Biomedical subjects

Hamid Nasri

Publications and source records attributed to Hamid Nasri.

8 recordsLinked to original sources

PubMed2006

Correlation of serum magnesium with serum parathormone levels in patients on regular hemodialysis.

Secondary hyperparathyroidism (SHPT) is a common, important, and treatable complication of end-stage renal disease. This study was conducted to investigate the role of serum magnesium (Mg) in regulating the secretion of parathyroid hormone (PTH) by the parathyroid gland in patients on maintenance hemodialysis (HD). Pre-dialysis serum levels of calcium (Ca), phosphorus (P), Mg, alkaline phosphatase (ALP), intact serum PTH (iPTH), serum 25-hydroxy Vitamin D (25-OH Vit D) and plasma bicarbonate (HCO3) were measured. The Urea Reduction Rate as well as duration and dosage of HD treatment were noted. Our study did not show any significant correlation between serum Mg levels and duration of HD treatment, levels of serum ALP, and plasma HCO3, Ca and P. An inverse correlation, albeit insignificant, was found between the serum Mg levels and iPTH (r = -0.30 p = 0.079); also, a significant positive correlation was found between serum Mg levels and serum 25-OH Vit D levels (r = 0.40 p = 0.009). Our findings are in agreement with previous data, which suggest that factors other than serum Mg are more important in the regulation of PTH secretion in HD patients. A positive and strong association between serum Mg with 25-OH Vit D needs to be studied in greater detail.

Adolescent↗

PubMed2006

Association of serum leptin with anemia in maintenance hemodialysis patients.

To evaluate the relationship between hyperleptinemia and anemia in hemodialysis patients, we investigated the reverse epidemiological role of leptin in 36 patients (males: 21, diabetics: 11) under regular chronic hemodialysis. The patients had complete blood counts, iron profile, serum leptin, and adequacy of hemodialysis measured. We found a significant positive correlation of serum leptin with hemoglobin level and body mass index (BMI). A trend between serum leptin and total iron binding capacity was observed, however, no correlation was observed with serum ferritin. No differences in these correlations were observed in any subgroup related to gender or diabetes. Our data support previous findings showing that greater serum leptin levels are associated with greater hemoglobin levels.

Adult↗

PubMed2006

The relationship between serum LDL-cholesterol, HDL-cholesterol and systolic blood pressure in patients with type 2 diabetes.

BACKGROUND: The prevalence of hypertension and lipid disorders is increased in patients with diabetes. The relationship between cholesterol and blood pressure values has not yet been well established in this group of patients. AIM: To assess the correlation between lipid levels and blood pressure values in patients with type 2 diabetes. METHODS: The study group consisted of 122 patients (82 females, 40 males, mean age 63+/-10 years) with type 2 diabetes. The mean duration of diabetes was 7.4+/-5.8 years, and hypertension 3.2+/-4.6 years. In all patients glycosylated haemoglobin (HbA1c) and lipid serum concentrations were assessed. RESULTS: The mean serum LDL-cholesterol was 112+/-37 mg/dl (median: 112 mg/dl) and HDL-cholesterol - 47+/-18 mg/dl (median: 44 mg/dl). A significant inverse correlation between HDL-cholesterol and systolic blood pressure (r=-0.177, p=0.05) as well as a positive correlation between LDL-cholesterol and systolic blood pressure values (r=0.196, p=0.031) were found. CONCLUSION: In patients with type 2 diabetes there is a significant relationship between lipid levels and blood pressure values, which suggests an increased susceptibility to vascular disease associated with LDL-cholesterol in these patients.

Adult↗

PubMed2005

Serum C-reactive protein (CRP) in association with various nutritional parameters in maintenance hemodialysis patients.

Malnutrition and inflammation are common in hemodialysis (HD) patients, and are usually closely associated. Serum C-reactive protein (CRP) concentrations have been found to be significantly elevated in hemodialysis patients and reflects chronic inflammation, and as an acute-phase reactant, is a sensitive and independent marker of malnutrition. To investigate the association of serum CRP level with some nutritional variables in diabetic and non diabetic end-stage renal failure patients undergoing regular hemodialysis, we designed a study on 36 maintenance hemodialysis patients (f = 15, m = 21), consisting of 25 non-diabetic HD patients and 11 diabetic HD patients. In this study a near significant difference of CRP between diabetic and non-diabetics of all patients with more values of CRP in diabetics and a significant difference of CRP between diabetic and non-diabetics of female HD patients with more values in diabetics were seen. A significant difference of CRP between males and females of non-diabetic population with more values of CRP in males was found too. An inverse correlation of serum CRP with serum cholesterol and triglyceride levels and a near significant positive correlations of CRP with serum ALP and with serum intact parathormone (iPTH) were found too. An inverse correlation of serum CRP with dialysis efficacy was also seen. No significant association between serum CRP and serum albumin was seen. Compatible with some studies and in contrast to some other studies, the association of serum albumin with serum CRP levels in this study was insignificant. The positive correlation of high serum iPTH with inflammation implies further need to control hyperphosphatemia and secondary hyperparathyroidism in HD patients, also inverse correlation of serum CRP with cholesterol and triglyceride further support the malnutrition-inflammation complex syndrome (MICS) which frequently seen in hemodialysis patients (Tab. 3, Fig. 3, Ref. 42).

Adolescent↗

PubMed2004

Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis.

BACKGROUND: Cardiovascular risk factors are a significant burden in end-stage renal disease patients under hemodialysis. Cardiovascular-related diseases are the leading cause of death among these patients and responsible for almost half of all deaths in dialysis patients. The influence of parathormone (PTH) on myocardial function as a toxin of uremia is attracting more attention and evaluation because of growing evidence that the effects of PTH on cardiac function may be the most serious consequence of secondary hyperparathyroidism in renal failure. In this study we aimed to consider the role of the excess PTH in the development of left ventricular hypertrophy (LVH) and its effects on LV ejection fraction in patients with end-stage renal disease under regular hemodialysis. METHODS: This cross-sectional study was done on patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis treatment. Calcium, phosphorus, alkaline phosphatase and intact PTH (iPTH) were measured. Hypertensive patients were stratified into stages one to three. Echocardiography for left ventricular (LV) hypertrophy and ejection fraction (percent) were done and LV stratified into normal, mild, moderate and severe hypertrophy. RESULTS: The total number of patients was 73 (F = 28, M = 45), consisting of 58 non-diabetic hemodialysis patients (F = 22, M = 36) and 15 diabetic hemodialysis patients (F = 6, M = 9). The age of patients was 46.5 +/- 16 years. The length of time patients had been on hemodialysis was 21.5 +/- 23.5 months. The LV ejection fraction (EF%) was 51 +/- 8 percent. Mean +/- SD of iPTH of total patients was 309 +/- 349 pg/ml. Mean +/- SD of iPTH of diabetic group and non-diabetic group was 234 +/- 265 pg/ml and 329 +/- 368 pg/ml respectively. The value of serum alkaline phosphatase of total patients was also 413 +/- 348 IU/L. Serum alkaline phosphatase (ALP) of diabetic group and non-diabetic group was 295 +/- 179 IU/L and 443 +/- 375 IU/L respectively. Serum albumin of total patients was 4 +/- 0.75 g/dl. Serum albumin of diabetic group and non-diabetic group was 3.6 +/- 0.7 g/dl and 4.2 +/- 0.7 g/dl respectively. Significant inverse correlation of serum ALP with percent of LV ejection fraction and marginal significant correlation of serum ALP with LVH were seen and marginal significant correlation of serum iPTH with LVH was also found. Significant inverse correlation between serum iPTH with percent of LV ejection fraction in non-diabetic HD patients was observed. CONCLUSIONS: Adverse effects of secondary hyperparathyroidism on LV function and structure in this study shows the role of excess PTH in the development of left ventricular hypertrophy as well as low LV ejection fraction. In patients with end-stage renal disease under hemodialysis, more attention needs to be given to the control of secondary hyperparathyroidism to reduce the risk of cardiovascular morbidity and mortality in dialysis patients.

Adult↗

PubMed2004

Correlation of serum magnesium with dyslipidemia in maintenance hemodialysis patients.

One of the factors involved in accelerated atherosclerosis in hemodialysis patients is dyslipidemia. In this study we considered factors involved in intensification of dyslipidemia in hemodialysis patients. This study was done on 36 maintenance hemodialysis patients. Serum lipoprotein (a), Triglyceride, Cholesterol, HDL-C,LDL-C and also serum Intact parathormone(iPTH), Calcium, Phosphorus, Magnesium were measured. In statistical analysis there was not any correlation between serum lipids and iPTH. There was not correlation between serum calcium with serum lipids (p > 0.05). There was not correlation between CaxP product with serum lipids (p > 0.05). There was a positive correlation between serum Magnesium and Lipoprotein(a) (P < 0.05) and also positive correlation between serum magnesium with triglyceride level (P < 0.05) was seen too. Magnesium doesn't increase the lipoprotein synthesis. It may involve in the regulation of some enzymes responsible for lipoprotein synthesis. Correlation of serum magnesium with serum triglycerides can be due to changes in hepatic triglyceride metabolism. Lipoprotein(a) is a non traditional factor of premature atherosclerosis, its association with serum magnesium needs more attention in hemodialysis patients.

Female↗

PubMedDate not supplied

Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis.

BACKGROUND: Cardiovascular risk factors are a significant burden in end-stage renal disease patients under hemodialysis and are the leading cause of death among these patients. The influence of parathyroid hormone (PTH) on myocardial function as a toxin of uremia is under more attention and evaluation because of growing evidence showing that the effects of PTH on cardiac function may be the most serious consequence of secondary hyperparathyroidism in renal failure. In this study we determined role of excess PTH in the development of left ventricular (LV) hypertrophy as well as LV ejection fraction in patients with end-stage renal disease under regular hemodialysis. METHODS: This study is cross-sectional that was done on patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis treatment. For patients, Calcium, Phosphorus, Alkaline phosphatase and Intact PTH (iPTH) were measured. Hypertensive patients were stratified into stages one to three. Echocardiographies for LV hypertrophy and ejection fraction (%) were done and patients stratified into normal, mild, moderate and severe LV hypertrophy. RESULTS: The total patients were 73 (F=28 M=45), consisting of 58 non diabetic hemodialysis patients (F=22 M=36), and 15 diabetic hemodialysis patients (F=6 M=9). The mean age was 46.5+/-16 years. The time on hemodialysis was 21.5+/-23.5 months. The LV ejection fraction (EF%) were 51+/-8 percent. 'iPTH' of patients was 309+/-349 pg/ml. 'iPTH' of diabetic and nondiabetic groups was 234+/-265 pg/ml and 329+/-368 pg/ml respectively. Serum alkaline phosphatase was 413+/-348 IU/L. Serum alkaline phosphatase of diabetic and nondiabetic groups were 295+/-179 IU/L and 443+/-375 IU/L respectively. Serum albumin was 4+/-0.75 g/dl. Serum albumin of diabetic and nondiabetic groups was 3.6+/-0.7 g/dl and 4.2+/-0.7 g/dl respectively. Significant inverse correlation of serum ALP with percent of LV ejection fraction and marginal positive correlation of serum ALP with LVH and also marginal correlation of serum iPTH with LVH were seen. Also significant inverse correlation between serum iPTH with percent of LV ejection fraction in non diabetic heart patients was observed. CONCLUSIONS: Adverse effects of secondary hyperparathyroidism on LV function and structure in this study show the role of excess PTH in the development of left ventricular (LV) hypertrophy as well as low LV ejection fraction in patients with end-stage renal disease under hemodialysis which needs more attention to control of secondary hyperparathyroidism to reduce the risk of cardiovascular morbidity and mortality in dialysis patients.

Adolescent↗

PubMedDate not supplied

Association between white blood cell count and levels of serum homocysteine in end-stage renal failure patients treating with hemodialysis.

BACKGROUND: In hemodialysis patients, plasma levels of total homocysteine are influenced by nutritional status in patients with chronic kidney disease. To investigate the association between serum homocysteine (Hcy) level as a marker of nutritional status and WBC counts as a marker of inflammation, a cross-sectional study was conducted on patients with end-stage renal disease (ESRD), who were undergoing maintenance hemodialysis treatment. METHODS: Serum homocysteine (total) and WBC count were measured. Other biochemical analysis including serum predialysis creatinine (Creat). post and predialysis blood urea nitrogen (BUN), al bumin (Alb), serum C-reactive protein (CRP) and serum ferritin were measured, also intact serum PTH (iPTH) and plasma HCO3 was measured too. For the efficacy of hemodialysis the urea reduction rate (URR) was calculated from pre- and post-blood urea nitrogen (BUN) data. The body mass index (BMI) was also calculated. For correlations the partial correlation test was used. RESULTS: Total patients were 36 (f=15 m=21), consisting of 25 non-diabetic HD patients and 11 diabetic HD patients. The mean patient's age was 47 +/- 17 years. In all patients a significant inverse correlation of serum homocysteine with WBC count and a significant positive correlation of serum Homocysteine with BMI and a near significant positive correlation of WBC count with serum CRP were found. CONCLUSION: In hemodialysis patients an inverse correlation between WBC count as a marker of inflammation with serum Hcy level as a marker of nutritional status, further support the hypothesis of the malnutrition-inflammation cachexia syndrome

Adult↗