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Biomedical subjects

Henry Wang

Publications and source records attributed to Henry Wang.

5 recordsLinked to original sources
PubMed2004

Acute myocardial infarction in hemoglobin SC disease.

Although there are reports of myocardial infarction (MI) in patients with sickle cell diseases, an antemortem diagnosis of acute MI in a patient with compound heterozygous hemoglobin SC disease has not been reported. Herein, we present a patient with hemoglobin SC who suffered an acute MI. She had typical chest pain for myocardial ischemia, associated with ST elevations on the electrocardiogram (EKG) and elevations of cardiac injury markers diagnostic of infarction. The patient was treated with conventional therapies for acute coronary syndrome and also emergent red blood cell exchange. Interestingly, coronary angiography was completely normal in this patient. Potential mechanisms and management for acute MI in patients with sickle cell disease are discussed.

Adult↗
PubMed2004

Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells.

Using the "one-bead one-peptide" combinatorial technology, a library of random cyclic octapeptides and nonapeptides, consisting of natural and unnatural amino acids, was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment and proliferation of bronchioloalveolar carcinoma cells (H1650), employing a "cell growth on bead" assay. Consensus peptide sequences of cNleDXXXXc and cXNleDXXXXc (where Nle is norleucine) were identified. With alanine scanning and site-directed deletion, a typical ligand consisted of a motif of -NleDI/V/Nle- with two flanking cysteines. These peptide ligands were specific for promoting cell attachment of the H1650 cells and the cells of lymphoid cancers (Jurkat and Raji) but not other selected human cell lines of lung cancer and fibroblast. In an antibody blocking assay, integrin alpha(4)beta(1), which was overexpressed in H1650, Jurkat, and Raji, was identified as a putative receptor for these peptide ligands. Using Chinese hamster ovary cells transfected with either wild-type or mutant integrin alpha(4), a critical binding site for these peptides was localized to the glycine residue at position 190 of integrin alpha(4).

Alanine↗
PubMed1999

A Comparative Study of 511 keV SPECT and PET Using Separate 370 MBq F-18-FDG Doses on Different Days.

All previously reported comparative studies of 511 keV single-photon emission computed tomography (SPECT) and positron emission tomography (PET) have used one fluorine-18-fluorodeoxyglucose (FDG) dose, followed by PET and SPECT on the same day. This approach is inherently biased against the second imaging study. Therefore, we prospectively compared conventional PET and 511 keV SPECT in 23 patients with proven malignancy using separate 370 MBq FDG doses on different days employing an ECAT 951/31R PET scanner and a Trionix XLT-20 for SPECT. Discrepancies were evident in twelve of 23 patients (52%). In eight of these (66%) findings were seen exclusively on PET and represented the only metabolic evidence of disease. Thirty-seven of the 52 lesions (71%) detected at PET were also defined by SPECT, most above 2 cm. In 4 cases of extrahepatic abdominal disease (3 colorectal, 1 melanoma), both PET and SPECT missed small recurrent omental and perivesical lesions; several lesions up to 1.2 cm were also missed by CT and MRI.

Journal Article↗
PubMedDate not supplied

The effect of a voice assist manikin (VAM) system on CPR quality among prehospital providers.

UNLABELLED: Numerous studies have documented poor cardiopulmonary resuscitation (CPR) performance among prehospital providers during both simulated and actual resuscitations. Previous studies have shown that a real-time, voice assist manikin (VAM) system may improve CPR performance. OBJECTIVE: To determine whether VAM prompting would improve CPR performance by prehospital providers during simulated resuscitation. METHODS: In this prospective, randomized, crossover design, 114 prehospital providers performed two 3-minute sessions of one-rescuer CPR on a VAM-resuscitation manikin: one round with the VAM feature turned on and one with the feature turned off. The primary outcomes were measured at 15-second intervals and included the fraction of correct compressions, the mean compression depth, the fraction of correct ventilations, and the mean ventilation tidal volume. Generalized estimating equations were used to analyze the repeated measures. RESULTS: The VAM prompting was not directly associated with correct compressions during one-rescuer CPR in a cohort of subjects naïve to the system. However, the general decay in correct compressions seen over 3 minutes was attenuated with VAM prompting. Neither the compression depth nor the decay in compression depth over time was affected by VAM prompting. In contrast, VAM prompting did affect the fraction of correct ventilations and attenuated the time-dependent decline in correct ventilations in tidal volume. CONCLUSIONS: Use of VAM did not directly improve compression or ventilation rate or quality in this cohort of prehospital providers. However, use of VAM did prevent decay of compression and ventilation performance over time.

Adult↗