Biomedical subjects

Hervé Saint-Jalmes

Publications and source records attributed to Hervé Saint-Jalmes.

7 recordsLinked to original sources

PubMed2006

Small-animal MRI: signal-to-noise ratio comparison at 7 and 1.5 T with multiple-animal acquisition strategies.

OBJECTIVE: The purpose of this study was to compare the signal-to-noise ratio (SNR) of phantom and rat brain images performed at 1.5 T on a clinical MR system and at 7 T on a small-animal experimental system. Comparison was carried out by taking into account SNR values based on a single sample acquisition at 1.5 and 7 T as well as on simultaneous imaging of multiple samples at 1.5 T. METHODS: SNR was experimentally assessed on a phantom and rat brains at 1.5 and 7 T using 25 mm surface coils and compared to theoretical SNR gain estimations. The feasibility of multiple-animal imaging, using the hardware capabilities available on the 1.5 T system, was demonstrated. Finally, rat brain images obtained on a single animal at 7 T and on multiple animals acquired simultaneously at 1.5 T were compared. RESULTS: Experimentally determined SNR at 7 T was far below theoretical estimations. Taking into account chemical shift, susceptibility artifacts and modifications of T1 and T2 relaxation times at higher field, a 7-T system holds limited advantage over a 1.5-T system. Instead, a multiple-animal acquisition methodology was demonstrated on a clinical 1.5-T scanner. This acquisition method significantly increases imaging efficiency and competes with single animal acquisitions at higher field. CONCLUSION: Multiple-animal imaging using a standard clinical scanner has a great potential as a high-throughput acquisition method for small animals.

Animals↗

PubMed2004

Geometric depolarization in patterns formed by backscattered light.

We formulate a framework to extend the idea of Berry's topological phase to multiple light scattering, and in particular to backscattering of linearly polarized light. We show that the randomization of the geometric Berry's phases in the medium leads to a loss of the polarization degree of the light, i.e., to a depolarization. We use Monte Carlo simulations in which Berry's phase is calculated for each photon path. Then we average over the distribution of the geometric phases to calculate the form of the patterns, which we compare with experimental patterns formed by backscattered light between crossed or parallel polarizers.

Computer Simulation↗

PubMed2004

RF-induced temperature elevation along metallic wires in clinical magnetic resonance imaging: influence of diameter and length.

With the development of interventional MRI, heating of biological tissues along the metallic wires in the MRI scanner has become an important issue. To assess thermal response to RF exposure during MRI, we studied the temperature elevation near nonmagnetic metallic wires. All tests were performed on a 1.5 T clinical scanner. Four experiments were conducted to investigate the effects of the wire diameter, the excitation flip angle, the temperature distribution along the wire, and the wire length. Electromagnetic simulations of the experimental setup were made with the use of commercial method of moments (MoM) software and numerical simulations of Hallen's equations. Comparisons between measured and calculated values of the electric field are presented. This study demonstrates that 1) temperature decreases with the diameter of the wire,2) temperature increases quadratically with the excitation flip angle, 3) heating occurs not only at the tip but also along the wire, and 4) the heating peaks are not obtained for the classical resonant length multiple of lambda/4 (where lambda is the RF field wavelength). In addition, significant and rapid heating increases were observed in the close vicinity of the wire.

Computer Simulation↗

PubMed2004

In vitro rat colonic wall imaging with MR endoluminal coil: feasibility study and histologic correlations.

RATIONALE AND OBJECTIVES: Despite improvements, spatial resolution and image quality with routine surface coils are too limited when detailed information about the gastrointestinal layers is requested. The objective of our feasibility study was to evaluate the potential of a dedicated endoluminal coil to depict different layers of the colonic wall in an in vitro small animal model. MATERIALS AND METHODS: A single-loop coil (40 mm length, 5 mm width) was built using IC (printed circuit) technology. The coil was tuned to a frequency of 63.7 MHz and matched at 50 Omega for this frequency. The coil was housed in a biocompatible tube with an outer diameter of 18 F (6 mm). Ten segments of rat colon, surgically excised 5 hours earlier, were completely immersed in an isotonic solution. The coil was introduced through the lumen of colonic specimens. MRI experiments were performed on a 1.5 T MR Symphony system (Siemens, Erlangen, Germany) using imaging protocol combining high-resolution 2D Flash, fast imaging employing steady-state acquisition (TrueFISP), turbo spin echo (TSE), and 3D FastLow-Angle Shot (FLASH) sequences. After a 24-hour period of fixation in 10% formalin, colonic specimens were excised along the longitudinal axis for histologic analysis. RESULTS: The endoluminal coil provided high SNR allowing for the visualization of different layers of rat colonic walls. All the performed sequences made it possible to identify at least two different layers. On T1-weighted gradient-echo sequences, the mucosa was of high signal intensity, whereas the muscle layers had an intermediate to low signal intensity. The signal intensity of different wall layers was similar in different sequences. Histologic analysis identified three main layers. CONCLUSION: These results are well correlated with histologic findings and suggest that endoluminal MR imaging may have potential for accurate staging of colonic tumor or inflammatory process.

Animals↗

PubMed2003

Description and time reduction of a Monte Carlo code to simulate propagation of polarized light through scattering media.

Propagation of polarized light through a scattering medium has been studied with a Monte Carlo code to obtain polarized backscattered images. Studies of these backscattered patterns obtained with polarized illumination can be used as a technique to characterize the medium anisotropy factor g. First we present the different steps of the Monte Carlo simulation that describe polarized light propagation in a turbid medium. Monte Carlo is a good tool to simulate the backscattered polarized light but is time-consuming. Therefore, we consider two ways to decrease the computation time. The first way deals with angle sampling of the light direction. The second takes advantage of backscattered image symmetry to divide the simulation time by a factor of 4. By combining these two techniques we significantly decrease the code computation time.

Journal Article↗

PubMed2002

[NMR radiofrequency microcoil design: usefulness of electromagnetic simulation].

The extraction of the Nuclear Magnetic Resonance (NMR) spectra of samples having smaller and smaller volumes is a real challenge. Either these reductions of volume are dictated by the difficulties of production of sufficiently large samples or by necessities of miniaturisation of the analysing system, in both cases a careful design of the radiofrequency coil, ensuring an optimum reception of the NMR signal, is required. We have also evaluated the usefulness of electromagnetic simulation software for the design and optimisation of these radio-frequency coils, which are more and more used in biology and health research projects.

Electromagnetic Fields↗

PubMedDate not supplied

Scattering coefficient determination in turbid media with backscattered polarized light.

A simple empirical method is presented to determine the scattering coefficient mu' s from backscattered polarized images of turbid media. It uses the ratio, pixel by pixel, of two images that are the second and the first backscattered Stokes parameter images Q and I, respectively. Taking this image ratio, then integrating it over the azimuth angle, we get a function depending on the distance from the light entrance point. This function has a maximum. Using Monte Carlo simulations, for a fixed reduced scattering coefficient mu s and for an anisotropy factor g varying between 0 and 0.8, it is found a linear relationship between the scattering coefficient mu s and the inverse of the maximum position of this function.

Algorithms↗