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Hamisu M Salihu

Publications and source records attributed to Hamisu M Salihu.

At least 19 recordsLinked to original sources

Systematic review on genomic insights into antimicrobial resistance in ESKAPE pathogens.

BACKGROUND: Antimicrobial resistance (AMR) is a major global public health threat. ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pose a major threat owing to resistance to last-line antibiotics. Genomic surveillance is crucial to understanding global and regional antimicrobial resistance genes (ARGs) in AMR transmission. AIM: This systematic review synthesised global genomic evidence to identify global and region-specific ARGs distribution among ESKAPE pathogens. METHODS: Following PRISMA guidelines, studies published January 2019 to December 2024 were identified from PubMed, Google Scholar, and Web of Science. Eligible studies reported genomic characteristics and resistance patterns of one or more ESKAPE pathogens from any source. RESULTS: Seventy-seven studies were included, with most originating from Asia, followed by Europe and Africa. Clinical isolates predominated K. pneumoniae was the most frequently investigated pathogen, followed by S. aureus, P. aeruginosa, and A. baumannii. The most reported resistance genes were blaCTX-M, blaNDM, and blaSHV. Distinct regional patterns of antimicrobial resistance gene (ARG) distribution were observed, with tetracycline and quinolone resistance genes prevailing in Africa and South America, and blaOXA variants dominating in Asia and Europe. Region-specific ARG patterns were identified through descriptive synthesis and comparative analysis of study-reported frequencies. CONCLUSION: This review provides a synthesised global map of ARG distribution in ESKAPE pathogens, highlighting surveillance gaps in underrepresented regions and non-clinical settings. Addressing these gaps will support targeted genomic surveillance and stewardship programmes. WHAT THIS STUDY ADDS: This study contributes to the body of knowledge by mapping global and regional antimicrobial resistance gene patterns in ESKAPE pathogens, identifying key surveillance gaps and informing targeted AMR monitoring and stewardship strategies.

ESKAPE pathogens↗

SGA subtypes and mortality risk among singleton births.

OBJECTIVES: To determine whether early mortality (first year of life) risks among small for gestational age (SGA) neonates were similar regardless of SGA subtype based on three chronological classifications (term, preterm and post-term). STUDY DESIGN: Retrospective cohort study on all singleton live births in the United States from 1995 to 1999 inclusive. Adjusted risk estimates were computed from logistic regression models using non-SGA infants as the referent. RESULTS: When SGA infants were compared as a homogeneous entity to non-SGA infants, the risks for infant, neonatal and post-neonatal mortality were significantly greater in SGA infants [AOR (adjusted odds ratio)=3.0, 95% CI (confidence interval)=2.9-3.0 for infant mortality; AOR=3.2, 95% CI=3.1-3.2 for neonatal mortality; and AOR=2.6, 95% CI=2.6-2.7 for post-neonatal mortality]. However, heterogeneity existed in terms of mortality risk thresholds across SGA babies. The most remarkable risk magnitude was observed among preterm SGA infants [infant mortality AOR=13.8, 95% CI=13.6-14.1; neonatal death AOR=17.4, 95% CI=17.0-17.7; and post-neonatal death AOR=7.4, 95% CI=7.1-7.6]. The adjusted odds ratio for term and post-term SGA infants were comparable regardless of the period during infancy, and were much less than those observed for preterm SGA infants. CONCLUSIONS: SGA is a heterogeneous disease in terms of prognosis for survival. Preterm SGA infants bear an extremely high risk for mortality during infancy, and counseling of affected parents should reflect this risk divergence.

Cohort Studies↗

Fetal growth risk curves: defining levels of fetal growth restriction by neonatal death risk.

OBJECTIVE: We developed a fetal growth risk curve that delineates the birth weight values for gestational age that reflect a 2-, 2.5-, and 3-fold neonatal death risk relative to infants with normal fetal growth. STUDY DESIGN: We analyzed 18,085,052 single gestation infants (25-42 weeks) who were born to US resident mothers from 1996 to 2000. Multivariate models were used to predict the relationship between neonatal death and birth weight percentile. Fetal risk curves were derived on the basis of birth weight percentile-specific neonatal mortality rates that were relative to an average rate of neonatal death for a comparison group that was representative of typical growth (ie, infants between 45th-55th birth weight percentiles for gestational age). RESULTS: The 10th percentile of birth weight for gestational age is associated with an increased but variable risk of neonatal death relative to the comparison group across the spectrum of gestational ages. At 26 weeks of gestation, infants at the 10th percentile experienced a 3-fold risk of dying within the first 28 days of life (relative to the comparison group); whereas at 40 weeks, the risk was 1.13. CONCLUSION: Fetal growth risk curves facilitate the identification of populations of infants whose risk of death are deemed excessive compared with that of infants at the norm of fetal growth and may be useful for counseling pregnant women.

Birth Weight↗

A method for quantifying birthweight discordance in quadruplets and potential use in predicting early mortality.

We describe an approach to quantify birthweight discordance in quadruplets and assessed its potential use in predicting infant mortality. Retrospective cohort study on quadruplets delivered in the United States from 1995 through 2000 inclusive. The main outcome measures were infant, neonatal, and postneonatal mortality. A total of 2692 quadruplet live births (673 complete clusters) with complete information on gestational age, birthweight, and survival within the first year. Of the total 673 quadruplet clusters, discordance occurred in 180 sets (26.7%). The predominant discordant type was a single discordant individual within a cluster (177 sets or 99.8%), whereas only three sets (0.2%) recorded up to two discordant quadruplets within a cluster. The period of pronounced risk for the occurrence of birthweight discordance was between 28 and 35 gestational weeks. Discordant individuals exhibited elevated risk for infant (adjusted odds ratio [aOR] = 2.1; 95% confidence interval [CI], 1.4 to 3.0), neonatal (aOR = 1.8; 95% CI, 1.2 to 2.6), and postneonatal (aOR = 2.9; 95% CI, 1.1 to 8.4) mortality. After adjusting for small for gestational age, the risk for postneonatal mortality among discordant infants quadrupled (aOR = 4.1; 95% CI, 1.5 to 10.8). The population-attributable risks were 18, 20, and 46% for neonatal, infant, and postneonatal mortality, respectively. The new method is predictive of mortality at all stages of infancy. Discordance accounts for 18 to 46% of all quadruplet deaths during infancy in the United States.

Adult↗

Use of postpartum health services in rural Uganda: knowledge, attitudes, and barriers.

The purpose of this study was to explore the knowledge, attitudes and barriers to use of postpartum care service among rural communities in Uganda. Study was a part of a larger reproductive health evaluation project, and was cross-sectional in nature utilizing qualitative research methods using the narrative inquiry. Two matched rural communities were used in this study; Semuto in Luwero district, and Lwamaggwa in Rakai district. Fifty key informants who were purposefully selected from each study site were interviewed. They included community leaders, political leaders, health care providers, women leaders and community members. One-on-one interviews were conducted with key community informants using an interview guide. The purpose of the interview was explained to each participant, and written informed consent was obtained before the start of the interview. Respondents were allowed to express their views, opinions and observations on several health issues including postpartum health care services. There was a low level of knowledge about postpartum care services among the respondents of the two communities. There was lack of awareness about postpartum care and it's benefits. The main barriers to use of services were; misconceptions regarding the importance of postpartum care, distance to health facilities, poverty, and health system factors notably; poor facilities, lack of essential drugs, and poor attitudes of health workers. In the effort to improve reproductive health care services, there is an urgent need to improve postpartum services, and make them more accessible and user friendly. The training of providers at all levels is essential, in addition to educating families on the importance of postpartum care services.

Adolescent↗

Recurrence of spontaneous versus medically indicated preterm birth.

OBJECTIVE: Despite the increased tendency of preterm birth to recur, little is known with regard to recurrence risks for spontaneous and medically indicated preterm birth as well as recurrence risks in relation to severity of preterm birth. We examined the recurrence of spontaneous and medically indicated preterm birth. STUDY DESIGN: A population-based, retrospective cohort study of births in Missouri (1989 to 1997) was carried out with analyses restricted to women who delivered their first 2 consecutive singleton live births (n = 154,809). Women who experienced spontaneous onset of labor and subsequently delivered preterm (less than 35 weeks) were classified as spontaneous preterm birth. Medically indicated preterm birth included women who delivered preterm through a labor induction or a prelabor cesarean delivery. Risk and odds ratio of preterm birth recurrence were derived from fitting multivariate conditional logistic regression models after adjusting for potential confounders. RESULTS: If the first pregnancy resulted in a spontaneous preterm birth, then affected women were more likely to deliver preterm spontaneously (adjusted odds ratio 3.6, 95% confidence interval 3.2, 4.0) and also as a medically indicated preterm birth (odds ratio 2.5, 95% confidence interval 2.1, 3.0) in the second birth. Similarly, if the first pregnancy resulted in a medically indicated preterm birth, affected women were 10.6-fold (95% confidence interval 10.1, 12.4) more likely to deliver preterm because of medical indications in the second pregnancy as well as preterm spontaneously (odds ratio 1.6, 95% confidence interval 1.3, 2.1). The greatest risk of recurrence of preterm birth in the second pregnancy tended to occur around the same gestational age as preterm birth in the first pregnancy, regardless of the clinical subtype. CONCLUSION: The observation that spontaneous preterm birth is not only associated with increased recurrence of spontaneous but also medically indicated preterm birth and vice versa, suggests that the 2 clinical subtypes may share common etiologies.

Adult↗

Childhood pregnancy (10-14 years old) and risk of stillbirth in singletons and twins.

OBJECTIVE: To clarify the association between childhood pregnancy and risk of stillbirth. STUDY DESIGN: We analyzed singleton and twin pregnancies that occurred in children (10-14 years old) in the United States from 1989 to 2000. We estimated the absolute and relative risks of stillbirth by using 15- to19-year-old and 20- to 24-year-old mothers as comparison groups. RESULTS: The analysis involved 17.8 million singletons and 337,904 individual twins. The rate of stillbirth was highest in pediatric mothers for both singletons (12.8/1000) and twins (56/1000) compared with adolescent (6.8/1000 in singletons and 29/1000 in twins) and mature (5.5/1000 in singletons and 20/1000 in twins) mothers. After adjusting for confounding characteristics, pediatric mothers continued to exhibit significantly elevated risk for stillbirth in both singletons (odds ratio, 1.57; 95%CI, 1.49-1.66) and twins (odds ratio, 1.97; 95%CI, 1.42-2.73). Preterm birth rather than small size for gestational age was revealed by means of sequential modeling to account for the excess risk of stillbirth observed in pediatric gravidas. CONCLUSION: Pregnancy in childhood is a risk factor for stillbirth; shortened gestation rather than reduction in fetal growth is the mediating pathway.

Adolescent↗

Risk of stillbirth following a cesarean delivery: black-white disparity.

OBJECTIVE: We examine the association between prior cesarean delivery and risk of stillbirth in a subsequent pregnancy. METHODS: The Missouri maternally linked cohort data set containing births from 1978 through 1997 was used. We identified a cohort of women who delivered live births by cesarean delivery and a comparison cohort of women who delivered live births vaginally in their first pregnancies. We then compared the risks of stillbirth in the second pregnancy between the 2 groups. RESULTS: We analyzed 396,441 women with information on first and second pregnancies, comprising 71,950 (18.1%) in the cesarean arm, and 324,491 (81.9%) in the vaginal birth arm. Rates of stillbirth among women with and those without history of cesarean delivery were 4.4 and 4.1 per 1,000 births, respectively (P = .2). The adjusted estimates also showed no difference in risk for stillbirth between the 2 groups (odds ratio [OR] 1.1, 95% confidence interval [CI] 1.0-1.3). Among whites, the stillbirth rates in women with and those without history of cesarean delivery were 3.7 and 3.6 per 1,000 births, respectively (OR 1.0, 95% CI 0.9-1.2). Among blacks, both the absolute and the adjusted relative risks for stillbirth were elevated in mothers with history of cesarean delivery (stillbirth rate 9.3 versus 6.8 per 1,000 births; OR 1.4, 95% CI 1.1-1.7). CONCLUSION: Overall, our analysis did not detect an association between cesarean history and subsequent stillbirth. However, cesarean delivery may increase the risk for subsequent stillbirth among black mothers, a group with the highest cesarean delivery rate in the country. LEVEL OF EVIDENCE: III.

Adult↗

Is race a determinant of stillbirth recurrence?

BACKGROUND: A history of stillbirth may result in an increased risk for recurrence, although information regarding this remains scanty. It is also uncertain whether race is a determinant of stillbirth recurrence given that the risk of stillbirth varies across racial and ethnic populations. METHODS: The Missouri maternally linked cohort data set containing births from 1978 through 1997 was used. We identified the study group (women who experienced a stillbirth in the first pregnancy) and a comparison group (women who delivered a live birth in their first pregnancy) and compared the outcome (stillbirth) in the second pregnancy between the 2 groups. RESULTS: We analyzed 404,180 women with information on first and second pregnancies (1,979 [0.5%] in the study arm, and 402,201 [99.5%] in the comparison arm). Of the 1,929 cases of stillbirths in the second pregnancy, 45 cases occurred in mothers with a history of stillbirth (stillbirth rate = 22.7/1000) and 1,884 in the comparison group (stillbirth rate 4.7/1,000, P < .001). The adjusted risk of stillbirth was almost 5-fold as high in women with a prior stillbirth (odds ratio 4.7, 95% confidence interval 3.3-6.6). Analysis across racial groups revealed that whites had lower absolute risk for stillbirth recurrence than African Americans (19.1/1,000 compared with 35.9/1,000, P < .05). The elevated stillbirth recurrence risk was confirmed after adjusting for potential confounders (odds ratio 2.6, 95% confidence interval 1.2-5.7). CONCLUSION: History of stillbirth is associated with a 5-fold increase for subsequent stillbirth. The recurrence of stillbirth is almost tripled in African Americans as compared with whites. LEVEL OF EVIDENCE: II-2.

Adult↗

Previous cesarean delivery and risks of placenta previa and placental abruption.

OBJECTIVE: To examine the association between cesarean delivery and previa and abruption in subsequent pregnancies. METHODS: A retrospective cohort study of first 2 (n = 156,475) and first 3 (n = 31,102) consecutive singleton pregnancies using the 1989-1997 Missouri longitudinally linked data were performed. Relative risk (RR) was used to quantify the associations between cesarean delivery and risks of previa and abruption in subsequent pregnancies, after adjusting for several confounders. RESULTS: Rates of previa and abruption were 4.4 (n = 694) and 7.9 (n = 1,243) per 1,000 births, respectively. The pregnancy after a cesarean delivery was associated with increased risk of previa (0.63%) compared with a vaginal delivery (0.38%, RR 1.5, 95% confidence interval [CI] 1.3-1.8). Cesarean delivery in the first and second births conferred a two-fold increased risk of previa in the third pregnancy (RR 2.0, 95% CI 1.3-3.0) compared with first two vaginal deliveries. Women with a cesarean first birth were more likely to have an abruption in the second pregnancy (0.95%) compared with women who had a vaginal first birth (0.74%, RR 1.3, 95% CI 1.2-1.5). Two consecutive cesarean deliveries were associated with a 30% increased risk of abruption in the third pregnancy (RR 1.3, 95% CI 1.0-1.8). A second pregnancy within a year after a cesarean delivery was associated with increased risks of previa (RR 1.7, 95% CI 0.9-3.1) and abruption (RR 1.5, 95% CI 1.1-2.3). CONCLUSION: A cesarean first birth is associated with increased risks of previa and abruption in the second pregnancy. There is a dose-response pattern in the risk of previa, with increasing number of prior cesarean deliveries. A short interpregnancy interval is associated with increased risks of previa and abruption. LEVEL OF EVIDENCE: II-2.

Abruptio Placentae↗

Is small for gestational age a marker of future fetal survival in utero?

OBJECTIVE: We sought to assess whether small for gestational age is a risk factor for stillbirth of a subsequent sibling. METHODS: The Missouri maternally linked cohort data set, containing data on births from 1978 through 1997, was used. We identified the study group (women who delivered a SGA infant in the first pregnancy) and a comparison group (women who delivered a non-SGA infant in their first pregnancy) and compared the outcome (stillbirth) in the second pregnancy between both groups. RESULTS: We analyzed information on the first and second pregnancies of 402,015 women (43,549 [10.8%] in the study arm and 358,466 [89.2%] in the comparison arm). Of the 1,883 cases of stillbirth in the second pregnancy, 314 cases occurred in mothers with a history of SGA (stillbirth rate 7.2/1,000) and 1,569 in the comparison group (stillbirth rate 4.4/1,000), P < .001. The adjusted risk of stillbirth was 60% higher in women with a prior SGA (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.4-1.8). The risk for stillbirth in the second pregnancy increased with decreasing gestational age at birth of the SGA infant in the first pregnancy (term: OR 1.4, 95% CI 1.2-1.6; preterm: OR 2.8, 95% CI 2.0-3.8; and very preterm: OR 4.2, 95% CI 2.4-7.3), P for trend < .001. CONCLUSION: Small for gestational age is a marker for subsequent stillbirth, and the risk rises with decreasing gestational age of the SGA birth. This information is potentially useful for counseling parents of SGA infants. LEVEL OF EVIDENCE: II-2.

Adult↗

Impact of anomalous triplets on morbidity outcomes of normal in utero siblings.

OBJECTIVE: To evaluate the impact of number of anomalous fetuses on the prevalence of very preterm births (< 32 weeks), very low birth weight (< 1,500 g), and small for gestational age (SGA) infants among their normal cotriplets. METHODS: Cross-sectional study of United States triplet births from 1995 to 2000 using Matched Multiple Birth Files, comparing outcomes for triplet sets with no anomalous, 1 anomalous, and 2 anomalous fetuses. Chi-square test for trend and multiple logistic regression analyses, applying generalized estimating equations to account for correlation among cotriplets, were implemented. RESULTS: Of 34,881 matched triplets, 34,104 (97.8%) were nonanomalous (2.2% prevalence of fetal anomaly). Prevalence of very preterm birth (P < .001) and very low birth weight (P < .001), but not SGA (P = .52), among nonanomalous births increased significantly with number of anomalous cotriplets. The prevalence of very preterm birth was 44.1%, 54.8%, and 68.8%, respectively, as number of anomalous triplets per set increased from none to two. The prevalence of very low birth weight was 32.3%, 39.6%, and 62.0%, respectively. These trends remained unchanged after adjustment for correlation and potential confounding. CONCLUSION: Prevalence of triplet births with gestation less than 32 weeks and birth weight less than 1,500 g, but not SGA, among nonanomalous triplets increase linearly with number of anomalous members within triplet sets. LEVEL OF EVIDENCE: III.

Adult↗

Back to the future? A critical commentary on the 2003 U.S. National standard certificate of live birth.

Vital statistics documents for the United States have been revised approximately decennially throughout the past century. In this commentary we review the contents of the 2003 revision of the national standard certificate of live birth, focusing on changes from the certificates in use nationally since 1989, and identifying strengths and weaknesses of key data elements. Additional federal-state partnership funding is imperative to support the transition to the new standard certificates, and to ensure a focus on data quality at the state and national levels.

Adult↗

Mode of delivery and the survival of macrosomic infants in the United States, 1995-1999.

BACKGROUND: Although increases in perinatal mortality risk associated with fetal macrosomia are well documented, the optimal route of delivery for fetuses with suspected macrosomia remains controversial. The objective of this investigation was to assess the risk of neonatal death among macrosomic infants delivered vaginally compared with those delivered by cesarean section. METHODS: Data were derived from the U.S. 1995-1999 Linked Live Birth-Infant Death Cohort files and term (37-44 wk), single live births to United States resident mothers selected. A proportional hazards model was used to analyze the risk of neonatal death associated with cesarean delivery among 3 categories of macrosomic infants (infants weighing 4,000-4,499 g; 4,500-4,999 g; and 5,000+ g). RESULTS: After controlling for maternal characteristics and complications, the adjusted hazard ratio for neonatal death associated with cesarean delivery among the 3 categories of macrosomic infants was 1.40, 1.30, and 0.85. CONCLUSIONS: Although cesarean delivery may reduce the risk of death for the heaviest infants (5,000+ g), the relative benefit of this intervention for macrosomic infants weighing 4,000-4,999 g remains debatable. Thus, policies in support of prophylactic cesarean delivery for suspected fetal macrosomia may need to be reevaluated.

Cesarean Section↗

The association between small-for-gestational age triplet pregnancies and neonatal mortality: a novel approach to growth assessment in multiple gestations.

It is customary to estimate the uteroplacental function in singletons by defining appropriateness of birth weight by gestational age. Such a measure, however, is not available for the entire multiple pregnancy set. We evaluate a new index, total triplet birth weight, expressed as multiples of the median (MOM) birth weight of singleton gestations. We categorized triplet sets as small-, appropriate-, and large-for-gestational age pregnancies (SGA, AGA, and LGA, respectively), defined as <1 SD, +/-1 SD, and >1 SD from the mean MOM birth weight of singleton gestations. We used the 1995-1998 US matched multiple dataset to evaluate this index and to explore the association between the three categories in terms of risk of neonatal mortality. The mean +/- SD MOM value was 2.3 +/- 0.4. There was an inverse correlation between mean MOM and gestational age. LGA pregnancy status was associated with multiparity, race (being white), and high social status (education). Maternal age did not influence MOM scores. Compared with the LGA pregnancy category, the risk for neonatal mortality was more than doubled in the AGA pregnancy group and more than 9-fold in the SGA pregnancy category. We propose that this new measure could be a useful proxy for the uteroplacental efficiency in a similar way that the SGA designation works for singleton infants.

Adult↗

Twinning and risk of stillbirth subtypes in pediatric mothers.

We sought to estimate levels of risk for stillbirth subtypes associated with twin gestations among pediatric mothers (10-14 years). Analysis was on twin pregnancies covering the period 1989 to 2000 in the United States. We classified stillbirth as term, preterm, small-for-gestational-age (SGA) or preterm-SGA. We then assessed the risks of these stillbirth subtypes in pediatric mothers using two comparison groups consisting of women aged 15 to 19 years old (adolescent mothers) and 20 to 24 years old (mature mothers). Adjusted risk estimates were by means of hazard ratios generated from a Cox proportional hazards regression model. We adjusted for dependence of observations within twin clusters using the robust sandwich estimator. The rate of stillbirth was highest among pediatric mothers (56/1000), followed by adolescent gravidas (29/1000) and lowest in mature mothers (20/1000; p for trend < .01). Overall, preterm stillbirth was the most frequent stillbirth phenotype while term stillbirth was the least frequent. Not a single case of term stillbirth was recorded in pediatric mothers. Among pediatric gravidas, the risk for preterm stillbirth was more than tripled (adjusted hazard ratio [AHR] = 3.4; 95% confidence interval [CI] = 2.5-4.6), and that of preterm-SGA stillbirth more than doubled (AHR = 2.6; 95% CI = 1.8-3.7) that of mature mothers respectively. The 30% risk elevation for SGA stillbirth among pediatric mothers was not found to be statistically significant (AHR = 1.1; 95% CI = 0.3-4.3). Pediatric motherhood is a risk factor for stillbirth in twin gestation, especially, preterm and preterm-SGA stillbirth phenotypes. Prevention of stillbirth among this category of mothers should target the period preceding full term.

Adolescent↗

First-time births among women 30 years and older in the United States: patterns and risk of adverse outcomes.

OBJECTIVE: To update the trends in initiation of childbirth by age of the mother, describing the characteristics of women having their first child at age 30 or above, and to determine the risk for adverse pregnancy outcomes for this group of women. STUDY DESIGN: This was a cross-sectional study using National Center for Health Statistics linked live birth and infant death cohort files from 1995 to 2000, and Natality file from 1980 to 2002. Analysis was limited to index pregnancies only. Logistic regression analysis was used to determine the risk of poor outcomes. RESULTS: There is a decreasing trend of first-time births to women 20-29 years old, while births to women 30 and older are showing a continued rise. As compared to 20-29-year-olds, women who start childbearing at age 30 or older are at increased risk of maternal complications in general. However, 30-34-year-olds have a reduced risk for pregnancy-induced hypertension and pre-existing hypertension. Infants born to women aged 30 and above are at increased risk for prematurity and low birth weight in addition to fetal and infant mortality. CONCLUSION: Because of the increasing trend of women starting childbearing in their 30s and the increased risk for poor outcomes in older women, health providers need to pay extra attention to this group of women as they plan and deliver services for them.

Adult↗