Biomedical subjects

Helge Ritter

Publications and source records attributed to Helge Ritter.

9 recordsLinked to original sources

PubMed2006

Large-scale data exploration with the hierarchically growing hyperbolic SOM.

We introduce the Hierarchically Growing Hyperbolic Self-Organizing Map (H2SOM) featuring two extensions of the HSOM (hyperbolic SOM): (i) a hierarchically growing variant that allows for incremental training with an automated adaptation of lattice size to achieve a prescribed quantization error and (ii) an approximate best match search that utilizes the special structure of the hyperbolic lattice to achieve a tremendous speed-up for large map sizes. Using the MNIST and the Reuters-21578 database as benchmark datasets, we show that the H2SOM yields a highly efficient visualization algorithm that combines the virtues of the SOM with extremely rapid training and low quantization and classification errors.

Algorithms↗

PubMed2006

Learning lateral interactions for feature binding and sensory segmentation from prototypic basis interactions.

We present a hybrid learning method bridging the fields of recurrent neural networks, unsupervised Hebbian learning, vector quantization, and supervised learning to implement a sophisticated image and feature segmentation architecture. This architecture is based on the competitive layer model (CLM), a dynamic feature binding model, which is applicable on a wide range of perceptual grouping and segmentation problems. A predefined target segmentation can be achieved as attractor states of this linear threshold recurrent network, if the lateral weights are chosen by Hebbian learning. The weight matrix is given by the correlation matrix of special pattern vectors with a structure dependent on the target labeling. Generalization is achieved by applying vector quantization on pair-wise feature relations, like proximity and similarity, defined by external knowledge. We show the successful application of the method to a number of artifical test examples and a medical image segmentation problem of fluorescence microscope cell images.

Image Processing, Computer-Assisted↗

PubMed2005

Principal surfaces from unsupervised kernel regression.

We propose a nonparametric approach to learning of principal surfaces based on an unsupervised formulation of the Nadaraya-Watson kernel regression estimator. As compared with previous approaches to principal curves and surfaces, the new method offers several advantages: First, it provides a practical solution to the model selection problem because all parameters can be estimated by leave-one-out cross-validation without additional computational cost. In addition, our approach allows for a convenient incorporation of nonlinear spectral methods for parameter initialization, beyond classical initializations based on linear PCA. Furthermore, it shows a simple way to fit principal surfaces in general feature spaces, beyond the usual data space setup. The experimental results illustrate these convenient features on simulated and real data.

Algorithms↗

PubMed2004

BCI Competition 2003--Data set IIb: support vector machines for the P300 speller paradigm.

We propose an approach to analyze data from the P300 speller paradigm using the machine-learning technique support vector machines. In a conservative classification scheme, we found the correct solution after five repetitions. While the classification within the competition is designed for offline analysis, our approach is also well-suited for a real-world online solution: It is fast, requires only 10 electrode positions and demands only a small amount of preprocessing.

Algorithms↗

PubMed2004

Model-free functional MRI analysis using topographic independent component analysis.

Data-driven fMRI analysis techniques include independent component analysis (ICA) and different types of clustering in the temporal domain. Since each of these methods has its particular strengths, it is natural to look for an approach that unifies Kohonen's self-organizing map and ICA. This is given by the topographic independent component analysis. While achieved by a slight modification of the ICA model, it can be at the same time used to define a topographic order (clusters) between the components, and thus has the usual computational advantages associated with topographic maps. In this contribution, we can show that when applied to fMRI analysis it outperforms FastICA.

Algorithms↗

PubMed2004

Data mart based research in heart surgery: challenges and benefit.

For many new medical research questions in heart surgery comprehensive and large data bases are essential. We discuss typical challenges for the integration of real-time and legacy data stored in multiple unconnected hospital information systems (HIS). Furthermore the HIS are often operated by autonomous departments whose data base structures are subject to occasional modifications. We present a solution which integrates and consolidates all research relevant data in a data mart without imposing any considerable operational or maintenance contract liability risk for the existing HIS. The problems of partial consistency and partial redundancy in the data are discussed. The data mart system serves multiple purposes: beside clinical reporting and quality assessment, the preparation steps for comprehensive studies are enormously simplified.

Biomedical Research↗

PubMed2003

Human vs machine: evaluation of fluorescence micrographs.

To enable high-throughput screening of molecular phenotypes, multi-parameter fluorescence microscopy is applied. Object of our study is lymphocytes which invade human tissue. One important basis for our collaborative project is the development of methods for automatic and accurate evaluation of fluorescence micrographs. As a part of this, we focus on the question of how to measure the accuracy of microscope image interpretation, by human experts or a computer system. Following standard practice we use methods motivated by receiver operator characteristics to discuss the accuracies of human experts and of neural network-based algorithms. For images of good quality the algorithms achieve the accuracy of the medium-skilled experts. In images with increased noise, the classifiers are outperformed by some of the experts. Furthermore, the neural network-based cell detection is much faster than the human experts.

Algorithms↗

PubMedDate not supplied

Fully automated biomedical image segmentation by self-organized model adaptation.

In this paper, we present a fully automated image segmentation method based on an algorithm that provides adaptive plasticity in function approximation problems: the deformable (feature) map (DM) algorithm. The DM approach reduces a class of similar function approximation problems to the explicit supervised one-shot training of a single data set. This is followed by a subsequent, appropriate similarity transformation, which is based on a self-organized deformation of the underlying multidimensional probability distributions. We apply this algorithm to the real-world problem of fully automated voxel-based multispectral image segmentation, employing magnetic resonance data sets of the human brain. In contrast to previous segmentation approaches, the knowledge obtained within the segmentation procedure of a single prototypical reference data set can be re-utilized for the segmentation of new, 'similar' data employing a strategy of incremental adaptive learning based on the DM algorithm. Thus, we obtain a fully automatic segmentation method that does neither require manual contour tracing of training regions, visual classification of voxel clusters, nor any other kind of human intervention. Our application demonstrates that flexible learning by a strategy of self-organized incremental model adaptation can contribute to increase the efficiency and practicability of biomedical image processing systems.

Algorithms↗

PubMedDate not supplied

Interactive image data labeling using self-organizing maps in an augmented reality scenario.

We present an approach for the convenient labeling of image patches gathered from an unrestricted environment. The system is employed for a mobile Augmented Reality (AR) gear: while the user walks around with the head-mounted AR-gear, context-free modules for focus-of-attention permanently sample the most 'interesting' image patches. After this acquisition phase, a Self-Organizing Map (SOM) is trained on the complete set of patches, using combinations of MPEG-7 features as a data representation. The SOM allows visualization of the sampled patches and an easy manual sorting into categories. With very little effort, the user can compose a training set for a classifier, thus, unknown objects can be made known to the system. We evaluate the system for COIL-imagery and demonstrate that a user can reach satisfying categorization within few steps, even for image data sampled from walking in an office environment. (An abbreviated version of some portions of this article appeared in [Bekel, H., Heidemann, G., & Ritter, H. (2005). SOM Based Image Data Structuring in an Augmented Reality Scenario. In Proceedings of the International Joint Conference on Neural Networks, Montreal, Canada.], as part of the IJCNN 2005 conference proceedings, published under the IEEE copyright).

Algorithms↗