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Biomedical subjects

Hirotsugu Takabatake

Publications and source records attributed to Hirotsugu Takabatake.

5 recordsLinked to original sources

Solitary capillary hemangioma of the lung: report of 2 resected cases detected by high-resolution CT.

We report 2 cases of capillary hemangioma, each presenting as a solitary nodule in the peripheral lung. Both of the patients were asymptomatic with a small solitary nodule that had revealed by computed tomography. In both cases, the nodule was resected surgically under a clinical diagnosis of early lung cancer. Macroscopically, each lesion was ill defined and irregular in shape with a dark brown cut surface. Microscopically, the alveolar septa in both nodules were thickened by accumulations of numerous thin-walled capillary vessels, which characteristically extended along, or infiltrated, each septum. We diagnosed these lesions as "solitary capillary hemangioma" of the peripheral lung. Tumors or tumorlike lesions of capillary vessels in the lung are rare. Among them, pulmonary capillary hemangiomatosis (PCH) has been described as multiple nodules in the lung parenchyma or bronchovascular walls, comprised of infiltrating thin-walled capillary blood vessels. Moreover, PCH-like foci have been found in a retrospective study of autopsy cases. However, the presented cases should be differentiated from PCH in terms of their clinical setting such as history of hypertension or veno-occlusive disease and multiplicity of the lesion. This is a rare case series of solitary capillary hemangioma discovered incidentally during life, and the lesions were difficult to differentiate radiologically from early lung cancer. After the recent advances in imaging diagnosis for early detection of peripheral lung cancer, these lesions are important to bear in mind for differential diagnosis of bronchioloalveolar carcinoma.

Diagnosis, Differential↗

A method for bronchoscope tracking by combining a position sensor and image registration.

This paper describes a method for tracking a bronchoscope by combining a position sensor and image registration. A bronchoscopy guidance system is a tool for providing real-time navigation information acquired from pre-operative CT images to a physician during a bronchoscopic examination. In this system, one of the fundamental functions is tracking a bronchoscope's camera motion. Recently, a very small electromagnetic position sensor has become available. It is possible to insert this sensor into a bronchoscope's working channel to obtain the bronchoscope's camera motion. However, the accuracy of its output is inadequate for bronchoscope tracking. The proposed combination of the sensor and image registration between real and virtual bronchoscopic images derived from CT images is quite useful for improving tracking accuracy. Furthermore, this combination has enabled us to achieve a real-time bronchoscope guidance system. We performed evaluation experiments for the proposed method using a rubber phantom model. The experimental results showed that the proposed system allowed the bronchoscope's camera motion to be tracked at 2.5 frames per second.

Artificial Intelligence↗

Automated nomenclature of bronchial branches extracted from CT images and its application to biopsy path planning in virtual bronchoscopy.

We propose a novel anatomical labeling algorithm for bronchial branches extracted from CT images. This method utilizes multiple branching models for anatomical labeling. In the actual labeling process, the method selects the best candidate models at each branching point. Also a special labeling procedure is proposed for the right upper lobe. As an application of the automated nomenclature of bronchial branches, we utilized anatomical labeling results for assisting biopsy planning. When a user inputs a target point around suspicious regions on the display of a virtual bronchoscopy (VB) system, the path to the desired position is displayed as a sequence of anatomical names of branches. We applied the proposed method to 25 cases of CT images. The labeling accuracy was about 90%. Also the paths to desired positions were generated by using anatomical names in VB.

Algorithms↗

Hybrid bronchoscope tracking using a magnetic tracking sensor and image registration.

In this paper, we propose a hybrid method for tracking a bronchoscope that uses a combination of magnetic sensor tracking and image registration. The position of a magnetic sensor placed in the working channel of the bronchoscope is provided by a magnetic tracking system. Because of respiratory motion, the magnetic sensor provides only the approximate position and orientation of the bronchoscope in the coordinate system of a CT image acquired before the examination. The sensor position and orientation is used as the starting point for an intensity-based registration between real bronchoscopic video images and virtual bronchoscopic images generated from the CT image. The output transformation of the image registration process is the position and orientation of the bronchoscope in the CT image. We tested the proposed method using a bronchial phantom model. Virtual breathing motion was generated to simulate respiratory motion. The proposed hybrid method successfully tracked the bronchoscope at a rate of approximately 1 Hz.

Algorithms↗

Phase I study of carboplatin, irinotecan and docetaxel on a divided schedule with recombinant human granulocyte colony stimulating factor support in patients with stage IIIB or IV non-small cell lung cancer.

A phase I study was conducted to determine dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of carboplatin combined with irinotecan and docetaxel on a divided schedule with recombinant human granulocyte colony stimulating factor (rhG-CSF) support in patients with stage IIIB or IV non-small cell lung cancer. Carboplatin was given at the dose of AUC5 on day 1. Irinotecan and docetaxel on days 1 and 8 were administered at a starting dose of 40 and 30 mg/m2 as level 1. Subsequent levels were: irinotecan/docetaxel (in mg/m2), 50/30 (level 2), 60/30 (level 3) and 60/35 (level 4). rhG-CSF was given at 50 mg/m2 on days 5-15. Cycles were repeated every 3 weeks. Between May 1999 and April 2001, 31 patients were registered in this phase I study. Level 4 was judged as the MTD. The DLTs were considered diarrhea and febrile neutropenia. The overall response rate was 32.3% and median survival was 490 days with 1-year survival of 65.1%. We conclude that both irinotecan 60 mg/m2 and docetaxel 30 mg/m2 on days 1 and 8 in combination with an AUC5 of carboplatin on day 1 with rhG-CSF support is recommended for phase II study. The response rate and survival data in this phase I study are encouraging. We considered that the pathogenesis of diarrhea involved not only direct cytotoxic damage to the mucosa, but also bacterial overgrowth.

Adenocarcinoma↗