Biomedical subjects

Halina Woś

Publications and source records attributed to Halina Woś.

6 recordsLinked to original sources

PubMed2006

[Echocardiographic assessment of cor pulmonale in patients with cystic fibrosis].

Cystic fibrosis (CF) is an inherited multisystem disorder, characterized mainly by obstruction and infection of airways and by maldigestion and its consequences. An increasing interest concerning patients suffering from CF has been observed. Aim of this study was echocardiographic study of morphological structure, functional index and the grade of pulmonary hypertension in patients with CF. In 45 patients aged 3 to 24 years (mean 15.1 years) echocardiography was performed. Right ventricular end-diastolic dimension (RVDd) was increased in 67% of patients, right ventricular anterior wall thickness (RVAWd) was increased in 71% of patients. Pulmonary artery pressure was abnormally high in 84% of CF patients. Significant correlations between RVDd, RVAWd, PAP and Shwachman-Kulczycki clinical score was found. The dimensions of the left ventricular cavity were abnormal in 22% of patients. Insufficiency of pulmonary valve was observed in 47% of CF patients and tricuspid insufficiency in 53%. This study demonstrates that: 1) changes occurs mainly in right ventricle and appear to worsen as the disease progresses, 2) all patients with CF should remain under cardiological control, 3) echocardiography could be a useful method of long-term monitoring patients with CF.

Adolescent↗

PubMed2005

[Clinical picture of celiac disease in children].

UNLABELLED: During the last few years we have been observing the decreasing incidence of the symptomatic celiac disease and increasing incidence of mono- and asymptomatic disease. Various atypical symptoms and extraintestinal manifestations were observed in older children (above 7 years) and in adults. Clinical symptoms of celiac disease may appear at any age, in each of the following forms: clinical celiac disease (symptomatic), silent (oligosymptomatic) or latent, with late manifestation, being the effect of stress, pregnancy, infections or excessive dietary gluten provocation. THE AIM OF THE STUDY: The presentation the variety of clinical pictures of celiac disease in children. MATERIALS AND METHODS: We have evaluated the clinical course of celiac disease in 16 children (13 girls and 3 boys), aged between 12 months to 17 years (mean-7,5 years). The celiac disease was diagnosed on the grounds of clinical symptoms, histopathological examination of the small intestinal endoscopic biopsy and immunological examinations: serum antitransglutaminase antibodies and anti-endomysium antibodies. RESULTS: Most commonly diagnosed form was the silent, monosymptomatic celiac disease. Four children manifested with growth retardation, one with osteoporosis, and one with iron deficiency anemia resistant to treatment. Two girls (aged 16 and 17 years) presented with symptomatic celiac disease. In 3 patients despite the gastrointestinal symptoms and histopathological changes present (villous atrophy, Marsh's index > 40) we did not find any immunological markers of celiac disease (with normal IgA levels). CONCLUSIONS: School-aged children with celiac disease, in many cases have no evident clinical and functional disorders caused by gluten intake, despite to presence of considerable abnormalities in the histopathological examination.

Adolescent↗

PubMed2004

[Infections of Salmonella in children aged 0-36 months--clinical and epidemiological aspects].

In this work we presented a retrospective analysis of Salmonella infections in 163 children aged between 0-36 months. The children were treated in IV Department of Pediatrics at Medical University of Silesia (Poland) in years 1987-1998. We analyzed: clinical course, dependence between age of the patients and the type of Salmonella, number of infections and their seasonal incidence during 12 years of observation. These relations were compared with the group of 17 children with Salmonella infections treated in the Department of Pediatrics GCZDzM in Katowice in 2001.

Child Welfare↗

PubMedDate not supplied

[Basal concentration of Substance P (SP) and Vasoactive Intestinal Peptide (VIP) in the blood serum of children with allergic dermatitis].

UNLABELLED: Substance P (SP) and Vasoactive Intestinal Peptide (VIP) neuropeptides play a role in the immediate and late type of hypersensitivity as well as in neurogenic inflammation. This suggests their participation in the etiology of allergic dermatitis. In the changed skin of patients with allergic dermatitis considerable increase of nervous endings was found containing SP and VIP. The aim of the study was the evaluation of SP and VIP concentration in blood serum of children with allergic dermatitis in the course of food allergy. PATIENTS AND METHOD: We determined by radioimmunological method on empty stomach concentration of SP and VIP in the blood serum in 19 children, aged between 6 and 24 months with allergic dermatitis of various intensity. In the 6 children with alimentary tract symptoms and deficiency of body mass we have done biopsy of the small intestine mucosa. RESULTS: Obtained medium values of SP and VIP were higher in the examined group in the comparison to the control group, but we did not find any statistical significance. However, in the group of children with co-existent malabsorption syndrome we found higher concentration of both neurohormones and we found statistical significance in the concentration of SP in comparison to children from the control group. CONCLUSIONS: Although SP and VIP are mainly secreted to the surrounding tissues and in a smaller degree endocrinally to the blood, increased level of these neurohormones in the blood serum in children with allergic dermatitis may confirm their contribution to the pathomechanism of this form of allergy.

Case-Control Studies↗

PubMedDate not supplied

[Mediastinal involvement in the course of proliferative diseases in children in the materials of one institution].

UNLABELLED: The mediastinum region may be the primary or secondary localization of neoplasms. The aim of our study was the assessment of clinical symptoms, histopathology and outcome of mediastinal tumours in children. MATERIALS AND METHODS: A group of 27 children, chosen from the group of 128 patients with malignancies, which were treated in the years 2000-2004 in the Oncology and Haematology Unit of the Paediatric Department in Katowice, has been studied. In this group there were 14 boys and 13 girls at the age between 2 and 12 years. We analysed the clinical symptoms prior to the diagnosis and the duration of these symptoms, histologic type of tumours and results of treatment. RESULTS: The primary localization in the mediastinum was diagnosed in 23 patients (85,2%) among them 15 (55,5%) of these children have been diagnosed as having Hodgkin's disease, and in 8 (29,6%) non Hodgkin's lymphoproliferative disease. Four of the children (14,8%) had mediastinal secondary localization of solid tumours (2 - neuroblastoma, 1 - carcinoma suprarenalis, 1 - carcinoma epitheliale of unknown origin). The most frequent symptoms were: fever (70,3%), weakness (66,6%), cough (55,5%), madiastinalpain (33,3%). The duration of these symptoms prior to the diagnosis was between 5 days and 182 clays. CONCLUSIONS: 1. In the group of neoplasms localized in the mediastinum, lymphoproliferative diseases are the most frequently diagnosed disorders. 2. In case of fever of unclear etiology and persistent cough, it is necessary to exclude mediastinal malignancy. 3. There is a need to improve the system of oncological education for medical students and doctors.

Carcinoma↗

PubMedDate not supplied

[Orbital pseudotumour imitating a proliferative process].

INTRODUCTION: Orbital pseudotumour is a non-specific inflammatory process of the orbit of unknown origin. It is a rarely diagnosed disease particularly in children, which imitates a neoplastic process. Typical clinical picture is a tumour localized in the orbit, causing various degree of exophtalmus and a decrease of globe mobility and vision. The extent of intraorbital changes are revealed by imaging studies (USG, TK, MR). Diagnosis is based on histopathology of tumour sample. In treatment steroid therapy, radiotherapy or chemotherapy in resistant cases are used. Relapse and malignant transformation are observed. CASE REPORT: We present a case of a 5-years old girl with orbital pseudotumour. In the histopathological examination there a small lymphoid cells, immunohistochemically there is mixed lymphocytic T and B infiltration (CD 3 (+), CD 20 (+), bcl (+), CD 43 (-)). She was treated with steroid therapy, and achieved complete regression of the tumour. At present she is regularly oncologically examined because of the possibility of malignant transformation. CONCLUSIONS: 1. Orbital pseudotumour should be included in the differential diagnosis of children with an orbital tumour 2. Corticosteroids seem to be the treatment of choice in orbital pseudotumour 3. Children with orbital pseudotumour should be regularly oncologically examined because of the possibility of malignant transformation.

Child↗