A ring-finger protein CIP-2 is a novel regulator of COUP-TF action in the adrenal cortex.
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Adrenal Cortex↗
Biomedical subjects
Hirotaka Shibata
Publications and source records attributed to Hirotaka Shibata.
Trends in pharmacologic management of hypertension in Japan one year after the publication of the JSH 2000 guidelines. First Japanese Society of Hypertension.
Hypertension, a major risk factor for cerebrovascular disease and heart disease, often requires drug therapy. The First Japanese Society of Hypertension Guidelines for the Management of Hypertension were published in June 2000. In the present work, we surveyed 447 doctors who attended continuing medical education meetings between March and July 2001 to elucidate national antihypertensive treatment patterns. A minimum level of 150/95 mmHg was selected by 60% and 140/90 mmHg by 19% of respondents as thresholds for initiating drug treatment, while 130/85 mmHg was selected by 26% of respondents as the goal blood pressure in middle-aged uncomplicated male patients. Sixty-nine percent of respondents selected a calcium antagonist as their previous drug of the first choice and 22% selected an ACE inhibitor. For their future first choice, 55% would prescribe an angiotensin II receptor antagonist (AIIA); 19% an ACE inhibitor; and 16% a calcium antagonist. Seventy-two percent selected a calcium antagonist + an ACE inhibitor and 17% selected a calcium antagonist + AIIA as their previous first-choice drug combinations. For their future drug combinations, 56% would select an AIIA + a calcium antagonist and 25% a calcium antagonist + an ACE inhibitor. Four weeks or less was selected by 69% of respondents as the period intended to reach the goal blood pressure. Eight weeks or more was selected by 28%. Overall, our data suggest that doctors in Japan are still cautious and conservative in controlling blood pressure levels but want rapid achievement of the goal blood pressure. Their first choice drug is shifting from calcium antagonists to AIIAs. These findings indicate the need for continued effort to evaluate the diversity of clinical practice and assess the appropriateness of continuing medical education.
Antihypertensive Agents↗
[Nuclear receptors in the pathophysiology of endocrine tumors].
Nuclear orphan receptors COUP-TF and DAX-1 negatively regulate the transcriptional activity of SF-1, a steroidogenic cell-specific activator of various steroidogenic cytochrome P-450 genes. Expression of COUP-TF and DAX-1 are greatly decreased in cortisol-producing adrenocortical adenomas, while CYP17 is overexpressed. In contrast, DAX-1 expression is increased and SF-1 expression is decreased in deoxycorticosterone-producing adrenocortical adenomas, where CYP17 expression is low. These data suggest that DAX-1 and/or COUP-TF may repress CYP17 expression in adrenocortical tumors. In addition, SF-1 is expressed in the human pituitary gonadotroph and pituitary adenomas of gonadotrophic origin. SF-1 expression is associated with the in vitro secretion of LH in pituitary adenomas. Opposing effects of SF-1 and DAX-1 and/or COUP-TF may regulate the differential responses of various SF-1 target genes in different endocrine tumors.
Adenoma↗