whereas previous protocols (TRS-381 and TRS-277) were based on air kerma standards. To estimate the changes in beam calibration caused by the introduction of TRS-398, a detailed experimental comparison of the dose determination in reference conditions in high-energy photon and electron beams has been made using the different IAEA protocols. A summary of the formulation and reference conditions in the various Codes of Practice, as well as of their basic data, is presented first. Accurate measurements have been made in 25 photon and electron beams from 10 clinical accelerators using 12 different cylindrical and plane-parallel chambers, and dose ratios under different conditions of TRS-398 to the other protocols determined. A strict step-by-step checklist was followed by the two participating clinical institutions to ascertain that the resulting calculations agreed within tenths of a per cent. The maximum differences found between TRS-398 and the previous Codes of Practice TRS-277 (2nd edn) and TRS-381 are of the order of 1.5-2.0%. TRS-398 yields absorbed doses larger than the previous protocols, around 1.0% for photons (TRS-277) and for electrons (TRS-381 and TRS-277) when plane-parallel chambers are cross-calibrated. For the Markus chamber, results show a very large variation, although a fortuitous cancellation of the old stopping powers with the ND,w/NK ratios makes the overall discrepancy between TRS-398 and TRS-277 in this case smaller than for well-guarded plane-parallel chambers. Chambers of the Roos-type with a 60Co ND,w calibration yield the maximum discrepancy in absorbed dose, which varies between 1.0% and 1.5% for TRS-381 and between 1.5% and 2.0% for TRS-277. Photon beam calibrations using directly measured or calculated TPR20,10 from a percentage dose data at SSD = 100 cm were found to be indistinguishable. Considering that approximately 0.8% of the differences between TRS-398 and the NK-based protocols are caused by the change to the new type of standards, the remaining difference in absolute dose is due either to a close similarity in basic data or to a fortuitous cancellation of the discrepancies in data and type of chamber calibration. It is emphasized that the NK-ND,air and ND,w formalisms have very similar uncertainty when the same criteria are used for both procedures. Arguments are provided in support of the recommendation for a change in reference dosimetry based on standards of absorbed dose to water.
Air↗
Accelerator-based neutron brachytherapy.
The development and evaluation of a new approach to neutron brachytherapy is described. This approach, accelerator-based fast neutron brachytherapy, involves the interstitial or intracavity insertion of a narrow, evacuated accelerator beam tube such that its tip, containing the neutron-producing target, is placed in or near the tumor. Tumor irradiation via brachytherapy should result in a reduction in the healthy tissue complication rate observed when poorly collimated and/or low energy external neutron beam are used for treatment. Use of a variable energy accelerator provides an advantage over isotope sources for neutron brachytherapy in that the neutron beam can be turned on and off and the neutron energy spectrum varied for different treatment applications. A prototype accelerator-based fast neutron brachytherapy device, 10 cm long and 6 mm outer diameter, has been constructed and evaluated in terms of its dosimetric output, treatment time, and practical feasibility. The prototype device is a tube-in-tube design with cooling water running between the inner and outer tubes to cool a beryllium target located at the tip of the inner tube. Cooling experiments were performed and coupled with Monte Carlo simulations to determine treatment times as a function of heat load for various neutron-producing reactions. Using the 9Be(d,n) 10B reaction at Ed= 1.5 MeV, 66 RBE-Gy (12 Gy physical dose) can be delivered to the boundary of a 4.5-cm-diam treatment volume in 8 min at a heat load of 130 W. Other reactions offer similar treatment times at somewhat higher bombarding energies and also show higher potential for dose enhancement with the boron-10 neutron capture reaction due to their softer neutron spectra. Dose distributions in a water phantom were measured with the prototype brachytherapy tube using the dual-ion chamber technique for the 9Be(d,n) 10B reaction at Ed = 1.5 MeV. The measurements and simulations agree within uncertainties and demonstrate that fast neutrons contribute more than 90% of the dose to the target volume.
Brachytherapy↗
Comparison of characteristics of photon and electron beams generated by Philips/Elekta and Varian linear accelerators.
Commissioning data of the common energy of 6 MV photon beams are analyzed for seven Philips/ Elekta linacs of five different models: SL 75/5, SL 15, SL 25, SLi Precise, and SLi. The observed beam quality %dd(10)x of 67.7% +/- 0.3 agrees with the manufacturer's specification of 67.5% +/- 2% but with a much smaller variation, suggesting the possibility of a more accurate beam quality guideline for acceptance commissioning of these linac models. Field size factors are less uniform, especially for the biggest field size of 40 x 40 cm2, but all agree within 1.1% between the five models. These 6 MV photon beams are also shown to be 0.4 MV harder than the Varian 2100C model. For commissioning electron beams generated by the Philips/Elekta models SL 15, SLi Precise and SLi, guidelines can be found from this work for the following parameters: actual field size at 100 SSD (up to +/- 0.6%) (different from manufacturer specified values at 95 SSD), and virtual source distance (up to +/- 0.7%). Significant differences are seen for R50 (up to 3.7 mm), sigma-theta-x, effective source distance, and cone size factor. However, except for R50 where Varian 2100C datasets are not available for comparison, the differences between the different Philips/Elekta models are comparable to those between the same Varian 2100C model linacs measured by us and Watts.
Electrons↗
Measured TG-60 dosimetric parameters of the Novoste Beta-Cath 90Sr/Y source trains for intravascular brachytherapy.
Measurements were performed on the 30, 40 and 60-mm 90Sr/Y beta-emitter source trains used in the Novoste Beta-Cath system to determine the dosimetric characteristics of the sources at millimeter distances and provide the necessary TG-60 dosimetry parameters for mapping the dose distributions. These measurements were carried out in a Solid Water phantom where MD-55-2 Gafchromic films were placed in direct contact with a 5 French (F) catheter used for the 30 and 60-mm source trains and a 3.5 F catheter used for a thinner 40-mm source train. The dosimetric analysis was performed according to the AAPM TG-60 formalism. For the 30-mm source train, data were collected with the source axis at distances of 0.41 and 1.19 mm from the film surface, respectively, in order to investigate possible dosimetric effects due to the intrinsic off centering of the source train lumen within the 5 F catheter. Absolute dose rates at 2 mm were determined by calibrating the radiochromic film in a high energy electron beam from a radiotherapy accelerator. The dose rates at a radial distance of 2 mm were found to be within 10% of the values provided by Novoste. Radial dose functions from this study were in good agreement (< or = 10%) with a 30-mm, 90Sr/Y source train dose data generated from C. G. Soares et al. 90Sr/Y single seed data. However, larger differences were observed at distances shorter than 1 mm when compared to radial dose functions from the Novoste Monte Carlo data.
Beta Particles↗