Unusual anterior radial head dislocation associated with transposed biceps tendon: a case report.
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Accidental Falls↗
Biomedical subjects
Hiromasa Miura
Publications and source records attributed to Hiromasa Miura.
Asymmetry of mediolateral laxity of the normal knee.
BACKGROUND: Understanding the normal kinematics of the joints is important for reconstructive surgery. However, only a few extensive studies have been done on medial and lateral laxity of the normal knee. METHODS: Radiographs of 50 normal knees were obtained under varus and valgus stress in both extension and flexion and the relative angle of the articular surface was measured. RESULTS: In extension, the mean angle was 4.9 degrees in varus stress and 2.4 degrees in valgus stress. In flexion, the mean angle was 4.8 degrees in varus stress and 1.7 degrees in valgus stress. Lateral laxity was significantly greater than medial laxity in both extension and flexion. CONCLUSIONS: Lateral laxity may be necessary for the medial pivot movement of the normal knee. There is some disagreement regarding the importance of pursuing the perfect rectangular gaps during total knee arthroplasty (TKA). The methods for measuring the tension of soft tissues during the operation are not accurate and do not always reflect the postoperative tensions of dynamic phases, such as walking and standing. Slight lateral laxity can be accepted with TKA, and further studies are necessary to determine whether prosthesis lift-off occurs in the replaced knee with slight lateral laxity similar to that in the normal knee.
Adult↗
Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty.
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Aged↗
Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty.
Anteroposterior stability was evaluated using a KT-2000 arthrometer in 18 patients (21 knees) continuously for up to 5 years after posterior cruciate ligament-retaining total knee arthroplasty. The Knee Society score, functional score, and the maximum flexion angle did not change significantly during the postoperative period. The mean anteroposterior displacement of all joints studied at both 30 degrees and 75 degrees of flexion did not change significantly during the 5-year period of observation, but 4 individual knees did exhibit increases in anteroposterior displacement of 3 mm or more. One of the 4 knees exhibited osteolysis beneath the tibial component. Three of these knees had undergone high tibial osteotomy at some time before the total knee arthroplasty.
Aged↗
Arthroscopic resection of the discoid lateral meniscus: long-term follow-up for 16 years.
PURPOSE: Although the clinical outcome of arthroscopic resection for a torn discoid lateral meniscus is known to be successful in the short term, long-term successful results are necessary. We reviewed the clinical results of arthroscopic meniscectomy for a torn discoid lateral meniscus in 29 knees, with an average follow-up of 16 years. METHODS: Subjective symptoms were evaluated with the use of a questionnaire developed by the International Knee Documentation Committee (IKDC). The trends of IKDC scores and patient age at the time of surgery were statistically evaluated through a stepwise piecewise linear regression analysis. Radiographic examination was performed in 15 knees. RESULTS: The average IKDC score was 87 points. Statistical analysis conducted with the use of a regression model of scores revealed that the regression line declined from 90 to 72 points at ages between 25 and 30 years at the time of surgery. Radiographic examination revealed that patients with degenerative changes at the lateral joint compartment, such as joint space narrowing and subchondral sclerosis, were of greater average age at the time of surgery than did patients who did not develop these changes. CONCLUSIONS: Results suggest that clinical outcomes associated with this method are successful for longer than 10 years for patients younger than 25 years of age; however, older patients may develop problems caused by degenerative changes that may result from increased stress on the affected joint compartment. LEVEL OF EVIDENCE: Level IV, therapeutic case series.
Adolescent↗
The effect of ankle rotation on cutting of the tibia in total knee arthroplasty.
BACKGROUND: Extramedullary alignment guides are commonly used to prepare the tibia during total knee arthroplasty. One disadvantage is that the guide is easily affected by the position of the ankle joint. The tibia may have a rotational mismatch between its proximal and distal ends. We hypothesized that a rotational mismatch might cause incorrect positioning of an extramedullary alignment guide and evaluated such a mismatch on the predicted postoperative coronal alignment of the tibia. METHODS: Fifty-three osteoarthritic knees with varus deformity in fifty-one patients were evaluated with use of computerized tomography scans before total knee arthroplasty. We defined one anteroposterior axis of the ankle joint and five different anteroposterior axes of the proximal aspect of the tibia using three-dimensional bone models from the computerized tomography data. We measured the rotational angle between the anteroposterior axis of the ankle joint and the proximal part of the tibia. The distal end of the extramedullary guide was placed in front of the center of the ankle joint (on the line of the extended anteroposterior axis of the ankle joint), and the proximal end was placed on the line of the extended anteroposterior axis of the proximal part of the tibia. We established spatial coordinates to evaluate the effect of the rotational angle on the predicted postoperative coronal alignment of the tibia and calculated the presumed tibial coronal alignment. RESULTS: The rotational angle was positive (3.6 degrees to 19.7 degrees) for all of the anteroposterior axes of the proximal aspect of the tibia, indicating that the ankle joint was externally rotated relative to the proximal part of the tibia. The predicted tibial coronal alignment was varus (0.5 degrees to 5.1 degrees) for all of the anteroposterior axes of the proximal part of the tibia. CONCLUSIONS: When an extramedullary alignment guide is used to prepare the tibia in total knee arthroplasty, varus alignment of the tibial component can occur because of a rotational mismatch between the proximal part of the tibia and the ankle joint.
Aged↗
Factors associated with functional limitation in stair climbing in female Japanese patients with knee osteoarthritis.
BACKGROUND: Osteoarthritis (OA) of the knee is a common form of arthritis, and affects quality of life. We investigated factors associated with functional limitation in stair climbing among female Japanese patients with knee OA. As weight is a known risk factor for knee OA, we focused on body weight at 40 years of age, and examined the association with present weight, past weight, and weight change. METHODS: Subjects were 360 Japanese women aged 40-92 years who were newly diagnosed with knee OA at 3 university hospitals over a 1-year period. Factors associated with the severity of functional limitation in stair climbing were assessed by calculating odds ratios (OR) using the proportional odds model in logistic regression. RESULTS: Weight at diagnosis showed a positive association with severe functional limitation in stair climbing; however, a negative association was observed for weight change since age 40. Further analysis indicated that the association with weight at age 40 (highest vs. lowest quartile, OR=2.84, 95% confidence interval: 1.03-7.83, trend p=0.071) is stronger than weight at diagnosis. Other significant characteristics were age (70+ vs. 40-59 years, OR=7.37), previous knee pain and/or swelling 12 years or more before diagnosis (OR=2.67), and physical work (OR=1.94). In addition, higher parity was found to be a negatively associated factor (for tripara or more, OR=0.41). CONCLUSIONS: This study identified factors, such as heavy weight at age 40 and physical labor, which are potentially useful for preventing severe functional limitation for female knee OA patients. In addition, higher parity was associated with milder stair climbing limitation.
Adult↗
Repetitive tensile stress to rat caudal vertebrae inducing cartilage formation in the spinal ligaments: a possible role of mechanical stress in the development of ossification of the spinal ligaments.
OBJECT: Mechanical stress has been considered one of the important factors in ossification of the spinal ligaments. According to previous clinical and in vitro studies, the accumulation of tensile stress to these ligaments may be responsible for ligament ossification. To elucidate the relationship between such mechanical stress and the development of ossification of the spinal ligaments, the authors established an animal experimental model in which the in vivo response of the spinal ligaments to direct repetitive tensile loading could be observed. METHODS: The caudal vertebrae of adult Wistar rats were studied. After creating a novel stimulating apparatus, cyclic tensile force was loaded to rat caudal spinal ligaments at 10 N in 600 to 1800 cycles per day for up to 2 weeks. The morphological responses were then evaluated histologically and immunohistochemically. After the loadings, ectopic cartilaginous formations surrounded by proliferating round cells were observed near the insertion of the spinal ligaments. Several areas of the cartilaginous tissue were accompanied by woven bone. Bone morphogenetic protein-2 expression was clearly observed in the cytoplasm of the proliferating round cells. The histological features of the rat spinal ligaments induced by the tensile loadings resembled those of spinal ligament ossification observed in humans. CONCLUSIONS: The findings obtained in the present study strongly suggest that repetitive tensile stress to the spinal ligaments is one of the important causes of ligament ossification in the spine.
Animals↗
The extramedullary guide of the proximal tibia resection should be seen straight in front during total knee arthroplasty.
If surgeons see the shaft of the extramedullary guide from lateral to the guide during preparation of the proximal tibia resection during total knee arthroplasty, the tibial component may be implanted in varus position in the frontal plane. In order to clarify the effect of the angle of the surgeons' sight relative to the sagittal plane and the posterior slope angle of the resected surface on varus position of the tibial component in the frontal plane, mathematical analysis was performed. Three-dimensional coordinate system was utilized so that the central axis of the tibial shaft on the Z-axis and the shaft of the guide were skew. The relationship between two lines was analyzed solving equations on three dimensional planes. When the posterior slope angle is 10 degrees, and if surgeons see the shaft of the guide 10 degrees, 20 degrees and 30 degrees lateral to the sagittal plane, and the shaft and the central axis of the tibial shaft would seem to be parallel, the true varus tilt angle of the shaft on the frontal plane is 1.8 degrees, 3.7 degrees and 5.8 degrees, respectively. The extramedullary guide should be seen straight in front of the guide.
Arthroplasty, Replacement, Knee↗
Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients.
Using three-dimensional computed tomography in 50 osteoarthritic knees, we simulated at various cutting angles the tibial cut for total knee arthroplasty. Cutting angles of 0 degrees, 3 degrees, 5 degrees, 7 degrees, 9 degrees, and 11 degrees were used. We then calculated the anterior and posterior thicknesses, the medial-lateral widths, and the medial and lateral condylar depths of the resected tibial bone at each cutting angle. Each set of measurements was evaluated according to a comparison between the cutting angle and the anatomic posterior slopes. The cutting angles showing the smallest anterior-posterior difference at the medial and lateral plateaus were 9 degrees and 7 degrees, respectively. The mean anatomic posterior slopes at the medial and lateral plateaus were 9.0 degrees and 8.1 degrees, respectively. When the tibia was cut at the cutting angle closest to the medial anatomical posterior slope in each knee, the thickness of the lateral posterior plateaus resected from 12 knees (24%) was more than 10 mm. Among these 12 knees, the cutting angle was more than 9 degrees in 9 knees (75%). In contrast, when the tibia was cut at the cutting angle closest to the lateral anatomical posterior slope, only one resected medial posterior plateau was more than 10 mm. The cutting angle of this case was 7 degrees. Therefore, in consideration of the thickness of bone resection from anatomic posterior slope, we demonstrated the importance of using the lateral anatomic posterior tibial slope as a guide to the tibial cut. There was no significant difference with respect to resected bone morphology at any cutting angle.
Aged↗
The prognostic and therapeutic relevance of p27kip1 in Ewing's family tumors.
PURPOSE: Ewing's family tumors (EFTs) display the characteristic fusion gene EWS-Fli1. We have reported EWS-Fli1 may promote the cell cycle progression accompanied by the suppression of the expression of cyclin-dependent kinase inhibitor p27(kip1) in EFT cells. Here, we describe the prognostic and therapeutic relevance of p27 in EFTs. EXPERIMENTAL DESIGN: We examined tumor samples taken from 21 patients with primary EFTs for the expression of p27 protein immunohistochemically and evaluated its correlation with clinical outcome. We also investigated the usefulness of p27 as a therapeutic strategy in vitro and in vivo using p27 expression adenovirus. Finally, we examined the process of EWS-Fli1-mediated reduction of p27 expression. RESULTS: Immunohistochemical analysis showed that a low expression level of p27 protein was related to poor event-free survival in an univariate analysis and that the expression level of p27 correlated more significantly with patient survival than several clinical factors in a multivariate survival analysis. Overexpression of p27 with the adenoviral vector remarkably inhibited the cell growth in all EFT cells tested and further induced apoptosis in the wild-type p53 EFT cells. In vivo studies demonstrated a reduction in tumor growth of EFT xenograft in nude mice treated with the intratumoral injection of p27-expressing adenovirus. EWS-Fli1 did not significantly affect the p27 promoter activity and p27 mRNA levels. However, the challenge of the proteasome inhibitor caused accumulation of p27 protein in EFT cells. These data strongly suggest EWS-Fli1 might attenuate p27 protein level via activation of the proteasome-mediated degradation pathway. CONCLUSIONS: Our findings provide the first evidence of the prognostic relevance of p27 expression in EFTs. We propose p27 as a novel and powerful therapeutic factor for the molecular target therapy of EFTs.
Adenoviridae↗
Simple screening method for deep vein thrombosis by duplex ultrasonography using patients' active maximum ankle dorsiflexion.
We hypothesized that venous obstruction by deep vein thrombosis (DVT) only slightly augments venous outflow from lower limbs by active ankle movements. If our hypothesis is true, we thought that we could develop a new screening method for DVT using duplex ultrasonography. Subjects were 22 lower limbs of 11 patients who gave informed consent for venography after total hip or knee arthroplasty. Around postoperative 19.0 days (range 15-32 days), we measured the ratios, called flow ratios, of the peak flow signal with active maximum ankle dorsiflexion and that at rest using duplex ultrasonography in the bilateral femoral veins. On the same day, we then performed bilateral venography. Thrombosis was detected in 5 of the 22 lower limbs. The mean flow ratios with and without DVT were 1.18 (range 1.0-1.3) and 3.31 (range 1.8-4.8), respectively. The flow ratios with DVT were significantly lower than those without DVT. Pain or difficulty performing active maximum ankle dorsiflexion was not observed in any of the operated or unoperated lower limbs during the ultrasound examination. In conclusion, ultrasonographic measurement of flow ratios may become a simple screening method for DVT in lower limbs without the pain or difficulty of performing active maximum ankle dorsiflexion.
Aged↗
Anatomical analysis of the femoral condyle in normal and osteoarthritic knees.
It is important to understand anatomical feature of the distal femoral condyle for treatment of osteoarthritic knees. Detailed measurement of the femoral condyle geometry, however, has not been available in osteoarthritic knees including valgus deformity. This study evaluated femoral condyle geometry in 30 normal knees, 30 osteoarthritic knees with varus deformity, and 30 osteoarthritic knees with valgus deformity using radiographs and magnetic resonance imaging (MRI). In radiographic analysis in the coronal plane, the femoral joint angle (lateral angle between the femoral anatomic axis and a tangent to femoral condyles) was 83.3 degrees in the normal knees, 83.8 degrees in the varus knees, and 80.7 degrees in the valgus knees. In MRI analysis in the axial plane, the posterior condylar tangent showed 6.4 degrees of internal rotation relative to the transepicondylar axis in the normal knees, 6.1 degrees in the varus knees, and 11.5 degrees in the valgus knees. These results suggested that there was no hypoplasia of the medial condyle in the varus knees, but the lateral condyle in the valgus knees was severely distorted. Surgeons should take this deformity of the lateral femoral condyle into account when total knee arthroplasty is performed for a valgus knee.
Aged↗
The oblique posterior femoral condylar radiographic view following total knee arthroplasty.
BACKGROUND: It is often difficult to evaluate the posterior aspects of the femoral condyles after total knee arthroplasty. We have developed an imaging technique involving the use of the oblique posterior condylar view for the evaluation of the posterior aspects of the femoral condyles. The purpose of the present study was to compare the efficacy of this view with that of the true-lateral view. METHODS: Three orthopaedic surgeons analyzed fifty-five sets of radiographs (consisting of oblique posterior condylar and true-lateral views) for patients who had undergone total knee arthroplasty. The accuracy and reproducibility of the oblique posterior condylar view for the detection of radiolucencies were compared with those of the true-lateral view. RESULTS: The oblique posterior condylar view was significantly better than the true-lateral view for the detection of radiolucencies of the posterior aspects of the femoral condyles (p < 0.0005). CONCLUSIONS: Radiographic analysis with use of the oblique posterior condylar view is technically easy and is accurate for the evaluation of radiolucencies of the posterior aspects of the femoral condyles after total knee arthroplasty.
Aged↗
[Bone quantity and quality to its mechanical integrity].
Bone strength is made up of quantity (mass, mineralization), geometry (anatomy, micro architecture, collagen structure), and turnover/damage accumulation. While most of the mechanical behavior can be explained by measures of porosity, several additional descriptors of the geometry have been proposed for better predictions of fracture risk. This review introduces various aspects of these relationships between bone quantity and quality to its mechanical integrity.
Biomechanical Phenomena↗
Mechanical effects of the intraarticular administration of high molecular weight hyaluronic acid plus phospholipid on synovial joint lubrication and prevention of articular cartilage degeneration in experimental osteoarthritis.
OBJECTIVE: To examine in vivo the effects of a mixture of high molecular weight hyaluronic acid (HA) plus phospholipids on joint lubrication and articular cartilage degeneration. METHODS: Experimental osteoarthritis (OA) of the right knee was induced by anterior cruciate and medial collateral ligament transection in 40 rabbits. The animals were subjected to 8 consecutive weekly intraarticular administrations of high molecular weight HA (the HA200 group), conventional molecular weight HA (the HA80 group), or high molecular weight HA plus L-delta dipalmitoyl phosphatidylcholine liposomes (the PHA group) and were killed 1 week after the final injection. The remaining transected right knees (the OA group) and randomly selected nontransected contralateral left knees (the control group) were collected simultaneously. Each group (n = 10) was divided into 2 equal subgroups, one of which was evaluated histologically while the other was subjected to a lubricating ability test using a pendulum friction tester. RESULTS: The injected knees had a tendency to demonstrate less damage to the articular cartilage compared with the OA group, and the histologic findings in all groups except for the PHA group differed significantly from the control group. There was a significant difference in the mean +/- SD friction coefficient between the control group (0.0100 +/- 0.00300) and the OA (0.0206 +/- 0.00649), HA200 (0.0190 +/- 0.00427), and HA80 (0.0177 +/- 0.00712) groups (P < 0.05 for each comparison), but not between the control group and the PHA group (0.0150 +/- 0.00330) (P = 0.15). CONCLUSION: To our knowledge, this is the first in vivo study to examine whether intraarticular injections of phospholipids influence joint lubrication by acting as a boundary lubricant, thus protecting articular cartilage from degenerative changes.
Animals↗
Changes in anteroposterior stability following total knee arthroplasty.
This study evaluated the changes in anteroposterior stability at flexion and extension following posterior cruciate ligament (PCL)-retaining and PCL-substituting total knee arthroplasty (TKA), in comparison with normal knees. Altogether, 29 knees of 24 patients underwent either PCL-retaining ( n = 19) or PCL-substituting ( n = 10) TKA. Anteroposterior displacement was measured with a KT-2000 arthrometer preoperatively, 1 month after surgery, and again an average of 3 years after surgery. Anteroposterior stability at flexion and extension did not change following PCL-retaining TKA and was not significantly different from that of normal subjects, whereas anteroposterior stability increased following PCL-substituting TKA and was significantly greater than that of normal subjects an average of 3 years after surgery.
Adult↗
Tibial shaft axis does not always serve as a correct coronal landmark in total knee arthroplasty for varus knees.
Predicted postoperative knee alignment was calculated when total knee arthroplasty was performed after 1 of 3 different methods of tibia preparation in 30 osteoarthritic knees with varus deformity. In Method 1, the tibia was cut perpendicular to the tibial shaft. In Method 2, the tibia was cut perpendicular to a line connecting the center of the tibial plateau and the center of the talar dome. In method 3, tibial resection was determined with an original template so that tibial resection would be perpendicular to a line connecting the center of the resected tibial plateau and the center of the talar dome. Methods 1 and 2 caused significantly more valgus alignment than Method 3 (P<.0001). The postoperative weight-bearing ratio was in Method 1, 57.7%, in Method 2, 53.6% and 50.0% in Method 3. These results suggest that cutting the tibia perpendicular to the tibial shaft can cause valgus alignment in total knee arthroplasty for varus knees.
Analysis of Variance↗