Biomedical subjects

Hayato Ikota

Publications and source records attributed to Hayato Ikota.

4 recordsLinked to original sources

PubMed2006

Xanthogranulomatous cholangitis causing obstructive jaundice: a case report.

This article reports the case of a 34-year-old woman with xanthogranulomatous cholangitis who developed obstructive jaundice. Microscopically, the bile duct was surrounded and narrowed by a xanthogranulomatous lesion, but no xanthogranulomatous cholecystitis was seen. Although percutaneous cholangiograms done via the transhepatic biliary drainage showed smooth narrowing of the upper to middle bile duct, the cytology of bile was diagnosed as class V adenocarcinoma. Therefore, right extended hepatectomy and extrahepatic bile duct resection were performed. The differentiation of benign and malignant strictures at the hepatic hilum is often difficult. Xanthogranulomatous cholangitis is one possible diagnosis of a bile duct stricture. Precise review of all the preoperative information is required to make a correct diagnosis.

Adenocarcinoma↗

PubMed2006

Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology.

We performed a systematic immunohistochemical study on 378 brain tumors using 37 antibodies and tissue microarray (TMA) technology. The aim of this study was to find new diagnostic biomarkers using antibodies established in our laboratory. Our TMA consisted of a grid of 1.5-mm cores that were extracted from individual donor blocks. Staining for each antibody was scored using a three-point system. We used hierarchical clustering analysis to interpret these data, which resulted in separation of all the brain tumors into seven groups. Although there were some exceptions, cases with the same histological diagnosis were generally grouped together. We then carried out statistical analyses to find the most useful antibodies for grouping of brain tumors. Ten antibodies [glial fibrillary acidic protein (GFAP), Olig2, vimentin, epithelial membrane antigen (EMA), cytokeratin (AE1/AE3), alpha-internexin, nestin, pinealocytes PP5, aquaporin-4 (AQP4) M13d and AQP4M13e] discriminated between astrocytomas and oligodendroglial tumors. Six antibodies [EMA, AE1/AE3, TUJ1, nestin, neurofilament protein-MH (NF-MH) and perivascular cells GP-1] showed significant differences between high-grade and low-grade gliomas. Our data have revealed new antibodies with potential diagnostic utility (Olig2, PP5, GP-1) and demonstrate that TMA technology is highly useful for evaluating newly established antibodies in brain-tumor research.

Antibodies↗

PubMed2005

Endometrioid adenocarcinoma arising from endometriosis of the mesenterium of the sigmoid colon.

This report presents a case of endometrioid adenocarcinoma arising from endometriosis of the mesenterium of the sigmoid colon following total abdominal hysterectomy and bilateral salpingo-oophorectomy for leiomyoma of the uterus and infiltrating pelvic endometriosis, and hormone replacement therapy. A 62-year-old woman presented with an abdominal tumor. Based on the diagnosis of mesocolonic tumor, sigmoidectomy with lymph node resection was performed. The tumor cells were immunopositive for cytokeratin 7, but negative for cytokeratin 20, and the tumor was histologically diagnosed as endometrioid adenocarcinoma of the mesocolon. Hyperestrogenism has been implicated as a risk factor for the development of cancer from endometriosis. The patient had been receiving high-dose unopposed estrogens for 14 years after a total abdominal hysterectomy and bilateral salpingo-oophorectomy. Physicians should recognize that endometriosis-associated neoplasms are able to cause symptoms or signs such as abdominal and/or pelvic pain, pelvic mass, and vaginal bleeding, especially if the patient has been treated with hormone replacement therapy. It is important to recognize the possibility of tumors arising from endometriosis when evaluating intestinal or mesenteric neoplasms in women, even in the patient who has previously undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy, particularly if the patient has a history of endometriosis and has received hormone replacement therapy.

Carcinoma, Endometrioid↗

PubMed2004

Ureteral leiomyoma causing hydronephrosis in Type 1 multiple endocrine neoplasia.

A rare case of leiomyoma of the ureter in a patient with type 1 multiple endocrine neoplasia (MEN) is reported. The case is of a Japanese man in his forties who had a past history of parathyroid gland hyperplasia, pancreatic islet cell tumors, and bilateral adrenocortical nodular hyperplasia. The leiomyoma, measuring 15 x 13 x 12 mm, was located in the right upper ureter, obstructing the lumen and causing hydronephrosis. Three small leiomyomas were also detected in the lower portion. Furthermore, histological examination revealed three tiny leiomyomatous nodules embedded in the muscular layer. It has been reported that type 1 MEN is often complicated by multiple leiomyoma in many organs, including the esophagus, stomach, lung, uterus, and skin. However, it is believed that this is the first report of leiomyomatosis of the ureter occurring in a patient with type 1 MEN. It should be recognized that multiple ureteral leiomyomas may develop in patients of type 1 MEN and can potentially result in hydronephrosis. The multiple development of leiomyoma suggests a causal relationship to MEN1 gene alteration.

Adult↗