Biomedical subjects

Helyett Aurengo

Publications and source records attributed to Helyett Aurengo.

3 recordsLinked to original sources

PubMed2005

[Does thyroid scintigram still have indications in 2005?].

Since 15 years, the indications of thyroid scintigrams have been dramatically reduced. This examination appeared useless in most cases of hypothyroidism and for the evaluation of thyroid cysts or for infracentimetric nodules. For greater solid nodules, its poor sensibility and bad specificity have resulted in its replacement by echography and fine needle biopsy. Thyroid scintigram is however usefull for the non obvious etiologic diagnosis of thyrotoxicosis and in case of thyroid goiter with a low TSH and normal thyroid hormons. Whole body131 I scans remain usefull for thyroid cancer follow up, especially after therapeutic dose of radioiodine.

Contraindications↗

PubMed2002

[Adaptation of thyroid function to excess iodine].

NORMALLY: The production of thyroid hormones is normally stable, despite iodine supplies that may vary widely and even on sudden excess iodine. The metabolism of iodine is characterised by adapted thyroid uptake, the requirements varying on the age and physiological status of the individual (pregnancy, breastfeeding) and by insufficient supplies in several areas in France. IN THE CASE OF EXCESS: The mechanisms that permit the thyroid to adapt to a sudden or chronic excess of iodine are immature in the newborn and sometimes deficient in adults, and may lead to iodine-induced dysthyroidism. Thanks to the recent progress made in thyroid physiology, these mechanisms are now better known. PATHOLOGICAL IMPACT: Iodine-induced hyperthyroidisms in a healthy or pathological thyroid are frequent. They are predominantly related to amiodarone. Iodine-related hypothyroidism frequently appears in cases of pre-existing thyroid diseases (asymptomatic autoimmune thyroiditis, for example). They are frequent in the newborn, notably in the premature. The iodine prophylaxis organised in Poland following the Tchernobyl accident led to very few pathological consequences in adults or children.

Adaptation, Physiological↗

PubMed2002

Selection of patients with solitary thyroid nodules for operation.

OBJECTIVE: To improve the preoperative selection for operation of patients with solitary thyroid nodules. DESIGN: Prospective cohort study. SETTING: University hospital, France. PATIENTS: 155 consecutive patients who presented with solitary thyroid nodules and were operated on. INTERVENTIONS: Clinical examination, ultrasound examination, fine needle aspiration biopsy, followed by total thyroid lobectomy with frozen section and final histological examination. MAIN OUTCOME MEASURE: Correct prediction of thyroid carcinoma or benign adenoma. RESULTS: A logistic regression analysis indicated that absence of rim (p < 0.002), solid and hypoechoic feature (p < 0.003) and malignant or suspicious fine needle aspiration biopsy results (p < 0.0001) were significantly associated with malignancy. Selection for operation by the logistic model would save 40 of 73 patients from operation and 40 of 59 from unnecessarily radical operation. It would detect a similar number of cancers as a strategy based solely on fine needle aspiration cytology. CONCLUSIONS: A combination of the available diagnostic methods provides substantial benefit in the preoperative selection of patients with an isolated thyroid nodule.

Adenocarcinoma, Papillary↗