Biomedical subjects

Henning Eickmeier

Publications and source records attributed to Henning Eickmeier.

23 records · Page 2Linked to original sources

PubMed2003

6-amino-3-bromo-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one-acetone-water (1/1/1): a fluorinated 2'-deoxyguanosine analogue with the sugar conformation of a ribonucleoside.

In the title compound, C(10)H(11)BrFN(5)O(4).C(3)H(6)O.H(2)O, the N-glycosylic bond torsion angle, chi, is anti [-108.0 (4) degrees ]. The sugar pucker is N-type [C2'-exo, (2)E with P = 346.5 (4) degrees and tau(m) = 34.5 (2) degrees ], and the conformation around the C-C bond linking the CH(2) group and the furan ring is -sc [torsion angle gamma = -70.0 (4) degrees ].

Carbohydrate Conformation↗

PubMed2003

5-Methyl-6-aza-2'-deoxyisocytidine.

In the title compound, 3-amino-2-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methyl-1,2,4-triazin-5(2H)-one, C(9)H(14)N(4)O(4), the conformation of the N-glycosidic bond is high-anti and the 2-deoxyribofuranosyl moiety adopts a North sugar pucker ((2)T(3)). The orientation of the exocyclic C-C bond between the -CH(2)OH group and the five-membered ring is ap (gauche, trans). The crystal packing is such that the nucleobases lie parallel to the ac plane; the planes are connected via hydrogen bonds involving the five-membered ring.

Crystallography, X-Ray↗

PubMed2002

The regioisomeric 1H(2H)-pyrazolo[3,4-d]pyrimidine N1- and N2-(2'-deoxy-beta-D-ribofuranosides).

In the title regioisomeric nucleosides, alternatively called 1-(2-deoxy-beta-D-erythro-furanosyl)-1H-pyrazolo[3,4-d]pyrimidine, C(10)H(12)N(4)O(3), (II), and 2-(2-deoxy-beta-D-erythro-furanosyl)-2H-pyrazolo[3,4-d]pyrimidine, C(10)H(12)N(4)O(3), (III), the conformations of the glycosylic bonds are anti [-100.4 (2) degrees for (II) and 15.0 (2) degrees for (III)]. Both nucleosides adopt an S-type sugar pucker, which is C2'-endo-C3'-exo ((2)T(3)) for (II) and 3'-exo (between (3)E and (4)T(3)) for (III).

Journal Article↗

PubMed2002

Tin-halide compounds. IV1. tert-butyltrichlorotin (IV).

The molecules of the title compound, [Sn(C(4)H(9))Cl(3)], adopt an eclipsed conformation with respect to the C and Cl atoms, and possess crystallographic C(s) symmetry. The molecular structure and geometric parameters are comparable with those of related organotin trihalides.

Journal Article↗

PubMed2002

The alpha-D anomer of 5-aza-7-deaza-2'-deoxyguanosine.

In the monohydrate of 2-amino-8-(2-deoxy-alpha-D-erythro-pentofuranosyl)-8H-imidazo[1,2-a][1,3,5]triazin-4-one, C(10)H(13)N(5)O(4) x H(2)O, denoted (I) or alpha Z(d), the conformation of the N-glycosylic bond is in the high-anti range [chi = 87.5 (3)]. The 2'-deoxyribofuranose moiety adopts a C2'-endo,C3'-exo((2')T(3')) sugar puckering (S-type sugar) and the conformation at the C4'-C5' bond is -sc (trans).

Aza Compounds↗