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Heather Tye

Publications and source records attributed to Heather Tye.

6 recordsLinked to original sources
PubMed2006

Minimisation of palladium content in Suzuki cross-coupling reactions.

A protocol for conducting Suzuki reactions in a plate format amenable to use in library synthesis of biaryl compounds has been developed. A key objective was to determine reaction conditions which give biaryl products containing <10 ppm of Pd for a wide variety of building blocks. A Design of Experiments (DoE) approach for the identification of an optimised set of reaction conditions was successfully applied. The utility of the protocol developed has been demonstrated by preparation of an array of 96 biaryl compounds in a parallel fashion.

Catalysis↗
PubMed2004

Application of statistical 'design of experiments' methods in drug discovery.

The use of 'design of experiments' (DoE) is a revolutionary approach to optimisation and screening of experimental parameters. Simple experimental designs and statistical tools for data analysis can provide much information about the system under investigation after only a few experiments. Such information can be key in decision-making for further experiments and can enable the development of robust and reliable protocols for chemical synthesis, analytical methods or biological assays. Coupling of design of experiments with modern high-throughput automation systems has the potential to maximise the capabilities of these systems and give increased productivity for many drug discovery applications.

Biological Assay↗
PubMed2004

Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction.

The utility of a Design of Experiments (DoE) approach for the rapid and efficient optimisation of a microwave assisted Ugi 3cc reaction of levulinic acid is demonstrated. DoE methods have also been applied to the assessment of the reaction scope for a range of amine and isonitrile substrates. The optimal procedure developed using this approach has enabled the preparation of lactam derivatives in moderate to excellent yields (17-90%) in a reaction time of only 30 min compared to the conventional methodology which required up to 48 h.

Journal Article↗
PubMed2004

Microwave-promoted organic synthesis using ionic liquids: a mini review.

Due to their extraordinary properties, such as the ionic composition, good thermal stability, low vapor pressure, and solution interactions, ionic liquids can be used as solvents, reagents, and heating aids in conjunction with microwave chemistry. Synthesis of diverse molecules can be improved with the use of the ionic liquids assisted microwave heating due to fast reaction times, simple reaction work-up, and catalyst recovery. This mini-review outlines this newly emerging field.

Chemistry, Organic↗
PubMed2003

Microwave-assisted Mannich-type three-component reactions.

Mannich-type three-component reactions have been performed successfully using microwave heating in conjunction with the use of ionic liquids as heating agents. Good product yields and short reaction times have been achieved.

Chemistry, Organic↗