Biomedical subjects

Hiroki Hasegawa

Publications and source records attributed to Hiroki Hasegawa.

3 recordsLinked to original sources

PubMed2026

Quality-of-life assessment in the randomized JBCRG-M06/EMERALD study of eribulin plus dual HER2 blockade in HER2-positive locally advanced or metastatic breast cancer.

BACKGROUND: Although taxanes are a mainstay treatment for locally advanced or metastatic breast cancer (LABC/MBC), they often impair quality of life (QoL). Treatments that avoid taxane-related QoL deteriorations would be valuable. METHODS: The JBCRG-M06/EMERALD trial (NCT03264547, UMIN000027938) compared eribulin with a taxane, each combined with trastuzumab and pertuzumab, in patients with human epidermal growth factor receptor type 2 (HER2)-positive LABC/MBC. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Module C30 (EORTC QLQ-C30) version 3.0. QoL deterioration was defined as a decrease in the Global Health Status (GHS) score by ≥ 10 points (minimum clinically important difference), disease progression, or death. RESULTS: QoL data were available for 210 (of 224 randomized) and 205 (of 222 randomized) patients in the eribulin and taxane groups, respectively. The median (95% confidence interval) time to QoL deterioration was 7.16 (6.28-8.34) months in the eribulin group versus 4.57 (4.17-6.14) months in the taxane group, with a hazard ratio of 0.80 (95% confidence interval 0.65-0.98; log-rank P = 0.08). QoL was maintained at 6 and 12 months in greater proportions of the eribulin group (62.7% and 30.5%) compared with the taxane group (43.5% and 25.5%). GHS scores remained stable over time in the eribulin group. GHS deteriorated between weeks 9 and 27 in the taxane group (i.e. during treatment) with subsequent recovery toward baseline. CONCLUSIONS: Eribulin could help avoid the early deteriorations in QoL that occur during taxane therapy and maintain QoL for longer in patents with HER2-positive LABC/MBC receiving trastuzumab and pertuzumab.

Adult↗

PubMed2004

[Psychological and physiological evaluations of music listening for mental stress].

UNLABELLED: Music elicits emotional and physiological responses in humans, providing excitement, mood elevation, relaxation, sedation and so on. Previous studies have been conducted on the effects of music, while little is known about the effects for the cognitive information processing. In this study we introduced various types of physiological indices, and explored the effects of music on participants' subjective and physiological responses to stress. First, eight participants (mean age; 25.6) were requested to perform a mental calculation task for 30 minutes. After that, they were exposed to music ("Bolero" by M. Ravel) for 13 minutes, while others were exposed to noise or just stayed in silence as controls. State-Trait Anxiety Inventory (STAI), salivary Immunoglobulin A (sigA), auditory event-related potentials (ERPs), heart rate (HR) and spectral analysis of heart rate variability (HRV) were assessed through the experiment. RESULTS: 1) After the calculation task: P300 amplitude of auditory ERPs significantly diminished (p = 0.027). Saliva secretion rate decreased (p = 0.028) and salivary IgA levels rose (p = 0.017) significantly. LF/HF ratio significantly increased (p = 0.042). 2) After music ("Bolero"): P300 amplitude significantly expanded (p = 0.048). State anxiety levels significantly lowered (p = 0.007). No significant physiological effect was found in those exposed to noise or silence. Our results of salivary IgA and LF/HF ratio suggest that the calculation task activates immune and sympathetic nervous system, while these systems are not affected by music. On the other hand, the result of P300 amplitude suggests that the central nervous system for the cognitive information processing is inactivated by the calculation task, and it can be recovered by music. The results of this study indicated that relaxing music is useful for the stress management, which invite further empirical investigation.

Adult↗

PubMed2003

The current role of preoperative and intraoperative autologous blood donation in pediatric open-heart surgery.

OBJECTIVE: We assessed the current role of preoperative and intraoperative autologous blood donation in pediatric open-heart surgery. METHODS: Group 1 consisted of 51 patients between 5 and 10 years old who underwent preoperative autologous blood donation. Group 2 consisted of 50 age-matched patients without preoperative donation as controls. Intraoperative donation was conducted in both groups prior to cardiopulmonary bypass. We evaluated perioperative blood cell count, blood loss, and the need for homologous blood products. RESULTS: No serious complications occurred in preoperative or intraoperative donation. Total preoperative donation storage was 17.5 +/- 3.4 mL/kg. Intraoperative donation was 21.7 +/- 6.1 mL/kg in Group 1 and 12.8 +/- 4.0 mL/kg in Group 2 (p < 0.001). On admission, serum hemoglobin was lower in Group 1 (12.2 +/- 1.0 g/dL versus 13.6 +/- 1.6 g/dL, p < 0.001) but returned postoperatively to the preoperative value. It hovered at a depressed level in Group 2 (12.2 +/- 1.4 versus 10.2 +/- 1.1 g/dL, p < 0.001). The homologous blood requirement was significantly less in Group 1 than in Group 2 (0% versus 10%, p < 0.05). Postoperative platelet counts showed similar curves, and blood loss was not statistically significantly different between groups. CONCLUSION: Preoperative and intraoperative donations are safe and continue to contribute uniquely to blood conservation, providing important options in comprehensive blood conservation programs in current pediatric open-heart surgery.

Blood Transfusion, Autologous↗