PubMed Health⌕ Search

Biomedical subjects

Henryk Chmielewski

Publications and source records attributed to Henryk Chmielewski.

6 recordsLinked to original sources
PubMed2006

[Central pontine myelinolysis--case report].

Central pontine myelinolysis (CPM) is a neurologic disorder, consists of demyelinisation without inflammation in the base of pons, with a relative sparing of the axons and the nerve cells. Clinical symptoms have various manifestations. They include pseudobalbular paralysis, tetraparesis, locked-in syndrome, coma. Rapid correction of persistence hyponatremia is a well recognized factor predisposing to CPM and nutritional deficiency is a commonly evoked cause of CMP as well. In more than half the cases it appeared in the late stages of chronic alcoholism. Among other medical conditions conjoined with CMP are liver failure and transplantation, electrolyte disturbances, cachexia from various causes, carcinoma, and severe bacterial infections. The autors report the cases of 31 year old patient with 4 year history of alkohol abuse in whom CPM developed with mild tetraparesis.

Adult↗
PubMed2006

[The dynamics of changes glucose concentration of patients with ischemic stoke in chosen times of day].

UNLABELLED: Cerebral ischemic stroke which basic exponent is an sudden occurrence of neurological deficits is also characterized by deep disturbances of human organism homeostasis. It is known that many functions of a healthy human organism is subjected to the rhythmical changes during the twenty-four hours, and the state of illness can disturb them in a crucial way. The aim of the study was to examine the dynamics of changes of glucose concentration in blood of patients with acute phase of cerebral ischemic stroke in chosen times of day. MATERIAL AND METHODS: The examinations were carried out on 16 non-diabetic patients (11 men, 5 women), aged between 57 and 76 where the cerebral ischemic stroke was confirmed by the Computer Tomography of the head. The patients were on high protein diet with total energy value of 2283 +/- 130.0 kcal per twenty-four hours in three meal times: at 09AM, 02PM, 06PM. The venous blood for examinations was drawn 6 times during the day: at 01AM, 05AM, 09AM, 01PM, 05PM, 09PM on the 1st, 3rd, 5th and 10th day after the stroke occurred. The following concentrations in blood were denoted glucose. RESULTS: In patients with the acute phase of cerebral ischemic stroke the significant disorders of carbohydrate metabolism can be observed in times between 09AM and 01PM on both the 1st, 3rd and the 5th day of the duration of the disease. CONCLUSIONS: The received results may take effect in the proofreading of pharmacological treatment with the consideration of the times of day.

Aged↗
PubMed2006

[Masked (atypical) depression in patients with back pain syndrome in outpatient neurological care].

UNLABELLED: Affective disorders, mainly depression is fast growing problem in highly civilised communities. The literature reports that 30-40% of patients seeking medical advice from specialists (not psychiatrists) in outpatient departments, suffer from these disorders. Many authors mention also diagnostic difficulties in dealing with atypical depression, and draw attention to the fact that this process is often "masked" by chronic pain. In neurological care we find a remarkable group of outpatients with back pain syndrome, mainly cervical and lumbar, with no corresponding lesions found on examination. This enabled us to assume that in some patients presenting with somatic symptoms and therefore referred to a neurologist, the reason of complaints can be depressive disorders. The aim of the study was to verify this hypothesis and to estimate the frequency of masked depression in neurological care. MATERIAL AND METHOD: 100 patients were examined in the neurological outpatient department, with the use of the two--Beck and Hamilton--scales of depression evaluation. RESULTS: A statistical analysis of the data thus obtained, showed that: back pain syndrome, as a symptom of depression, occurred in 14% of all patients referred to a neurologist, whereas in 37%--depressive disorders, not diagnosed before, were detected; in 88,2% they were of mild and moderate type. CONCLUSION: In some patients presenting with somatic symptoms and therefore referred to a neurologist, the reason of complaints are depresive disorders.

Adolescent↗
PubMed2005

[Statins and stroke].

The occurrence of stroke increases with age, particularly affecting the older elderly, a population also at higher risk for coronary heart disease (CHD). Epidemiological and observational studies have not shown a clear association between cholesterol levels and all causes of stroke. Nevertheless, large, long-term statin trials in patients with established CHD or et high risk for CHD (diabetes, hypertension) have shown that statins decrease stroke incidence in these populations even with a normal baseline cholesterol concentration. In patients with previous stroke statins reduce the incidence of coronary events, but whether they actually reduce the incidence of recurrent strokes in secondary prevention is unproved. In this review we discuss the potential reason for the effects of statins on stroke and the mechanisms of action. Statins probably reduce stroke by a variety of mechanisms. Several studies indicate that statins have multiple effects beyond lowering the cholesterol level. There is evidence that statins have neuroprotective properties for the acute ischaemic brain. Statins interfere with platelet aggregation and have anti-inflammatory and antioxidative properties. Also statins promote stabilisation of atherosclerotic plaques and improve blood flow to the ischaemic brain. The protective effects of statins might be due to their direct effect on endothelial cells leading to improved nitric oxide (NO) bioavailability. However further studies are needed to understand the full role of statins in the prevention of stroke in patients without established cardiovascular disease, representative of the typical stroke population.

Aged↗
PubMed2004

[Potential P300 in diagnostics of cognitive functions].

On the base of accessible literature and own experience general information concerning potential P300, the methodology of its research as well as the influence of different factors on each its components were reviewed. The possibilities of the clinical use of potential P300 in the diagnostics of cognitive disturbances were presented. It emerges that P300 potential can have practical use in the diagnostics of dementias, but because of its physiological and individual changeability it cannot be treated as a fully objective diagnostic method.

Aged↗