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Hao-zhu Chen

Publications and source records attributed to Hao-zhu Chen.

8 recordsLinked to original sources
PubMed2006

Assessment of left ventricular systolic synchronicity by real-time three-dimensional echocardiography in patients with dilated cardiomyopathy.

BACKGROUND: Recent advances in real-time three-dimensional echocardiography (RT3DE) offer the potential to assess the left ventricular (LV) dyssynchrony simultaneously by analyzing the 17 segments time-volume curves. The purpose of this study was to test the feasibility and accuracy of RT3DE for quantitative evaluation of left ventricular systolic synchronicity. METHODS: Twenty-four patients with dilated cardiomyopathy (DCM) and twenty-five healthy volunteers were enrolled in this study. Full volume RT3DE was performed by using Philips IE33 with X3-1 probe. The global and 17-segmental time-volume curves were obtained by the on-line Qlab software (version 4.2). The time to minimal systolic volume in each segment (T(msv)) was taken to derive the following indexes of systolic asynchrony: T(msv) 16-SD, T(msv) 16-Dif, T(msv) 12-SD, T(msv) 12-Dif, T(msv) 6-SD and T(msv) 6-Dif, which meant the standard deviation or the maximal difference of T(msv) among the 16, 12 and 6 segments of the left ventricle respectively. The software also provided with each of the above parameters as a percentage of the cardiac cycle. RESULTS: T(msv) 16-SD, T(msv) 12-SD and T(msv) 6-SD were all significantly larger in the DCM group than those of the control group [T(msv) 16-SD: (52.9 +/- 40.6) ms vs (8.8 +/- 6.2) ms; T(msv) 12-SD: (29.5 +/- 30.8) ms vs (6.9 +/- 4.0) ms; T(msv) 6-SD: (28.9 +/- 34.6) ms vs (7.0 +/- 4.7) ms, all P < or = 0.001]. T(msv) 16-Dif, T(msv) 12-Dif and T(msv) 6-Dif were also significantly larger in the DCM group. There were close negative relations between the LVEF determined by RT3DE and each of the indexes of systolic asynchrony, among which the indexes of T(msv)-16-SD% and T(msv)-16-Dif% correlated most closely (r = -0.703 and r = -0.701, respectively). The DCM patients had significantly larger EDV and ESV, with significantly reduced LVEF compared with the healthy subjects. CONCLUSION: RT3DE provides a simple, useful and unique approach to assess the systolic synchronicity of all the left ventricular segments simultaneously.

Adult↗
PubMed2005

Usefulness of dobutamine stress myocardial contrast echocardiography for assessing coronary artery disease.

BACKGROUND: Quantitatively assessing myocardial perfusion and its reserve is of great importance for the diagnosis and stratification of patients with coronary artery disease (CAD), and represents an important goal of myocardial contrast echocardiography. In this study we sought to test the usefulness of low dose dobutamine stress real-time myocardial contrast echocardiography (RT-MCE) in the assessment of CAD, and to explore the relationship between perfusion reserve and contractile reserve. METHODS: Twenty-six patients with suspected or clinical diagnosed CAD were enrolled and underwent RT-MCE at baseline and under low dose dobutamine stress, and subsequent coronary angiography. RT-MCE images were analyzed quantitatively from microbubble replenishment curves for myocardial perfusion and its reserve. RESULTS: At baseline, significant differences in beta (0.28 +/- 0.12, 0.25 +/- 0.09, 0.22 +/- 0.06, 0.20 +/- 0.07 respectively, P < 0.01) and A x beta (1.37 +/- 0.46, 1.28 +/- 0.47, 1.13 +/- 0.37, 0.91 +/- 0.32, respectively, P < 0.01) were observed among four segment groups with graded coronary artery stenosis severity (normal; 30% - 69% stenosis; 70% - 90% stenosis; and beyond 90% stenosis), but not observed in parameter A. When under stress, significant differences in A (5.73 +/- 1.28, 5.63 +/- 1.01, 4.96 +/- 0.81, 4.57 +/- 0.62, respectively, P < 0.01), beta (0.67 +/- 0.17, 0.55 +/- 0.19, 0.32 +/- 0.13, 0.25 +/- 0.08, respectively, P < 0.01) and A x beta (3.81 +/- 1.20, 3.11 +/- 1.17, 1.59 +/- 0.82, 1.12 +/- 0.37, respectively, P < 0.01) were observed among the formerly mentioned groups. Graded decreases in A reserve (1.20 +/- 0.53, 1.11 +/- 0.16, 0.98 +/- 0.12, 0.99 +/- 0.13, respectively, P < 0.01), beta reserve (2.65 +/- 1.07, 2.32 +/- 0.82, 1.44 +/- 0.40, 1.29 +/- 0.34, respectively, P < 0.01) and A x beta reserve (3.05 +/- 1.63, 2.59 +/- 1.01, 1.42 +/- 0.44, 1.27 +/- 0.34, respectively, P < 0.01) could also be observed with increasing coronary stenosis severity. In five segments groups scored by WMS (1 - 5), concordance between contractile function and myocardial perfusion could be found both at rest (beta: 0.28 +/- 0.11, 0.22 +/- 0.08, 0.21 +/- 0.05, 0.17 +/- 0.05, 0.19 +/- 0.06, respectively, P < 0.01; A x beta: 1.29 +/- 0.48, 0.98 +/- 0.45, 0.94 +/- 0.29, 0.76 +/- 0.30, 0.92 +/- 0.32, respectively, P < 0.01) and under stress (beta: 0.59 +/- 0.20, 0.35 +/- 0.15, 0.27 +/- 0.08, 0.17 +/- 0.05, 0.20 +/- 0.05, respectively, P < 0.01; A x beta: 3.07 +/- 1.38, 1.62 +/- 0.82, 1.28 +/- 0.40, 0.78 +/- 0.24, 0.93 +/- 0.22, respectively, P < 0.01). This concordance is also valid in terms of the reserves, and the MCE parameters in segments with ameliorated contractile function are significantly higher than in those without. CONCLUSIONS: Quantitative RT-MCE in conjunction with dobutamine stress shows promise in identifying and stratifying CAD and in exploring the perfusion-contractile correlation.

Adult↗
PubMed2005

[Value of low dose dobutamine real-time myocardial contrast echocardiography in the assessment of coronary artery disease].

OBJECTIVE: To evaluate the value of quantitative real-time myocardial contrast echocardiography (RT-MCE) combined with low dose dobutamine stress test in the detection of coronary artery disease (CAD), and to assess the contribution of collateral blood flow (CBF) to myocardial perfusion. METHODS: Twenty-six hospitalized patients referred for coronary angiography and subsequent revascularization underwent routine echocardiography, RT-MCE at baseline and after low dose dobutamine administration. The images of RT-MCE were analyzed quantitatively from microbubble replenishment curves for myocardial perfusion and its reserve by using the QLab software. RESULTS: At baseline, both beta and A x beta (but not A) were decreased with the increase of severity of coronary stenosis (P < 0.01). Under dobutamine stress, A, beta and A x beta values were decreased with the increase of severity of coronary stenosis (P < 0.01), Graded decreasing in the reserves of A, beta and A x beta were observed with increasing coronary stenosis severity (P < 0.01). Furthermore, significant differences in beta, A x beta, and WMS were observed between segments with CBF and those without. CONCLUSION: Quantitative RT-MCE in conjunction with dobutamine stress can be used as a sensitive measure to identify and stratify CAD as well as to assess the contribution of collateral blood flow.

Adult↗
PubMed2005

[Frequency of the anomalous coronary origin in the Chinese population with coronary artery stenosis].

OBJECTIVE: To estimate the frequency of anomalous coronary origin with angiography in the Chinese population and evaluate the correlation between anomalous coronary origin and development of coronary atherosclerotic stenosis. METHODS: All of the patients who underwent diagnostic coronary angiography from January 2001 to June 2004 were retrospectively reviewed. Those with anomalous origin of the coronary arteries were selected for further assessment and any significant stenosis in one or more coronary arteries or in a major branch was recorded. RESULTS: Among the 4094 patients, 32 (0.78%) had anomalies of coronary origin. Right coronary artery was the most common anomalous vessel, being involved in 21 (65.6%) patients. It originated from the left sinus of Valsalva in 19 and from the non-coronary aortic sinus in 2 patients. Anomalous left circumflex artery was the second most common anomaly, being seen in 5 (15.6%) patients. Anomalous left main coronary artery from the right sinus of Valsalva and anomalous left coronary artery from pulmonary artery were seen in 3 patients, respectively. Significant lesions in the anomalous arteries were seen in only 5 (15.6%) patients, much less than the overall incidence of coronary artery lesion in patients with coronary anomalies in this series (34.3%). Moreover, no patient was found that the anomalous vessel was the only one involved in coronary atherosclerotic stenosis. CONCLUSIONS: The incidence of anomalous coronary origin in Chinese population is almost as same as in other races and an anomalous right coronary artery is the most common anomaly. The anomalous coronary artery does not appear to be of any increased risk for development of coronary atherosclerotic stenosis.

Adolescent↗
PubMed2004

The role of inflammatory stress in acute coronary syndrome.

OBJECTIVE: To summarize current understanding of the roles of anti-inflammatory and proinflammatory mechanisms in the development of atherosclerosis and acute coronary syndrome and to postulate the novel concept of inflammation stress as the most important factor triggering acute coronary syndrome. Moreover, markers of inflammation stress and ways to block involved pathways are elucidated. DATA SOURCES: A literature search (MEDLINE 1997 to 2002) was performed using the key words "inflammation and cardiovascular disease". Relevant book chapters were also reviewed. STUDY SELECTION: Well-controlled, prospective landmark studies and review articles on inflammation and acute coronary syndrome were selected. DATA EXTRACTION: Data and conclusions from the selected articles providing solid evidence to elucidate the mechanisms of inflammation and acute coronary syndrome were extracted and interpreted in the light of our own clinical and basic research. DATA SYNTHESIS: Inflammation is closely linked to atherosclerosis and acute coronary syndrome. Chronic and long-lasting inflammation stress, present both systemically or in the vascular walls, can trigger acute coronary syndrome. CONCLUSIONS: Inflammation stress plays an important role in the process of acute coronary syndrome. Drugs which can modulate the balance of pro- and anti-inflammatory processes and attenuate inflammation stress, such as angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers, statins, and cytokine antagonists may play active roles in the prevention and treatment of acute coronary syndrome when used in addition to conventional therapies (glycoprotein IIb/IIIa receptor antagonists, mechanical intervention strategies, etc).

Angina Pectoris↗
PubMed2004

Microarray analysis of extracellular matrix genes expression in myocardium of mouse with Coxsackie virus B3 myocarditis.

BACKGROUND: Extracellular matrix (ECM) orchestrates cell behaviour including growth, death, apoptosis, adhesion, migration, and invasion by activating several signalling pathways. Certain components of ECM, such as integrins, may act as receptors or co-receptors of enterovirus. ECM-activated gene expressions in myocardium of viral heart disease including myocarditis and partial cardiomyopathy remain elusive. This study was to investigate the expression of ECM-activated genes in myocardium of mouse with viral myocarditis. METHODS: BALB/c mice were infected with Coxsackie virus B3 (CVB3) to establish an animal model of myocarditis. Uninfected mice were also prepared and served as controls. Specific mRNA expression pattern in myocarditic mouse heart was analysed by an in-house cDNA microarray containing 8,192 genes. Overexpressed ECM genes were selected and subsequently confirmed by Northern blot analysis. RESULTS: Nine ECM genes were isolated, from the array of 8,192 genes, as overexpressed genes in hearts of myocarditic mice in comparison with controls. Subsequent Northern blot analysis confirmed that four of the nine genes were highly expressed. Expression of these four genes, Fin15, ILk, Lamr1 and ADAMTS-1, has not been reported previously to be induced by Coxsackie virus. CONCLUSION: CVB3-induced myocarditis is associated with gene expression profiles of certain ECM components.

Animals↗
PubMed2003

[Changing trends of etiologic characteristics of cardiovascular diseases among inpatients in Shanghai: a retrospective observational study from 1948 to 1999].

OBJECTIVE: To investigate the trends in the change of etiologic types of cardiovascular disease among inpatients in Shanghai area from 1948 to 1999. METHODS: The retrospective estimate was based on the data survey in two major general hospitals of Shanghai. Descriptive statistics were provided for all patients meeting the inclusion criteria. Trend of percentage change was compared using linear regression. Diagnoses were categorized using the International Classification of Diseases, 9th Revision. RESULTS: (1) A total of 37 086 admissions with different etiologic types of heart diseases from 1948 to 1999 was reviewed. The percentage of heart diseases among the inpatients in medical wards was significantly increased during this period, being 9.89%, 15.69%, 20.91%, 23.54% and 24.24% (P < 0.05) for each decade respectively and reaching a peak in 1990s. (2) Patterns of different etiologic types of heart diseases changed markedly from 1948 to 1999. The percentage of coronary heart disease increased from 6.78% in 1940s to 39.19% in 1990s (P < 0.05), cardiac dysrhythmias from 0.63% to 18.84% (P < 0.05), cardiomyopathy from 0.05% to 5.01% (P < 0.05) and endocarditis from 0.02% to 0.69% (P < 0.05). The percentage of rheumatic heart disease decreased from 50.30% to 10.25% (P < 0.05). The percentage of hypertensive heart disease, myocarditis and congenital heart disease remained unchanged. (3) From 1948 to 1999 the overall in-hospital mortality of heart diseases in different decades decreased from 17.91%, 11.51%, 14.07%, 7.35% to 2.39% (P < 0.05). (4) Patients were slightly younger in 1950s (39.7 +/- 5.5) years than those in 1990s (60.1 +/- 12.7) years (P < 0.05). (5) The percentage of male patients increased (ranging from 50.7% in 1940s to 62.4% in 1990s, P < 0.05). CONCLUSIONS: Hospitalization patterns of heart diseases have changed dramatically in the second half of the last century in Shanghai. Coronary heart disease is the most frequent condition requiring hospitalization nowadays and the rates of many age-related heart diseases are increasing and this has been paralleled by a substantial increase of the rates in the community survey. More attention should be paid to these heart diseases in Shanghai and in this century.

Adult↗