Biomedical subjects

Hakan Güven

Publications and source records attributed to Hakan Güven.

5 recordsLinked to original sources

PubMed2005

Diagnostic value of ultrasonography in the evaluation of blunt abdominal trauma.

PURPOSE: To evaluate the diagnostic value of ultrasonography (US) in detecting intraabdominal injuries in patients with blunt abdominal trauma. MATERIALS AND METHODS: Blunt trauma patients admitted to the emergency department from January 2002 to August 2003 were retrospectively evaluated. A total of 454 patients with blunt abdominal trauma who underwent US examination were included. Ultrasonography results were compared with findings of CT, diagnostic peritoneal lavage, laparotomy and clinical course. Sensitivity, specificity, positive and negative predictive values of US in detecting free fluid, intraabdominal parenchymal organ injury or both were calculated. RESULTS: Computed tomography, diagnostic peritoneal lavage and laparotomy results showed that intraabdominal organ injury was present in 37 of 454 patients. Ultrasonography examinations were positive in 51 patients. True-positive findings were seen in 32 of these patients. In these 32 patients, US examination showed free fluid in 19, fluid and abdominal organ injury in 11 and only abdominal organ injury in 2. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of US in detecting intraabdominal injury were 86.5%, 95.4%, 62.7%, 98.7% and 94.7%, respectively. CONCLUSION: Ultrasonography has high diagnostic performance in the screening of patients with blunt abdominal trauma. Abdominal US is a useful and valuable diagnostic tool after clinical evaluation in patients with blunt abdominal trauma. Because of its high negative predictive value, we recommend that clinical follow up is adequate for patients whose US results are negative for intraabdomial organ injury.

Abdominal Injuries↗

PubMed2003

[A practical volume controlled bleeding method in animal hemorhagic shock model].

The bleeding method is the most widely used technique in volume controlled hemorrhagic shock model that was described as withdrawing blood by an heparinized syringe from veins of laboratory animals. However the difficulty in establishing a constant bleeding rate and volume at a desired time is the major disadvantage of this technique. This disadvantage may also lead to the mortality during the exsanguinating phase due to inconstant bleeding rate. Reversely connected infusion pump that was described in this report is a useful and practical method to withdraw blood with predetermined bleeding volume and rate. The described method can easily be applied to various pathophysiological and metabolic studies on acute blood loss.

Animals↗

PubMed2003

[The incidence of pathologic findings of the cranial computed tomography in patients with minor head trauma and its correlation with age and clinical features].

BACKGROUND: Our objective was to determine the incidence of diagnosing lesions by cranial computed tomography (CT) and to evaluate prospectively whether this incidence correlated with clinical features and age in patients with minor head trauma (MHT). METHODS: This prospective study included 78 patients with MHT. All of the cases underwent CT following their clinical assessment. RESULTS: In the 34.61% of cases, there was a pathologic finding in the CT however the incidence of intracranial injury was 15.38%. There were no significant differences between children (n:22) and adults (n:56), the patients with and without a history of the loss of consciousness/amnesia and the patients with and without clinical symptoms (p>0.05). CONCLUSION: Our results support the studies which have reported that there is no non-focal clinical factor as a predictor for pathologic CT findings.

Adolescent↗

PubMed2002

[Management of brain edema in acute head injury].

BACKGROUND: We aim was to review the basic concepts and to analyze the current management of cerebral edema following acute head trauma (AHT). METHOD: Cerebral edema should be recognized and treated early and aggressively to avoid disastrous results such as cerebral herniation. After clinical evaluation and early cardiorespiratory stabilization, the patients should be treated with the elevation of head, oxygen, mannitol, hyperventilation, and sedation-myorelaxation and may avoid from hypotension-hypoxia. If these treatments be unsuccessful, barbiturates may be used. There are also other possibilities such as hypothermia, ventriculostomy, hypertonic saline and neuroprotector agents. CONCLUSIONS: All patients with AHT should be evaluated early and cerebral edema should be treated with correct therapy. Therefore, the mortality and morbidity rates may reduce.

Barbiturates↗

PubMedDate not supplied

Low dose dopamine prevents end organ damage in experimentally induced pancreatitis.

BACKGROUND/AIMS: End organ damage due to microcirculatory failure plays an important role in the pathogenesis of acute pancreatitis (AP). The aim of this study was to investigate whether dopamine, a vasoactive agent, is beneficial in the prevention of local and systemic injury in acute pancreatitis. METHODOLOGY: Pancreatitis was induced in rats with 5% Na-taurocolic acid infusion into the pancreatic duct. Rats were resuscitated for four hours with saline in the pancreatitis group (P), lactated ringer's (LR) solution in the LR group and low dose dopamine (5 microg/kg/min) + LR in the D-LR group. The sham group (S) underwent pancreatic duct cannulation only. Rectal temperature (RT) and meanarterial pressure (MAP) were monitored throughout the experiment. Blood samples for amylase, lipase, WBC and blood gas analysis were taken at baseline and at the end of the study. All rats were sacrificed at the 4th hour and pancreatic and lung tissues were removed for histopathological examination and tissue myeloperoxidase (MPO) activity. RESULTS: MAP was lower in the P and LRgroups than the sham and the D-LR groups. RT was higher in P and LR groups than the sham and the D-LR groups. Base deficit was higher in the P group than the sham and the D-LR groups. The lung MPO activity was higher in the P group than all the others. Lung MPO activity that is closest to the sham was that of D-LR group's. The pancreatic MPO activity was found to be increased in the P and decreased in the LR groups. CONCLUSIONS: In this experimental model for AP, low dose dopamine + LR resuscitation attenuates the lung injury but not the local pancreatic injury.

Acute Disease↗